Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study

Cho HJ, Morey V, Kang JY, Kim KW, Kim TK. Prevalence and risk factors of spine, shoulder, hand, hip, and knee osteoarthritis in community-dwelling koreans older than age 65 years. Clin Orthop Relat Res. 2015;473(10):3307–14.

Article  PubMed  PubMed Central  Google Scholar 

Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T. Global estimates of the need for rehabilitation based on the global burden of disease study 2019: a systematic analysis for the global burden of disease study 2019. Lancet. 2021;396(10267):2006–17.

Article  PubMed  Google Scholar 

Sacitharan PK. Ageing and osteoarthritis. Subcell Biochem. 2019;91:123–59.

Article  CAS  PubMed  Google Scholar 

Gandhi R, Woo KM, Zywiel MG, Rampersaud YR. Metabolic syndrome increases the prevalence of spine osteoarthritis. Orthop Surg. 2014;6(1):23–7.

Article  PubMed  PubMed Central  Google Scholar 

Kluzek S, Newton JL, Arden NK. Is osteoarthritis a metabolic disorder? Br Med Bull. 2015;115(1):111–21.

Article  CAS  PubMed  Google Scholar 

Godziuk K, Prado CM, Woodhouse LJ, Forhan M. Prevalence of sarcopenic obesity in adults with end-stage knee osteoarthritis. Osteoarthr Cartil. 2019;27(12):1735–45.

Article  CAS  Google Scholar 

Kendzerska T, King LK, Lipscombe L, Croxford R, Stanaitis I, Hawker GA. The impact of hip and knee osteoarthritis on the subsequent risk of incident diabetes: a population-based cohort study. Diabetologia. 2018;61(11):2290–9.

Article  PubMed  Google Scholar 

Liang X, Chou OHI, Cheung CL, Cheung BMY. Is hypertension associated with arthritis? The United States national health and nutrition examination survey 1999–2018. Ann Med. 2022;54(1):1767–75.

Article  PubMed  PubMed Central  Google Scholar 

Southan J, McHugh E, Walker H, Ismail HM. Metabolic signature of articular cartilage following mechanical injury: an integrated transcriptomics and metabolomics analysis. Front Mol Biosci. 2020;7: 592905.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tootsi K, Vilba K, Martson A, Kals J, Paapstel K, Zilmer M. Metabolomic signature of amino acids biogenic amines and lipids in blood serum of patients with severe osteoarthritis. Metabolites. 2020;10(8):323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertusa C, Mifsut D, Morales JM, Tarin JJ, Cano A, Monleon D, Garcia-Perez MA. Metabolomic analysis of seere osteoarthritis in a Spanish population of women compared to healthy and osteoporotic subjects. Metabolites. 2022;12(8):677.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Werdyani S, Liu M, Zhang H, Sun G, Furey A, Randell EW, Rahman P, Zhai G. Endotypes of primary osteoarthritis identified by plasma metabolomics analysis. Rheumatology. 2021;60(6):2735–44.

Article  CAS  PubMed  Google Scholar 

Kettunen J, Demirkan A, Wurtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikainen LP, Pirinen M, et al. Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun. 2016;7:11122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, et al. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014;46(6):543–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012;40:D109-114.

Article  CAS  PubMed  Google Scholar 

Boer CG, Hatzikotoulas K, Southam L, Stefansdottir L, Zhang Y, Coutinho de Almeida R, Wu TT, Zheng J, Hartley A, Teder-Laving M, et al. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell. 2021;184(24):6003–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chong J, Xia J. 2104. Using MetaboAnalyst 4 0 for Metabolomics Data Analysis, Interpretation and Integration with Other Omics Data. Methods Mol Biol. 11 337–360.

Burgess S, Small DS, Thompson SG. A review of instrumental variable estimators for mendelian randomization. Stat Methods Med Res. 2017;26(5):2333–55.

Article  PubMed  Google Scholar 

Zhai G. Alteration of metabolic pathways in osteoarthritis. Metabolites. 2019;9(1):11.

Article  PubMed  PubMed Central  Google Scholar 

Showiheen SAA, Sun AR, Wu X, Crawford R, Xiao Y, Wellard RM, Prasadam I. Application of metabolomics to osteoarthritis: from basic science to the clinical approach. Curr Rheumatol Rep. 2019;21(6):26.

Article  PubMed  Google Scholar 

Li JT, Zeng N, Yan ZP, Liao T, Ni GX. A review of applications of metabolomics in osteoarthritis. Clin Rheumatol. 2021;40(7):2569–79.

Article  PubMed  Google Scholar 

Maher AD, Coles C, White J, Bateman JF, Fuller ES, Burkhardt D, Little CB, Cake M, Read R, McDonagh MB, et al. 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. J Proteome Res. 2012;11(8):4261–8.

Article  CAS  PubMed  Google Scholar 

Costello CA, Hu T, Liu M, Zhang W, Furey A, Fan Z, Rahman P, Randell EW, Zhai G. Metabolomics signature for non-responders to total joint replacement surgery in primary osteoarthritis patients: the newfoundland osteoarthritis study. J Orthop Res. 2020;38(4):793–802.

Article  CAS  PubMed  Google Scholar 

Hou Y, Yin Y, Wu G. Dietary essentiality of “nutritionally non-essential amino acids” for animals and humans. Exp Biol Med. 2015;240(8):997–1007.

Article  CAS  Google Scholar 

Li Y, Xiao W, Luo W, Zeng C, Deng Z, Ren W, Wu G, Lei G. Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health. Amino Acids. 2016;48(4):907–14.

Article  CAS  PubMed  Google Scholar 

Morris SM Jr. Arginine metabolism: boundaries of our knowledge. J Nutr. 2007;137(6 Suppl 2):1602S-1609S.

Article  CAS  PubMed  Google Scholar 

Marti ILAA, Reith W. Arginine-dependent immune responses. Cell Mol Life Sci. 2021;78(13):5303–24.

Article  Google Scholar 

Zhai G. Clinical relevance of biochemical and metabolic changes in osteoarthritis. Adv Clin Chem. 2021;101:95–120.

Article  CAS  PubMed  Google Scholar 

Zhang W, Sun G, Likhodii S, Liu M, Aref-Eshghi E, Harper PE, Martin G, Furey A, Green R, Randell E, et al. Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients. Osteoarthrs Cart. 2016;24(5):827–34.

Article  CAS  Google Scholar 

Choi WS, Yang JI, Kim W, Kim HE, Kim SK, Won Y, Son YO, Chun CH, Chun JS. Critical role for arginase II in osteoarthritis pathogenesis. Ann Rheum Dis. 2019;78(3):421–8.

Article  CAS  PubMed  Google Scholar 

Li J, Zhang Z, Huang X. l-Arginine and allopurinol supplementation attenuates inflammatory mediators in human osteoblasts-osteoarthritis cells. Int J Biol Macromol. 2018;118(Pt A):716–21.

Article  CAS  PubMed  Google Scholar 

Del’Arco AE, Argolo DS, Guillemin G, Costa MFD, Costa SL, Pinheiro AM. Neurological infection, kynurenine pathway, and parasitic infection by neospora caninum. Front Immunol. 2021;12: 714248.

Article  CAS  PubMed  Google Scholar 

Eryavuz Onmaz D, Sivrikaya A, Isik K, Abusoglu S, Albayrak Gezer I, Humeyra Yerlikaya F, Abusoglu G, Unlu A, Tezcan D. Altered kynurenine pathway metabolism in patients with ankylosing spondylitis. Int Immunopharmacol. 2021;99: 108018.

Article  CAS  PubMed  Google Scholar 

Meier TB, Savitz J. The kynurenine pathway in traumatic brain injury: implications for psychiatric outcomes. Biol Psychiatry. 2022;91(5):449–58.

Article  PubMed  Google Scholar 

Modoux M, Rolhion N, Mani S, Sokol H. Tryptophan metabolism as a pharmacological target. Trends Pharmacol Sci. 2021;42(1):60–73.

Article  CAS  PubMed  Google Scholar 

Igari T, Obara K, Ono S, Toba Y. Tryptophan metabolism in the joint diseases. Acta Vitaminol Enzymol. 1975;29(1–6):194–7.

CAS  PubMed  Google Scholar 

Logters TT, Laryea MD, Jager M, Schadel-Hopfner M, Windolf J, Flohe S, Altrichter J, Scholz M, Paunel-Gorgulu AN. Kynurenine inhibits chondrocyte proliferation and is increased in synovial fluid of patients with septic arthritis. J Orthop Res. 2010;28(11):1490–6.

Article  PubMed  Google Scholar 

Wang X, Zhao Y, Li S, Wang Y, Jia C, Yang X, Li S, Zhang B, Wei W, Chang Y

留言 (0)

沒有登入
gif