A Reduction in Antenatal Steroid Dose Was Associated with Reduced Cardiac Dysfunction in a Sheep Model of Pregnancy

Jobe AH, Goldenberg RL. Antenatal corticosteroids: an assessment of anticipated benefits and potential risks. Am J Obstet Gynecol. 2018;219:62–74. https://doi.org/10.1016/j.ajog.2018.04.007.

Article  CAS  PubMed  Google Scholar 

Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2017;3:CD004454. https://doi.org/10.1002/14651858.CD004454.pub3.

Article  PubMed  Google Scholar 

Dempsey EM. What should we do about low blood pressure in preterm infants. Neonatology. 2017;111:402–7. https://doi.org/10.1159/000460603.

Article  PubMed  Google Scholar 

Ikegami M, Jobe AH, Newnham J, Polk DH, Willet KE, Sly P. Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med. 1997;156:178–84. https://doi.org/10.1164/ajrccm.156.1.9612036.

Article  CAS  PubMed  Google Scholar 

Asztalos EV, Murphy KE, Willan AR, Matthews SG, Ohlsson A, Saigal S, et al. Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (macs-5). JAMA Pediatr. 2013;167:1102–10. https://doi.org/10.1001/jamapediatrics.2013.2764.

Article  PubMed  Google Scholar 

Stutchfield PR, Whitaker R, Gliddon AE, Hobson L, Kotecha S, Doull IJ. Behavioural, educational and respiratory outcomes of antenatal betamethasone for term caesarean section (astecs trial). Arch Dis Child Fetal Neonatal Ed. 2013;98:F195-200. https://doi.org/10.1136/archdischild-2012-303157.

Article  PubMed  Google Scholar 

Alexander N, Rosenlöcher F, Dettenborn L, Stalder T, Linke J, Distler W, et al. Impact of antenatal glucocorticoid therapy and risk of preterm delivery on intelligence in term-born children. J Clin Endocrinol Metab. 2016;101:581–9. https://doi.org/10.1210/jc.2015-2453.

Article  CAS  PubMed  Google Scholar 

Savoy C, Ferro MA, Schmidt LA, Saigal S, Van Lieshout RJ. Prenatal betamethasone exposure and psychopathology risk in extremely low birth weight survivors in the third and fourth decades of life. Psychoneuroendocrinology. 2016;74:278–85. https://doi.org/10.1016/j.psyneuen.2016.09.021.

Article  CAS  PubMed  Google Scholar 

Räikkönen K, Gissler M, Kajantie E. Associations between maternal antenatal corticosteroid treatment and mental and behavioral disorders in children. Jama. 2020;323:1924–33. https://doi.org/10.1001/jama.2020.3937.

Article  CAS  PubMed  Google Scholar 

Alexander N, Rosenlocher F, Stalder T, Linke J, Distler W, Morgner J, et al. Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children. J Clin Endocrinol Metab. 2012;97:3538–44. https://doi.org/10.1210/jc.2012-1970.

Article  CAS  PubMed  Google Scholar 

Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, et al. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. The Lancet. 2005;365:1856–62. https://doi.org/10.1016/s0140-6736(05)66617-2.

Article  CAS  Google Scholar 

Constantinof A, Moisiadis VG, Kostaki A, Szyf M, Matthews SG. Antenatal glucocorticoid exposure results in sex-specific and transgenerational changes in prefrontal cortex gene transcription that relate to behavioural outcomes. Sci Rep. 2019;9:764. https://doi.org/10.1038/s41598-018-37088-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61–73. https://doi.org/10.1056/NEJMra0708473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eberle C, Fasig T, Brüseke F, Stichling S. Impact of maternal prenatal stress by glucocorticoids on metabolic and cardiovascular outcomes in their offspring: a systematic scoping review. PLoS One. 2021;16:e0245386. https://doi.org/10.1371/journal.pone.0245386.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barker DJ, Bagby SP, Hanson MA. Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nat Clin Pract Nephrol. 2006;2:700–7. https://doi.org/10.1038/ncpneph0344.

Article  PubMed  Google Scholar 

Kumagai Y, Kemp MW, Yaegashi N, Saito M. Contemporary challenges and developments: antenatal corticosteroid therapy. Curr Obstet Gynecol Rep. 2019;8:115–22. https://doi.org/10.1007/s13669-019-00270-z.

Article  Google Scholar 

Kemp MW, Saito M, Usuda H, Watanabe S, Sato S, Hanita T, et al. The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy. Am J Obstet Gynecol. 2018;219:301.e301-301.e316. https://doi.org/10.1016/j.ajog.2018.05.007.

Article  CAS  Google Scholar 

Kemp MW, Saito M, Schmidt AF, Usuda H, Watanabe S, Sato S, et al. The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation. Am J Obstet Gynecol. 2020;222:183.e181-183.e189. https://doi.org/10.1016/j.ajog.2019.08.046.

Article  CAS  Google Scholar 

Bal MP, de Vries WB, van der Leij FR, van Oosterhout MF, Berger RM, Baan J, et al. Neonatal glucocorticosteroid treatment causes systolic dysfunction and compensatory dilation in early life: studies in 4-week-old prepubertal rats. Pediatr Res. 2005;58:46–52. https://doi.org/10.1203/01.Pdr.0000163617.01673.9a.

Article  CAS  PubMed  Google Scholar 

De Vries WB. Alterations in adult rat heart after neonatal dexamethasone therapy. Pediatr Res. 2002;52:900–6. https://doi.org/10.1203/01.Pdr.0000036281.74804.27.

Article  PubMed  Google Scholar 

Kuo AH, Li J, Li C, Huber HF, Schwab M, Nathanielsz PW, et al. Prenatal steroid administration leads to adult pericardial and hepatic steatosis in male baboons. Int J Obes (Lond). 2017;41:1299–302. https://doi.org/10.1038/ijo.2017.82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doyle LW, Ford GW, Davis NM, Callanan C. Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children. Clin Sci. 2000;98:137–42. https://doi.org/10.1042/Cs19990211.

Article  CAS  Google Scholar 

Nixon PA, Washburn LK, Michael O’Shea T, Shaltout HA, Russell GB, Snively BM, et al. Antenatal steroid exposure and heart rate variability in adolescents born with very low birth weight. Pediatr Res. 2017;81:57–62. https://doi.org/10.1038/pr.2016.173.

Article  CAS  PubMed  Google Scholar 

Ren R, Oakley RH, Cruz-Topete D, Cidlowski JA. Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis. Endocrinology. 2012;153:5346–60. https://doi.org/10.1210/en.2012-1563.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Severinova E, Alikunju S, Deng W, Dhawan P, Sayed N, Sayed D. Glucocorticoid receptor-binding and transcriptome signature in cardiomyocytes. J Am Heart Assoc. 2019;8:e011484. https://doi.org/10.1161/JAHA.118.011484.

Article  PubMed  PubMed Central  Google Scholar 

Kemp MW, Molloy TJ, Usuda H, Woodward E, Miura Y, Payne MS, et al. Outside-in? Acute fetal systemic inflammation in very preterm chronically catheterized sheep fetuses is not driven by cells in the fetal blood. Am J Obstet Gynecol. 2016;214:281.e281-281.e210. https://doi.org/10.1016/j.ajog.2015.09.076.

Article  Google Scholar 

da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using david bioinformatics resources. Nat Protoc. 2009;4:44–57. https://doi.org/10.1038/nprot.2008.211.

Article  CAS  PubMed  Google Scholar 

Derks JB, Giussani DA, Jenkins SL, Wentworth RA, Visser GH, Padbury JF, et al. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol. 1997;499(Pt 1):217–26. https://doi.org/10.1113/jphysiol.1997.sp021922.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ervin MG, Berry LM, Ikegami M, Jobe AH, Padbury JF, Polk DH. Single dose fetal betamethasone administration stabilizes postnatal glomerular filtration rate and alters endocrine function in premature lambs. Pediatr Res. 1996;40:645–51. https://doi.org/10.1203/00006450-199611000-00001.

Article  CAS  PubMed  Google Scholar 

Omar SA, DeCristofaro JD, Agarwal BI, La Gamma EF. Effects of prenatal steroids on water and sodium homeostasis in extremely low birth weight neonates. Pediatrics. 1999;104:482–8. https://doi.org/10.1542/peds.104.3.482.

Article  CAS  PubMed  Google Scholar 

Ekin A, Gezer C, Solmaz U, Taner CE, Ozeren M, Dogan A, et al. Effect of antenatal betamethasone administration on doppler velocimetry of fetal and uteroplacental vessels: a prospective study. J Perinat Med. 2016;44:243–8. https://doi.org/10.1515/jpm-2015-0194.

Article  CAS  PubMed  Google Scholar 

Urban R, Lemancewicz A, Przepiesc J, Urban J, Kretowska M. Antenatal corticosteroid therapy: a comparative study of dexamethasone and betamethasone effects on fetal Doppler flow velocity waveforms. Eur J Obstet Gynecol Reprod Biol. 2005;120:170–4. https://doi.org/10.1016/j.ejogrb.2004.09.009.

Article  CAS  PubMed  Google Scholar 

Wyrwoll CS, Noble J, Thomson A, Tesic D, Miller MR, Rog-Zielinska EA, et al. Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess. Proc Natl Acad Sci U S A. 2016;113:6265–70. https://doi.org/10.1073/pnas.1520356113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dervisoglu P, Kosecik M, Kumbasar S. Effects of gestational and pregestational diabetes mellitus on the foetal heart: a cross-sectional study. J Obstet Gynaecol. 2018;38:408–12. https://doi.org/10.1080/01443615.2017.1410536.

Article  PubMed  Google Scholar 

Harada K, Rice MJ, Shiota T, Ishii M, McDonald RW, Reller MD, et al. Gestational age- and growth-related alterations in fetal right and left ventricular diastolic filling patterns. Am J Cardiol. 1997;79:173–7. https://doi.org/10.1016/s0002-9149(96)00706-0.

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