PDZD8-mediated endoplasmic reticulum–mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension

Keywords

Endoplasmic reticulum–mitochondria associations

Mitochondrial dysfunction

PDZD8

Rostral ventrolateral medulla

Stress-induced hypertension

AbbreviationsAAV

adeno-associated virus

ERMCs

endoplasmic reticulum–mitochondria contact sites

MAP

mean arterial pressure

MMP

mitochondrial membrane potential

RAS

renin-angiotensin system

ROS

reactive oxygen species

RSNA

renal sympathetic nerve activity

RSNS

renal sympathetic nerve system

RVLM

rostral ventrolateral medulla

RT-qPCR

reverse transcription quantitative polymerase chain reaction

SBP

systolic blood pressure

SIH

stress-induced hypertension

TEM

transmission electron microscopy

Data availability

Data available on reasonable request from the corresponding author.

© 2023 The Authors. Published by Elsevier Inc.

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