Menke J, Lüthje L, Kastrup A, Larsen J. Thromboembolism in atrial fibrillation. Am J Cardiol. 2010;105(4):502–10. https://doi.org/10.1016/j.amjcard.2009.10.018.

Article  PubMed  Google Scholar 

Pandian JD, Gall SL, Kate MP, Silva GS, Akinyemi RO, Ovbiagele BI, Lavados PM, Gandhi DBC, Thrift AG. Prevention of stroke: a global perspective. Lancet. 2018;392(10154):1269–78. https://doi.org/10.1016/s0140-6736(18)31269-8.

Article  PubMed  Google Scholar 

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021;42(5):373–498.

Article  PubMed  Google Scholar 

Chan N, Sobieraj-Teague M, Eikelboom JW. Direct oral anticoagulants: evidence and unresolved issues. Lancet. 2020;396(10264):1767–76. https://doi.org/10.1016/s0140-6736(20)32439-9.

Article  CAS  PubMed  Google Scholar 

Skurk C, Landmesser U. Left atrial appendage occlusion for stroke prevention - state of the art as provided in an updated EHRA/EAPCI consensus statement and future perspectives. EuroIntervention. 2020;15(13):1117–9. https://doi.org/10.4244/eijv15i13a207.

Article  PubMed  Google Scholar 

Glikson M, Wolff R, Hindricks G, Mandrola J, Camm AJ, Lip GYH, Fauchier L, Betts TR, Lewalter T, Saw J, Tzikas A, Sternik L, Nietlispach F, Berti S, Sievert H, Bertog S, Meier B, ESC Scientific Document Group. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. Europace. 2020;22(2):184. https://doi.org/10.1093/europace/euz258.

Alkhouli M, Busu T, Shah K, Osman M, Alqahtani F, Raybuck B. Incidence and clinical impact of device-related thrombus following percutaneous left atrial appendage occlusion: a meta-analysis. JACC Clin Electrophysiol. 2018;4(12):1629–37. https://doi.org/10.1016/j.jacep.2018.09.007.

Article  PubMed  Google Scholar 

Kaneko H, Neuss M, Weissenborn J, Butter C. Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device. Heart Vessels. 2017;32(9):1137–43. https://doi.org/10.1007/s00380-017-0971-x.

Article  PubMed  Google Scholar 

Dukkipati SR, Kar S, Holmes DR, Doshi SK, Swarup V, Gibson DN, Maini B, Gordon NT, Main ML, Reddy VY. Device-related thrombus after left atrial appendage closure: incidence, predictors, and outcomes. Circulation. 2018;138(9):874–85. https://doi.org/10.1161/circulationaha.118.035090.

Article  PubMed  Google Scholar 

Pracon R, Bangalore S, Dzielinska Z, Konka M, Kepka C, Kruk M, Kaczmarska-Dyrda E, Petryka-Mazurkiewicz J, Bujak S, Solecki M, Pskit A, Dabrowska A, Sieradzki B, Plonski A, Ruzyllo W, Witkowski A, Demkow M. Device thrombosis after percutaneous left atrial appendage occlusion is related to patient and procedural characteristics but not to duration of postimplantation dual antiplatelet therapy. Circ Cardiovasc Interv. 2018;11(3):e005997. https://doi.org/10.1161/circinterventions.117.005997.

Article  PubMed  Google Scholar 

Ito T, Suwa M. Left atrial spontaneous echo contrast: relationship with clinical and echocardiographic parameters. Echo Res Pract. 2019;6(2):R65-r73. https://doi.org/10.1530/erp-18-0083.

Article  PubMed  PubMed Central  Google Scholar 

Backhaus JF, Pflaumbaum A, Krogias C, Kreimer F, Mügge A, Gold R, Gotzmann M. Short- and long-term outcome of patients with spontaneous echo contrast or thrombus in the left atrial appendage in the era of the direct acting anticoagulants. Clin Res Cardiol. 2021;110(11):1811–21. https://doi.org/10.1007/s00392-021-01926-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brachmann J, Lewalter T, Akin I, Sievert H, Geist V, Zeymer U, Erkapic D, Mudra H, Pleger S, Hochadel M, Senges J. Interventional occlusion of left atrial appendage in patients with atrial fibrillation. Acute and long-term outcome of occluder implantation in the LAARGE Registry. J Interv Card Electrophysiol. 2020;58(3):273–80. https://doi.org/10.1007/s10840-019-00635-7.

Article  PubMed  Google Scholar 

Fatkin D, Kelly RP, Feneley MP. Relations between left atrial appendage blood flow velocity, spontaneous echocardiographic contrast and thromboembolic risk in vivo. J Am Coll Cardiol. 1994;23(4):961–9. https://doi.org/10.1016/0735-1097(94)90644-0.

Article  CAS  PubMed  Google Scholar 

Tzikas A, Shakir S, Gafoor S, Omran H, Berti S, Santoro G, Kefer J, Landmesser U, Nielsen-Kudsk JE, Cruz-Gonzalez I, Sievert H, Tichelbäcker T, Kanagaratnam P, Nietlispach F, Aminian A, Kasch F, Freixa X, Danna P, Rezzaghi M, Vermeersch P, Stock F, Stolcova M, Costa M, Ibrahim R, Schillinger W, Meier B, Park JW. Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER Cardiac Plug. EuroIntervention. 2016;11(10):1170–9. https://doi.org/10.4244/eijy15m01_06.

Article  PubMed  Google Scholar 

Landmesser U, Tondo C, Camm J, Diener HC, Paul V, Schmidt B, Settergren M, Teiger E, Nielsen-Kudsk JE, Hildick-Smith D. Left atrial appendage occlusion with the AMPLATZER Amulet device: one-year follow-up from the prospective global Amulet observational registry. EuroIntervention. 2018;14(5):e590–7. https://doi.org/10.4244/eij-d-18-00344.

Article  PubMed  Google Scholar 

Beppu S, Nimura Y, Sakakibara H, Nagata S, Park YD, Izumi S. Smoke-like echo in the left atrial cavity in mitral valve disease: its features and significance. J Am Coll Cardiol. 1985;6(4):744–9. https://doi.org/10.1016/s0735-1097(85)80476-9.

Article  CAS  PubMed  Google Scholar 

Seidl K, Rameken M, Drögemüller A, Vater M, Brandt A, Schwacke H, Bergmeier C, Zahn R, Senges J. Embolic events in patients with atrial fibrillation and effective anticoagulation: value of transesophageal echocardiography to guide direct-current cardioversion. Final results of the ludwigshafen observational cardioversion study. J Am Coll Cardiol. 2002;39(9):1436–42. https://doi.org/10.1016/s0735-1097(02)01785-0.

Article  PubMed  Google Scholar 

Yoo J, Song D, Baek JH, Kim YD, Nam HS, Hong GR, Kim J, Lee HS, Heo JH. Poor outcome of stroke patients with atrial fibrillation in the presence of coexisting spontaneous echo contrast. Stroke. 2016;47(7):1920–2. https://doi.org/10.1161/strokeaha.116.013351.

Article  PubMed  Google Scholar 

Bergmann MW, Ince H, Kische S, Schmitz T, Meincke F, Schmidt B, Foley D, Betts TR, Grygier M, Protopopov AV, Stein KM, Boersma LVA. Real-world safety and efficacy of WATCHMAN LAA closure at one year in patients on dual antiplatelet therapy: results of the DAPT subgroup from the EWOLUTION all-comers study. EuroIntervention. 2018;13(17):2003–11. https://doi.org/10.4244/eij-d-17-00672.

Article  PubMed  Google Scholar 

Boersma LV, Ince H, Kische S, Pokushalov E, Schmitz T, Schmidt B, Gori T, Meincke F, Protopopov AV, Betts T, Foley D, Sievert H, Mazzone P, De Potter T, Vireca E, Stein K, Bergmann MW. Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-year follow-up outcome data of the EWOLUTION trial. Heart Rhythm. 2017;14(9):1302–8. https://doi.org/10.1016/j.hrthm.2017.05.038.

Article  PubMed  Google Scholar 

Alkhouli M, Du C, Killu A, Simard T, Noseworthy PA, Friedman PA, Curtis JP, Freeman JV, Holmes DR. Clinical impact of residual leaks following left atrial appendage occlusion: insights from the NCDR LAAO Registry. JACC Clin Electrophysiol. 2022;8(6):766–78. https://doi.org/10.1016/j.jacep.2022.03.001.

Article  PubMed  PubMed Central  Google Scholar 

Boersma LV, Schmidt B, Betts TR, Sievert H, Tamburino C, Teiger E, Pokushalov E, Kische S, Schmitz T, Stein KM, Bergmann MW. Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry. Eur Heart J. 2016;37(31):2465–74. https://doi.org/10.1093/eurheartj/ehv730.

Article  PubMed  PubMed Central  Google Scholar 

Messele LF, Khan MZ, Darden D, Agarwal S, Krishan S, Pasupula DK, Asad ZUA, Balla S, Singh GD, Srivatsa UN, Munir MB. Outcomes of percutaneous left atrial appendage occlusion device implantation in atrial fibrillation patients based on underlying stroke risk. Europace. 2023. https://doi.org/10.1093/europace/euad049.

Article  PubMed  PubMed Central  Google Scholar 

Freeman JV, Varosy P, Price MJ, Slotwiner D, Kusumoto FM, Rammohan C, Kavinsky CJ, Turi ZG, Akar J, Koutras C, Curtis JP, Masoudi FA. The NCDR left atrial appendage occlusion registry. J Am Coll Cardiol. 2020;75(13):1503–18. https://doi.org/10.1016/j.jacc.2019.12.040.

Article  PubMed  PubMed Central  Google Scholar 

Sedaghat A, Vij V, Al-Kassou B, Gloekler S, Galea R, Fürholz M, Meier B, Valgimigli M, O’Hara G, Arzamendi D, Agudelo V, Asmarats L, Freixa X, Flores-Umanzor E, De Backer O, Søndergaard L, Nombela-Franco L, McInerney A, Korsholm K, Nielsen-Kudsk JE, Afzal S, Zeus T, Operhalski F, Schmidt B, Montalescot G, Guedeney P, Iriart X, Miton N, Saw J, Gilhofer T, Fauchier L, Veliqi E, Meincke F, Petri N, Nordbeck P, Rycerz S, Ognerubov D, Merkulov E, Cruz-González I, Gonzalez-Ferreiro R, Bhatt DL, Laricchia A, Mangieri A, Omran H, Schrickel JW, Rodes-Cabau J, Nickenig G. Device-related thrombus after left atrial appendage closure: data on thrombus characteristics, treatment strategies, and clinical outcomes from the EUROC-DRT-registry. Circ Cardiovasc Interv. 2021;14(5):e010195. https://doi.org/10.1161/circinterventions.120.010195.

Article  PubMed  Google Scholar 

Simard T, Jung RG, Lehenbauer K, Piayda K, Pracoń R, Jackson GG, Flores-Umanzor E, Faroux L, Korsholm K, Chun JKR, Chen S, Maarse M, Montrella K, Chaker Z, Spoon JN, Pastormerlo LE, Meincke F, Sawant AC, Moldovan CM, Qintar M, Aktas MK, Branca L, Radinovic A, Ram P, El-Zein RS, Flautt T, Ding WY, Sayegh B, Benito-González T, Lee OH, Badejoko SO, Paitazoglou C, Karim N, Zaghloul AM, Agrawal H, Kaplan RM, Alli O, Ahmed A, Suradi HS, Knight BP, Alla VM, Panaich SS, Wong T, Bergmann MW, Chothia R, Kim JS, Pérez de Prado A, Bazaz R, Gupta D, Valderrabano M, Sanchez CE, El Chami MF, Mazzone P, Adamo M, Ling F, Wang DD, O’Neill W, Wojakowski W, Pershad A, Berti S, Spoon D, Kawsara A, Jabbour G, Boersma LVA, Schmidt B, Nielsen-Kudsk JE, Rodés-Cabau J, Freixa X, Ellis CR, Fauchier L, Demkow M, Sievert H, Main ML, Hibbert B, Holmes DR Jr, Alkhouli M. Predictors of device-related thrombus following percutaneous left atrial appendage occlusion. J Am Coll Cardiol. 2021;78(4):297–313. https://doi.org/10.1016/j.jacc.2021.04.098.

Article  PubMed  Google Scholar 

Sedaghat A, Nickenig G, Schrickel JW, Ince H, Schmidt B, Protopopov AV, Betts TR, Gori T, Sievert H, Mazzone P, Grygier M, Wald C, Vireca E, Allocco D, Boersma LVA. Incidence, predictors and outcomes of device-related thrombus after left atrial appendage closure with the WATCHMAN device-Insights from the EWOLUTION real world registry. Catheter Cardiovasc Interv. 2021;97(7):E1019-e1024. https://doi.org/10.1002/ccd.29458.

Article  PubMed  Google Scholar 

Holmes DR, Reddy VY, Turi ZG, Doshi SK, Sievert H, Buchbinder M, Mullin CM, Sick P. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet. 2009;374(9689):534–42. https://doi.org/10.1016/s0140-6736(09)61343-x.

Article  CAS  PubMed  Google Scholar 

Ledwoch J, Staubach S, Akin I, Ince H, Zeymer U, Pleger S, Sievert H, Hochadel M, Senges J, Lewalter T, Brachmann J, Mudra H. Anticoagulation versus antiplatelet therapy after percutaneous left atrial appendage closure-subanalysis from the multicenter LAARGE registry. J Interv Card Electrophysiol. 2021. https://doi.org/10.1007/s10840-021-01080-1.

Article  PubMed  Google Scholar 

Ganguli M, Lytle ME, Reynolds MD, Dodge HH. Random versus volunteer selection for a community-based study. J Gerontol A Biol Sci Med Sci. 1998;53(1):M39-46. https://doi.org/10.1093/gerona/53a.1.m39.

Article  CAS