Document Type : Original Research Article

Authors

Department of Chemistry/ college of science, University of Babylon, Babylon, Iraq

Abstract

Chitosan is a product of the deacetylation of chitin and widely found in the nature. So the modification of chitosan has been an important aspect of chitosan research. Chitosan have a good solubility, pH-sensitive target also increasing number of delivery systems. The study was synthesis rization of some chitosan- amoxicillin H1 and chitosan-diclofenac H2 prodrug and study release of drug. Structure of H1 and H2 were nalyzed by FT-IR, H-NMR and character TGA. Drug release of prodrug polymers was be measured in three different pH (pH=2, 7, and 8) at 37 ℃. From the obtained results these polymers appear good drug release in a basic medium for an ester bond of polymers as compared with amide bond of the other polymer.

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