The bacterial non-2-ulosonic acids, including pseudaminic acid, legionaminic acid, acinetaminic acid, fusaminic acid and several epimers, have been identified from the pathogenic Gram-negative bacteria. The intriguing structures and less-understood biological functions make them attractive synthetic targets. In this review, the chemical syntheses of four types of non-2-ulosonic acid structures reported in the past two decades are summarized, together with some recent progresses on the application of the synthetic non-2-ulosonic acid derivatives.

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