Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials

Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem. 1986;261:6084–9.

Article  CAS  PubMed  Google Scholar 

Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K. Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J Alzheimer’s Dis. 2013;33:S123–139.

Article  Google Scholar 

Iqbal K, Grundke-Iqbal I, Zaidi T, Merz PA, Wen GY, Shaikh SS, et al. Defective brain microtubule assembly in Alzheimer’s disease. Lancet. 1986;2:421–6.

Article  CAS  PubMed  Google Scholar 

Iqbal K, Grundke-Iqbal I, Smith AJ, George L, Tung YC, Zaidi T. Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc Natl Acad Sci USA. 1989;86:5646–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee VM, Balin BJ, Otvos L Jr, Trojanowski JQ. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science. 1991;251:675–8.

Article  CAS  PubMed  Google Scholar 

Novak M, Kabat J, Wischik CM. Molecular characterization of the minimal protease resistant tau unit of the Alzheimer’s disease paired helical filament. EMBO J. 1993;12:365–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA. 1986;83:4913–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012;71:362–81.

Article  PubMed  Google Scholar 

Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82:239–59.

Article  CAS  PubMed  Google Scholar 

Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B. Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathol. 1987;74:209–25.

Article  CAS  PubMed  Google Scholar 

Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology. 1992;42:631–9.

Article  CAS  PubMed  Google Scholar 

Elahi FM, Miller BL. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017;13:457–76.

Article  PubMed  PubMed Central  Google Scholar 

Therriault J, Zimmer ER, Benedet AL, Pascoal TA, Gauthier S, Rosa-Neto P. Staging of Alzheimer’s disease: past, present, and future perspectives. Trends Mol Med. 2022;28:726–741.

Article  CAS  PubMed  Google Scholar 

Ossenkoppele R, Hansson O. Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer’s disease. Alzheimers Dement. 2021;17:1998–2008.

Article  PubMed  Google Scholar 

Wolters EE, Ossenkoppele R, Verfaillie SCJ, Coomans EM, Timmers T, Visser D, et al. Regional [(18)F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2020;47:2866–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

La Joie R, Bejanin A, Fagan AM, Ayakta N, Baker SL, Bourakova V, et al. Associations between [(18)F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample. Neurology. 2018;90:e282–e290.

Article  PubMed  PubMed Central  Google Scholar 

Cho H, Choi JY, Hwang MS, Kim YJ, Lee HM, Lee HS, et al. In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum. Ann Neurol. 2016;80:247–58.

Article  CAS  PubMed  Google Scholar 

Scholl M, Lockhart SN, Schonhaut DR, O’Neil JP, Janabi M, Ossenkoppele R, et al. PET Imaging of Tau Deposition in the Aging Human Brain. Neuron. 2016;89:971–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiang L, Sun X, Austin TO, Muralidharan H, Jean DC, Liu M, et al. Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains. Curr Biol. 2018;28:2181–2189.e2184.

Article  CAS  PubMed  Google Scholar 

Dehmelt L, Halpain S. The MAP2/Tau family of microtubule-associated proteins. Genome Biol. 2005;6:204.

Article  PubMed  Google Scholar 

Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, et al. Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis. J Neurosci. 2016;36:1001–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamdane M, Bretteville A, Sambo AV, Schindowski K, Begard S, Delacourte A, et al. p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death. J Cell Sci. 2005;118:1291–8.

Article  CAS  PubMed  Google Scholar 

Qu MH, Li H, Tian R, Nie CL, Liu Y, Han BS, et al. Neuronal tau induces DNA conformational changes observed by atomic force microscopy. Neuroreport. 2004;15:2723–7.

CAS  PubMed  Google Scholar 

Qi H, Cantrelle FX, Benhelli-Mokrani H, Smet-Nocca C, Buee L, Lippens G, et al. Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation. Biochemistry. 2015;54:1525–33.

Article  CAS  PubMed  Google Scholar 

Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nat Neurosci. 2014;17:357–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camero S, Benitez MJ, Barrantes A, Ayuso JM, Cuadros R, Avila J, et al. Tau protein provides DNA with thermodynamic and structural features which are similar to those found in histone-DNA complex. J Alzheimer’s Dis. 2014;39:649–60.

Article  CAS  Google Scholar 

Brandt R. The tau proteins in neuronal growth and development. Front Biosci. 1996;1:d118–130.

Article  CAS  PubMed  Google Scholar 

DeVos SL, Hyman BT. Tau at the Crossroads between Neurotoxicity and Neuroprotection. Neuron. 2017;94:703–4.

Article  CAS  PubMed  Google Scholar 

Pevalova M, Filipcik P, Novak M, Avila J, Iqbal K. Post-translational modifications of tau protein. Bratisl Lek Listy. 2006;107:346–53.

CAS  PubMed  Google Scholar 

Gorantla NV, Chinnathambi S. Tau Protein Squired by Molecular Chaperones During Alzheimer’s Disease. J Mol Neurosci. 2018;66:356–68.

Article  CAS  PubMed  Google Scholar 

Jiang S, Bhaskar K. Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy. Front Mol Neurosci. 2020;13:586731.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmadi S, Zhu S, Sharma R, Wilson DJ, Kraatz HB. Interaction of metal ions with tau protein. The case for a metal-mediated tau aggregation. J Inorg Biochem. 2019;194:44–51.

Article  CAS  PubMed  Google Scholar 

Chiti F, Dobson CM. Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade. Annu Rev Biochem. 2017;86:27–68.

Article  CAS  PubMed  Google Scholar 

Mamun AA, Uddin MS, Mathew B, Ashraf GM. Toxic tau: structural origins of tau aggregation in Alzheimer’s disease. Neural Regen Res. 2020;15:1417–20.

Article  PubMed  PubMed Central  Google Scholar 

Iqbal K, Liu F, Gong CX. Tau and neurodegenerative disease: the story so far. Nat Rev Neurol. 2016;12:15–27.

Article  CAS  PubMed  Google Scholar 

Iqbal K, Liu F, Gong CX. Recent developments with tau-based drug discovery. Expert Opin Drug Disco. 2018;13:399–410.

Article  CAS  Google Scholar 

Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron. 1989;3:519–26.

Article  CAS  PubMed 

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