Singh S, Parikh T, Sandhu HK, Shah NH, Malick AW, Singhal D, Serajuddin ATM. Supersolubilization and amorphization of a model basic drug, haloperidol, by interaction with weak acids. Pharm Res. 2013;30:1561–73.
Article CAS PubMed Google Scholar
Heo MY, Piao ZZ, Kim TW, Cao QR, Kim A, Lee BJ. Effect of solubilizing and microemulsifying excipients in polyethylene glycol 6000 solid dispersion on enhanced dissolution and bioavailability of ketoconazole. Arch Pharm Res. 2005;28:604–11.
Article CAS PubMed Google Scholar
Badawy SIF, Gray DB, Zhao F, Sun D, Schuster AE, Hussain MA. Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389. Pharm Res. 2006;23:989–96.
Article CAS PubMed Google Scholar
Bassi P, Kaur G. pH modulation: a mechanism to obtain pH-independent drug release. Expert Opin Drug Deliv. 2010;7:845–573.
Article CAS PubMed Google Scholar
Box K, Comer JE, Gravestock T, Stuart M. New ideas about the solubility of drugs. Chem Biodivers. 2009;6:1767–88.
Article CAS PubMed Google Scholar
Maghsoodi M, Nokhodchi A, Azhdarzadeh Oskuei M, Heidari S. Formulation of cinnarizine for stabilization of its physiologically generated supersaturation. AAPS PharmSciTech. 2019;20:1–11.
Shelton MJ, Adams JM, Hewitt RG, et al. Effects of spontaneous gastric hypoacidity on the pharmacokinetics of zidovudine and didanosine. Pharmacotherapy. 1997;17:438–44.
Lahner E, Annibale B, Delle FG. Systematic review: Helicobacter pylori infection and impaired drug absorption. Aliment Pharmacol Ther. 2009;29:379–86.
Article CAS PubMed Google Scholar
Russell TL, Berardi RR, Barnett JL, et al. pH-related changes in the absorption of dipyridamole in the elderly. Pharm Res. 1994;11:136–43.
Article CAS PubMed Google Scholar
Champagne ET. Low gastric hydrochloric acid secretion and mineral bioavailability. Adv Exp Med Biol. 1989;249:173–84.
Article CAS PubMed Google Scholar
Hamed R, Awadallah A, Sunoqrot S, Tarawneh O, Nazzal S, AlBaraghthi T, Sayyad J Al, Abbas A. pH-dependent solubility and dissolution behavior of carvedilol—case example of a weakly basic BCS class II drug. AAPS PharmSciTech. 2016;17:418–426.
Kataoka M, Fukahori M, Ikemura A, Kubota A, Higashino H, Sakuma S, Yamashita S. Effects of gastric pH on oral drug absorption: in vitro assessment using a dissolution/permeation system reflecting the gastric dissolution process. Eur J Pharm Biopharm. 2016;101:103–11.
Article CAS PubMed Google Scholar
Rubbens J, Brouwers J, Tack J, Augustijns P. Gastrointestinal dissolution, supersaturation and precipitation of the weak base indinavir in healthy volunteers. Eur J Pharm Biopharm. 2016;109:122–9.
Article CAS PubMed Google Scholar
Choi JS, Kwon SH, Lee SE, Jang WS, Byeon JC, Jeong HM, Park JS. Use of acidifier and solubilizer in tadalafil solid dispersion to enhance the in vitro dissolution and oral bioavailability in rats. Int J Pharm. 2017;526:77–87.
Article CAS PubMed Google Scholar
Shim JB, Lee JK, Jo H, Hwang JH, Jeong SM, Jo JI, Lee D, Yuk SH, Khang G. Effect of acidifier on the dissolution property of a solid dispersion of raloxifene HCl. Macromol Res. 2013;21:42–8.
Siepe S, Herrmann W, Borchert HH, Lueckel B, Kramer A, Ries A, Gurny R. Microenvironmental pH and microviscosity inside pH-controlled matrix tablets: An EPR imaging study. J Control Release. 2006;112:72–8.
Article CAS PubMed Google Scholar
Badawy SI, Hussain MA. Microenvironmental pH modulation in solid dosage forms. J Pharm Sci. 2007;96:948–59.
Article CAS PubMed Google Scholar
Maghsoodi M, Mollaie Astemal S, Nokhodchi A, Kiaie H, Baradar Khoshfetrat A, Talebi F. An insight into Eudragit S100 preserving mechanism of cinnarizine supersaturation. AAPS PharmSciTech. 2022;23:1–16.
Xie T, Taylor LS. Dissolution performance of high drug loading celecoxib amorphous solid dispersions formulated with polymer combinations. Pharm Res. 2016;33:739–50.
Article CAS PubMed Google Scholar
Xu L, Luo Y, Feng J, Xu M, Tao X, He H, Tang X. Preparation and in vitro-in vivo evaluation of none gastric resident dipyridamole (DIP) sustained-release pellets with enhanced bioavailability. Int J Pharm. 2012;422:9–16.
Article CAS PubMed Google Scholar
Khan KA. The concept of dissolution efficiency. J Pharm Pharmacol. 1975;27:48Y49.
Baghel S, Cathcart H, Redington W, O’Reilly NJ. An investigation into the crystallization tendency/kinetics of amorphous active pharmaceutical ingredients: a case study with dipyridamole and cinnarizine. Eur J Pharm Biopharm. 2016;104:59–71.
Article CAS PubMed Google Scholar
Kiew TY, Cheow WS, Hadinoto K. Preserving the supersaturation generation capability of amorphous drug-polysaccharide nanoparticle complex after freeze drying. Int J Pharm. 2015;484:115–23.
Article CAS PubMed Google Scholar
Yani Y, Chow PS, Tan RBH. Molecular simulation study of the effect of various additives on salbutamol sulfate crystal habit. Mol Pharm. 2011;8:1910–8.
Article CAS PubMed Google Scholar
Xie S, Poornachary SK, Chow PS, Tan RBH. Direct precipitation of micronsize salbutamol sulfate: new insights into the action of surfactants and polymeric additives. Cryst Growth Des. 2010;10:3363–71.
Tran PHL, Tran HTT, Lee BJ. Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release. J Control Release. 2008;129:59–65.
Article CAS PubMed Google Scholar
Lin-Vien D, Colthup NB, Fateley WG, Grasselli JG. The handbook of infrared and Raman characteristic frequencies of organic molecules: Elsevier. 1991.
Chen S, Zhu J, Ma F, Fang Q, Li Y. Preparation and characterization of solid dispersions of dipyridamole with a carrier “Copolyvidonum Plasdone® S-630. Drug Dev Ind Pharm. 2007;33:888–99.
Article CAS PubMed Google Scholar
Parmar VK, Shah SA. Hydrochloride salt co-crystals: preparation, characterization and physicochemical studies. Pharm Dev Technol. 2013;18:443–53.
Article CAS PubMed Google Scholar
Yoo S-U, Krill SL, Wang Z, Telang C. Miscibility/stability considerations in binary solid dispersion systems composed of functional excipients towards the design of multi-component amorphous systems. J Pharm Sci. 2009;98:4711–23.
Zhou R, Moench P, Heran C, Lu X, Mathias N, Faria TN, Wall DA, Hussain MA, Smith RL, Sun D. pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model. Pharm Res. 2005;22:188–92.
Article CAS PubMed Google Scholar
Diakidou A, Vertzoni M, Dressman J, Reppas C. Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates. Biopharm Drug Dispos. 2009;30:318–25.
Article CAS PubMed Google Scholar
Onoue S, Inoue R, Taniguchi C, Kawabata Y, Yamashita K, Wada K, Yamauchi Y, Yamada S. Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. Int J Pharm. 2012;426:61–6.
Article CAS PubMed Google Scholar
Avdeef A. Solubility of sparingly-soluble ionizable drugs. Adv Drug Deliv Rev. 2007;59:568–90.
Article CAS PubMed Google Scholar
Taniguchi C, Inoue R, Kawabata Y, Yamashita K. Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. Int J Pharm. 2012;434:148–54.
Article CAS PubMed Google Scholar
Schilling SU, Bruce CD, Shah NH, Malick AW, McGinity JW. Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets. Int J Pharm. 2008;361:158–68.
Article CAS PubMed Google Scholar
Espinoza R, Hong E, Villafuerte L. Influence of admixed citric acid on the release profile of pelanserin hydrochloride from HPMC matrix tablets. Int J Pharm. 2000;201:165–73.
Article CAS PubMed Google Scholar
Siepe S, Lueckel B, Krammer A, Ries A, Gurny Robert. Strategies for the design of hydrophilic matrix tablets with controlled microenvironmental pH. Int J Pharm. 2006;316:14–20.
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