Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102–11.

Article  PubMed  Google Scholar 

Forsmark CE, Vege SS, Wilcox CM. Acute pancreatitis. N Engl J Med. 2016;375:1972–81.

Article  CAS  PubMed  Google Scholar 

Jung B, Carr J, Chanques G, Cisse M, Perrigault P-F, Savey A, et al. Severe and acute pancreatitis admitted in intensive care: a prospective epidemiological multiple centre study using CClin network database. Ann Fr Anesth Reanim. 2011;30:105–12.

Article  CAS  PubMed  Google Scholar 

Darrivere L, Lapidus N, Colignon N, Chafai N, Chaput U, Verdonk F, et al. Minimally invasive drainage in critically ill patients with severe necrotizing pancreatitis is associated with better outcomes: an observational study. Crit Care. 2018;22:321.

Article  PubMed  PubMed Central  Google Scholar 

Tenner S, Baillie J, DeWitt J, Vege SS, American College of Gastroenterology. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013;108:1400–15; 1416.

Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013;13:e1-15.

Article  Google Scholar 

Leppäniemi A, Tolonen M, Tarasconi A, Segovia-Lohse H, Gamberini E, Kirkpatrick AW, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg. 2019;14:27.

Article  PubMed  PubMed Central  Google Scholar 

Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN, American Gastroenterological Association Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis. Gastroenterology. 2018;154:1096–101.

Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, et al. Acute pancreatitis. Lancet. 2020;396:726–34.

Article  PubMed  Google Scholar 

Jaber S, Garnier M, Asehnoune K, Bounes F, Buscail L, Chevaux J-B, et al. Guidelines for the management of patients with severe acute pancreatitis, 2021. Anaesthesia Crit Care Pain Med. 2022;41: 101060.

Article  Google Scholar 

Sauder P, Andreoletti M, Cambonie G, Capellier G, Feissel M, Gall O, et al. Sedation and analgesia in intensive care (with the exception of new-born babies). French Society of Anesthesia and Resuscitation. French-speaking Resuscitation Society. Ann Fr Anesth Reanim. 2008;27:541–51.

Article  CAS  PubMed  Google Scholar 

Windisch O, Heidegger C-P, Giraud R, Morel P, Bühler L. Thoracic epidural analgesia: A new approach for the treatment of acute pancreatitis? Crit Care. 2016;20:116.

Article  PubMed  PubMed Central  Google Scholar 

Bernhardt A, Kortgen A, Niesel HC, Goertz A. Using epidural anesthesia in patients with acute pancreatitis–prospective study of 121 patients. Anaesthesiol Reanim. 2002;27:16–22.

CAS  PubMed  Google Scholar 

Jabaudon M, Chabanne R, Sossou A, Bertrand P-M, Kauffmann S, Chartier C, et al. Epidural analgesia in the intensive care unit: an observational series of 121 patients. Anaesth Crit Care Pain Med. 2015;34:217–23.

Article  PubMed  Google Scholar 

Jabaudon M, Belhadj-Tahar N, Rimmelé T, Joannes-Boyau O, Bulyez S, Lefrant J-Y, et al. Thoracic epidural analgesia and mortality in acute pancreatitis: a multicenter propensity analysis. Crit Care Med. 2018;46:e198-205.

Article  PubMed  Google Scholar 

Sadowski SM, Andres A, Morel P, Schiffer E, Frossard J-L, Platon A, et al. Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis. World J Gastroenterol. 2015;21:12448–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yehya N, Harhay MO, Curley MAQ, Schoenfeld DA, Reeder RW. Reappraisal of ventilator-free days in critical care research. Am J Respir Crit Care Med. 2019;200:828–36.

Article  PubMed  PubMed Central  Google Scholar 

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, et al. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med. 2019;380:1997–2008.

Bulyez S, Pereira B, Caumon E, Imhoff E, Roszyk L, Bernard L, et al. Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol. BMJ Open. 2017;7: e015280.

Article  PubMed  PubMed Central  Google Scholar 

Payen JF, Bru O, Bosson JL, Lagrasta A, Novel E, Deschaux I, et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med. 2001;29:2258–63.

Article  CAS  PubMed  Google Scholar 

Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377–81.

Article  PubMed  Google Scholar 

Demirag A, Pastor CM, Morel P, Jean-Christophe C, Sielenkämper AW, Güvener N, et al. Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis. World J Gastroenterol. 2006;12:915–20.

Article  PubMed  PubMed Central  Google Scholar 

Freise H, Lauer S, Anthonsen S, Hlouschek V, Minin E, Fischer LG, et al. Thoracic epidural analgesia augments ileal mucosal capillary perfusion and improves survival in severe acute pancreatitis in rats. Anesthesiology. 2006;105:354–9.

Article  CAS  PubMed  Google Scholar 

Lauer S, Freise H, Fischer LG, Singbartl K, Aken HV, Lerch MM, et al. The role of thoracic epidural analgesia in receptor-dependent and receptor-independent pulmonary vasoconstriction in experimental pancreatitis. Anesth Analg. 2007;105:453–9.

Article  CAS  PubMed  Google Scholar 

Schäper J, Wagner A, Enigk F, Brell B, Mousa SA, Habazettl H, et al. Regional sympathetic blockade attenuates activation of intestinal macrophages and reduces gut barrier failure. Anesthesiology. 2013;118:134–42.

Article  PubMed  Google Scholar 

Bachmann KA, Trepte CJC, Tomkötter L, Hinsch A, Stork J, Bergmann W, et al. Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial. Crit Care. 2013;17:R281.

Article  PubMed  PubMed Central  Google Scholar 

Enigk F, Wagner A, Samapati R, Rittner H, Brack A, Mousa SA, et al. Thoracic epidural anesthesia decreases endotoxin-induced endothelial injury. BMC Anesthesiol. 2014;14:23.

Article  PubMed  PubMed Central  Google Scholar 

Tyagi A, Gupta YR, Das S, Rai G, Gupta A. Effect of segmental thoracic epidural block on pancreatitisinduced organ dysfunction: a preliminary study. Indian J Crit Care Med. 2019;23:89–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pettilä V, Kyhälä L, Kylänpää M-L, Leppäniemi A, Tallgren M, Markkola A, et al. APCAP–activated protein C in acute pancreatitis: a double-blind randomized human pilot trial. Crit Care. 2010;14:R139.

Article  PubMed  PubMed Central  Google Scholar 

Mounzer R, Langmead CJ, Wu BU, Evans AC, Bishehsari F, Muddana V, et al. Comparison of existing clinical scoring systems to predict persistent organ failure in patients with acute pancreatitis. Gastroenterology. 2012;142:1476–82; quiz e15–6.

Bakker OJ, van Brunschot S, van Santvoort HC, Besselink MG, Bollen TL, Boermeester MA, et al. Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med. 2014;371:1983–93.

Article  CAS  PubMed  Google Scholar 

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–29.

Article  CAS  PubMed  Google Scholar 

van Santvoort HC, Besselink MG, Bakker OJ, Hofker HS, Boermeester MA, Dejong CH, et al. A step-up approach or open necrosectomy for necrotizing pancreatitis. N Engl J Med. 2010;362:1491–502.

Article  PubMed  Google Scholar 

Bakker OJ, van Santvoort HC, van Brunschot S, Geskus RB, Besselink MG, Bollen TL, et al. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis. JAMA. 2012;307:1053.

Article  CAS  PubMed  Google Scholar 

Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand. 2006;50:265–82.

Article  CAS  PubMed  Google Scholar 

Shi N, Liu T, de la Iglesia-Garcia D, Deng L, Jin T, Lan L, et al. Duration of organ failure impacts mortality in acute pancreatitis. Gut. BMJ; 2020. 604–5.

Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: A new therapeutic indication? Anesthesiology. 2000;93:858–75.

Article  CAS  PubMed  Google Scholar 

Clemente A, Carli F. The physiological effects of thoracic epidural anesthesia and analgesia on the cardiovascular, respiratory and gastrointestinal systems. Minerva Anestesiol. 2008;74:549–63.

CAS  PubMed  Google Scholar 

Tuncel G, Ozalp G, Savli S, Canoler O, Kaya M, Kadiogullari N. Epidural ropivacaine or sufentanil-ropivacaine infusions for post-thoracotomy pain. Eur J Cardiothorac Surg. 2005;28:375–9.

Article  PubMed  Google Scholar