Antiviral and anti-inflammatory effects of Avrocil (THG Ltd.): An in-vitro study of a novel herbal compound

Human rhinoviruses (HRV) comprise several serotypes, many of which cause the common cold in humans (Royston and Tapparel, 2016, Tan et al., 2017, Holland et al., 1982).

The nasal epithelium is the initial entry site for respiratory viruses, serving as a direct target for the replication of viruses in the respiratory tract (Tan et al., 2017). In vitro studies involving human bronchial epithelial cells have shown that HRV-16 targets ciliated cells, with additional experiments demonstrating the triggering of an immune cascade, and affecting the entire airway (Jakiela et al., 2014, Miyauchi, 2017). Several medications are available to treat HRV-16 and other upper respiratory tract infections (URTIs), including neuraminidase inhibitors and amantadine (Novartis) (Calfee and Hayden, 1998, Hay et al., 1985). However, associated complications and side effects have prompted research into different products, including plant-based compounds and their derivatives.

Some plants have properties against viruses that cause URTIs (Jassim and Naji, 2003). One such formulation is Avrocil (THG Ltd.), a new plant-based herbal product which contains Lithospermum erythrorhizon, Siraitia grosvenorii, Chrysanthemum Indicum, Artemisia annua, Prunella vulgaris, and Lophatherum gracile. Avrocil (THG Ltd.). It is natural, gentle, and effectively aids the body to fight against the common cold and flu viruses. Each component in Avrocil (THG Ltd.) has been tested separately in prievious studies, and has shown varying levels of efficacy against viruses. Some examples include the immune modulation associated with Lithospermum erythrorhizon’s (Chen et al., 2003) and Chrysanthemum Indicum's anti-oxidative properties (Debnath et al., 2013). However, most of these herbal components are not well studied in their activity against HRV and other viruses.

This study aims to investigate the antiviral and antiinflammatory effects of Avrocil (THG Ltd.) by using an HRV-16-infected airway epithelial model. Specific aims include the following: (a) optimizing herbal extraction for in vitro tests, (b) determining the reduction in HRV viral load, and (c) studying the antiinflammatory effects of Avrocil (THG Ltd.) extracts.

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