Kumar S (2020) A brief review of the biological potential of indole derivatives. Future J Pharm Sci 6(1):1–19

CAS  Google Scholar 

Van Order R, Lindwall H (1942) Indole. Chem Rev 30(1):69–96

Article  Google Scholar 

Kumari A, Singh RK (2019) Medicinal chemistry of indole derivatives: current to future therapeutic prospectives. Bioorgn Chem 89:103021

Article  CAS  Google Scholar 

Jia Y et al (2020) Current scenario of indole derivatives with potential anti-drug-resistant cancer activity. Eur J Med Chem 200:112359

Article  CAS  PubMed  Google Scholar 

Kaushik NK et al (2013) Biomedical importance of indoles. Molecules 18(6):6620–6662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shaker AM et al (2020) Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities. BMC Chem 14(1):1–15

Article  Google Scholar 

Al-Ostoot FH et al (2020) Design-based synthesis, molecular docking analysis of an anti-inflammatory drug, and geometrical optimization and interaction energy studies of an indole acetamide derivative. J Mol Struct 1202:127244

Article  CAS  Google Scholar 

Reddy GS, Pal M (2021) Indole derivatives as anti-tubercular agents: an overview on their synthesis and biological activities. Curr Med Chem 28(22):4531–4568

Article  CAS  PubMed  Google Scholar 

Thanikachalam PV et al (2019) An insight into the medicinal perspective of synthetic analogs of indole: a review. Eur J Med Chem 180:562–612

Article  CAS  PubMed  Google Scholar 

Khan A et al (2018) Enhancement in anti-tubercular activity of indole based thiosemicarbazones on complexation with copper (I) and silver (I) halides: structure elucidation, evaluation and molecular modelling. Bioorgn Chem 80:303–318

Article  CAS  Google Scholar 

Nomura S et al (2014) Novel indole-N-glucoside, TA-1887 as a sodium glucose cotransporter 2 inhibitor for treatment of type 2 diabetes. ACS Med Chem Lett 5(1):51–55

Article  CAS  PubMed  Google Scholar 

Omar F et al (2021) Plant-based indole alkaloids: a comprehensive overview from a pharmacological perspective. Molecules 26(8):2297

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Salahi R et al (2018) Screening and evaluation of antioxidant activity of some 1, 2, 4-triazolo [1, 5-a] quinazoline derivatives. Future Med Chem 10(4):379–390

Article  CAS  PubMed  Google Scholar 

Bentz EN et al (2018) Intrinsic antioxidant potential of the aminoindole structure: a computational kinetics study of tryptamine. J Phys Chem B 122(24):6386–6395

Article  CAS  PubMed  Google Scholar 

Dadashpour S, Emami S (2018) Indole in the target-based design of anticancer agents: a versatile scaffold with diverse mechanisms. Eur J Med Chem 150:9–29

Article  CAS  PubMed  Google Scholar 

Dhiman A, Sharma R, Singh RK (2022) Target-based anticancer indole derivatives and insight into structure-activity relationship: a mechanistic review update (2018–2021). Acta Pharm Sin B. https://doi.org/10.1016/j.apsb.2022.03.021

Article  PubMed  PubMed Central  Google Scholar 

Balakrishnan N et al (2023) Influence of Indole-N substitution of thiosemicarbazones in cationic Ru (II)(η6-Benzene) complexes on their anticancer activity. Organometallics 42(3):259–275

Article  CAS  Google Scholar 

Ali I et al (2018) Facile synthesis of indole heterocyclic compounds based micellar nano anti-cancer drugs. RSC Adv 8(66):37905–37914

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bingul M, Ercan S, Boga M (2020) The design of novel 4, 6-dimethoxyindole based hydrazide-hydrazones: Molecular modeling, synthesis and anticholinesterase activity. J Mol Struct 1213:128202

Article  CAS  Google Scholar 

Mahmoud E et al (2022) Recent progress in biologically active indole hybrids: a mini review. Pharmacol Rep 74(4):570–582

Article  CAS  PubMed  Google Scholar 

Sulthana S, Pandian P (2019) A review on Indole and Benzothiazole derivatives its importance. J Drug Deliv Ther 9(1-s):505–509

Article  CAS  Google Scholar 

Chadha N, Silakari O (2018) Indoles: as multitarget directed ligands in medicinal chemistry. In: Key heterocycle cores for designing multitargeting molecules, Elsevier, pp 285–321

Ramesh D et al (2020) Indole chalcones: design, synthesis, in vitro and in silico evaluation against Mycobacterium tuberculosis. Eur J Med Chem 198:112358

Article  CAS  PubMed  Google Scholar 

Namasivayam V et al (2018) The journey of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) from lab to clinic. J Med Chem 62(10):4851–4883

Article  PubMed  PubMed Central  Google Scholar 

Lynch SM, Bur SK, Padwa A (2002) Intramolecular amidofuran cycloadditions across an indole π-bond: an efficient approach to the aspidosperma and strychnos ABCE core. Org Lett 4(26):4643–4645

Article  CAS  PubMed  Google Scholar 

Bergman J, Venemalm L (1992) Efficient synthesis of 2-chloro-, 2-bromo-, and 2-iodoindole. J Org Chem 57(8):2495–2497

Article  CAS  Google Scholar 

Ximenes VF, Campa A, Catalani LH (2001) The oxidation of indole derivatives catalyzed by horseradish peroxidase is highly chemiluminescent. Arch Biochem Biophys 387(2):173–179

Article  CAS  PubMed  Google Scholar 

Shabica A et al (1946) Improved syntheses of indole-3-aldehyde. J Am Chem Soc 68(7):1156–1157

Article  CAS  Google Scholar 

Ma Q, Zhang X, Qu Y (2018) Biodegradation and biotransformation of indole: advances and perspectives. Front Microbiol 9:2625

Article  PubMed  PubMed Central  Google Scholar 

Chadha N, Silakari O (2017) Indoles as therapeutics of interest in medicinal chemistry: bird’s eye view. Eur J Med Chem 134:159–184

Article  CAS  PubMed  Google Scholar 

Apaydın S, Török M (2019) Sulfonamide derivatives as multi-target agents for complex diseases. Bioorgn Med Chem Lett 29(16):2042–2050

Article  Google Scholar 

Ovung A, Bhattacharyya J (2021) Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions. Biophys Rev 13(2):259–272

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taha M et al (2021) Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin–induced diabetic albino wistar rats. Bioorgn Chem 110:104808

Article  CAS  Google Scholar 

Chohan ZH et al (2010) Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. Eur J Med Chem 45(3):1189–1199

Article  CAS  PubMed  Google Scholar 

Garaj V et al (2005) Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1, 3, 5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX. Bioorgn Med Chem Lett 15(12):3102–3108

Article  CAS  Google Scholar 

Verma SK et al (2020) Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: a critical review. Bioorgn Chem 105:104400

Article  Google Scholar 

Nirogi RV et al (2011) Indole-3-piperazinyl derivatives: novel chemical class of 5-HT6 receptor antagonists. Bioorgn Med Chem Lett 21(1):346–349

Article  CAS  Google Scholar 

Anilkumar GN et al (2012) II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides. Bioorgn Med Chem Lett 22(1):713–717

Article  CAS  Google Scholar 

Pingaew R et al (2013) Synthesis and structure–activity relationship of mono-indole-, bis-indole-, and tris-indole-based sulfonamides as potential anticancer agents. Mol Divers 17:595–604

Article  CAS  PubMed  Google Scholar 

Ahmed A et al (2023) Synthesis and spectroscopic characterization of nicotinaldehyde based derivatives: SC-XRD, linear and non-linear optical studies. J Mol Struct 1273:134236

Article  CAS  Google Scholar 

Li Y-H et al (2014) Asymmetric synthesis of 3-substituted indole derivatives containing tetrahydrothiophene via cascade sulfa-Michael/Michael additions catalyzed by a chiral squaramide catalyst. Tetrahedron Asymmetry 25(23):1513–1519

Article  CAS  Google Scholar 

Alemán J et al (2011) Squaramides: bridging from molecular recognition to bifunctional organocatalysis. Chem A Eur J 17(25):6890–6899