Research ArticleHematologyInflammation Open Access | 10.1172/JCI163968

Santhosh Kumar Pasupuleti,1 Baskar Ramdas,1 Sarah S. Burns,1 Lakshmi Reddy Palam,1 Rahul Kanumuri,1 Ramesh Kumar,1 Taruni Reddy Pandhiri,1 Utpal P. Dave,2 Nanda Kumar Yellapu,3 Xinyu Zhou,4 Chi Zhang,4 George E. Sandusky,5 Zhi Yu,6,7 Michael C. Honigberg,6 Alexander G. Bick,8 Gabriel K. Griffin,9,10 Abhishek Niroula,7 Benjamin L. Ebert,11 Sophie Paczesny,12 Pradeep Natarajan,6,7,13 and Reuben Kapur1,14

1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

Find articles by Bick, A. in: JCI | PubMed | Google Scholar |

1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

Find articles by Niroula, A. in: JCI | PubMed | Google Scholar |

1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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1Herman B Wells Center for Pediatric Research, Department of Pediatrics and

2Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

3Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.

4Department of Medical and Molecular Genetics and

5Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

6Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

7Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

8Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

9Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

10Epigenomics Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

11Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA.

12Department of Microbiology and Immunology, Medical University of South Carolina, Charlestown, South Carolina, USA.

13Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

14Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Address correspondence to: Sophie Paczesny, Medical University of South Carolina, Department of Microbiology and Immunology, 173 Ashley Avenue, MSC 504, Room BSB 203, South Carolina 29425, USA. Email: paczesns@musc.edu. Or to: Reuben Kapur, Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, Indiana 46202, USA. Phone: 317.274.4658; Email: rkapur@iu.edu.

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