Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach

Loomba, R., Friedman, S. L. & Shulman, G. I. Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell 184, 2537–2564 (2021).

Article  CAS  PubMed  Google Scholar 

Huang, D. Q., El-Serag, H. B. & Loomba, R. Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol. 18, 223–238 (2021).

Article  PubMed  Google Scholar 

Albhaisi, S., Chowdhury, A. & Sanyal, A. J. Non-alcoholic fatty liver disease in lean individuals. JHEP Rep. 1, 329–341 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Eslam, M. et al. MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease. Gastroenterology 158, 1999–2014.e1 (2020).

Article  CAS  PubMed  Google Scholar 

Lazarus, J. V. et al. Advancing the global public health agenda for NAFLD: a consensus statement. Nat. Rev. Gastroenterol. Hepatol. 19, 60–78 (2022).

Article  CAS  PubMed  Google Scholar 

Younossi, Z. M. et al. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology 77, 1335–1347 (2023).

Article  PubMed  Google Scholar 

Riazi, K. et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. Lancet Gastroenterol. Hepatol. 7, 851–861 (2022).

Article  PubMed  Google Scholar 

Tamargo, J. A. et al. Food insecurity is associated with magnetic resonance-determined nonalcoholic fatty liver and liver fibrosis in low-income, middle-aged adults with and without HIV. Am. J. Clin. Nutr. 113, 593–601 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Heimbach, J. Debate: A bridge too far – liver transplantation for nonalcoholic steatohepatitis will overwhelm the organ supply. Liver Transplant. 20, S32–S37 (2014).

Article  Google Scholar 

Shaker, M., Tabbaa, A., Albeldawi, M. & Alkhouri, N. Liver transplantation for nonalcoholic fatty liver disease: new challenges and new opportunities. World J. Gastroenterol. 20, 5320–5330 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maher, T. M. & Strek, M. E. Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat. Respir. Res. 20, 205 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Singh, S. et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin. Gastroenterol. Hepatol. 13, 643–654.e9 (2015).

Article  PubMed  Google Scholar 

Roskilly, A. et al. Fibrosis progression rate in a systematic review of placebo-treated nonalcoholic steatohepatitis. Liver Int. 41, 982–995 (2021).

Article  PubMed  Google Scholar 

Kleiner, D. E. et al. Association of histologic disease activity with progression of nonalcoholic fatty liver disease. JAMA Netw. Open 2, e1912565 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Angulo, P. et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 149, 389–397.e10 (2015).

Article  PubMed  Google Scholar 

Sanyal, A. J. et al. Prospective study of outcomes in adults with nonalcoholic fatty liver disease. N. Engl. J. Med. 385, 1559–1569 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vilar-Gomez, E. et al. Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study. Gastroenterology 155, 443–457.e17 (2018).

Article  PubMed  Google Scholar 

Ajmera, V. et al. A prospective study on the prevalence of NAFLD, advanced fibrosis, cirrhosis and hepatocellular carcinoma in people with type 2 diabetes. J. Hepatol. https://doi.org/10.1016/J.JHEP.2022.11.010 (2022).

Article  PubMed  Google Scholar 

Yan, Z. et al. Liver fibrosis scores and prognosis in patients with cardiovascular diseases: a systematic review and meta-analysis. Eur. J. Clin. Invest. 52, e13855 (2022).

Article  CAS  PubMed  Google Scholar 

Ostovaneh, M. R. et al. Association of liver fibrosis with cardiovascular diseases in the general population: the Multi-Ethnic Study of Atherosclerosis (MESA). Circ. Cardiovasc. Imaging 11, e007241 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Huang, D. Q. et al. Shared mechanisms between cardiovascular disease and NAFLD. Semin. Liver Dis. 42, 455–464 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Chhatwal, J. et al. Analysis of a simulation model to estimate long-term outcomes in patients with nonalcoholic fatty liver disease. JAMA Netw. Open 5, E2230426 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Sanyal, A. J. et al. Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis. Hepatology 75, 1235–1246 (2022).

Article  CAS  PubMed  Google Scholar 

Promrat, K. et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 51, 121–129 (2010).

Article  CAS  PubMed  Google Scholar 

Vilar-Gomez, E. et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology 149, 367–378.e5 (2015).

Article  PubMed  Google Scholar 

Zelber-Sagi, S., Salomone, F. & Mlynarsky, L. The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease: evidence and plausible mechanisms. Liver Int. 37, 936–949 (2017).

Article  CAS  PubMed  Google Scholar 

Dinu, M., Pagliai, G., Casini, A. & Sofi, F. Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials. Eur. J. Clin. Nutr. 72, 30–43 (2018).

Article  CAS  PubMed  Google Scholar 

Booth, F. W., Roberts, C. K. & Laye, M. J. Lack of exercise is a major cause of chronic diseases. Compr. Physiol. 2, 1143–1211 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Bianchi, A. et al. Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis. J. Immunol. 206, 904–916 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, D., Konyn, P., Cholankeril, G. & Ahmed, A. Physical activity is associated with nonalcoholic fatty liver disease and significant fibrosis measured by FibroScan. Clin. Gastroenterol. Hepatol. 20, e1438–e1455 (2022).

Article  CAS  PubMed  Google Scholar 

Sherry, A. et al. Physical activity is inversely associated with hepatic fibro-inflammation: a population-based cohort study using UK Biobank data. JHEP Rep. 5, 100622 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Berzigotti, A. et al. Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: the SportDiet study. Hepatology 65, 1293–1305 (2017).

Article  PubMed  Google Scholar 

Lassailly, G. et al. Bariatric surgery provides long-term resolution of nonalcoholic steatohepatitis and regression of fibrosis. Gastroenterology 159, 1290–1301.e5 (2020).

Article  PubMed  Google Scholar 

Aminian, A. et al. Association of bariatric surgery with major adverse liver and cardiovascular outcomes in patients with biopsy-proven nonalcoholic steatohepatitis. J. Am. Med. Assoc. 326, 2031–2042 (2021).

Article  Google Scholar 

Rustgi, V. K. et al. Bariatric surgery reduces cancer risk in adults with nonalcoholic fatty liver disease and severe obesity. Gastroenterology 161, 171–184.e10 (2021).

Article  CAS  PubMed  Google Scholar 

Alvarado-Tapias, E. et al. Bariatric surgery is associated with alcohol-related liver disease and psychiatric disorders associated with AUD. Obes. Surg. 33, 1494–1505 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Barrichello, S. et al. The effect of the intra-gastric balloon on gastric emptying and the DeMeester score. Obes. Surg. 30, 38–45 (2020).

Article  PubMed  Google Scholar 

Bazerbachi, F. et al. Intragastric balloon placement induces significant metabolic and histologic improvement in patients with nonalcoholic steatohepatitis. Clin. Gastroenterol. Hepatol. 19, 146–154.e4 (2021).

Article  CAS  PubMed  Google Scholar 

Kaur, S. et al. In vitro models for the study of liver biology and diseases: advances and limitations. Cell Mol. Gastroenterol. Hepatol. 15, 559–571 (2023).

Article  CAS 

留言 (0)

沒有登入
gif