Li Y, Wang X. The role of cullin4B in human cancers. Exp Hematol Oncol. 2017;6:17.

Article  PubMed  PubMed Central  Google Scholar 

Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, et al. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis. Cancer Cell. 2012;22:781–95.

Article  CAS  PubMed  Google Scholar 

Hung MH, Jian YR, Tsao CC, Lin SW, Chuang YH. Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages. Genes Immun. 2014;15:404–12.

Article  CAS  PubMed  Google Scholar 

Qian Y, Yuan J, Hu H, Yang Q, Li J, Zhang S, et al. The CUL4B/AKT/beta-catenin axis restricts the accumulation of myeloid-derived suppressor cells to prohibit the establishment of a tumor-permissive microenvironment. Cancer Res. 2015;75:5070–83.

Article  CAS  PubMed  Google Scholar 

Xu Z, Li L, Qian Y, Song Y, Qin L, Duan Y, et al. Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells. Oncogene. 2019;38:5860–72.

Article  CAS  PubMed  Google Scholar 

Song Y, Li P, Qin L, Xu Z, Jiang B, Ma C, et al. CUL4B negatively regulates toll-like receptor-triggered proinflammatory responses by repressing Pten transcription. Cell Mol Immunol. 2021;18:339–49.

Article  CAS  PubMed  Google Scholar 

Dar AA, Sawada K, Dybas JM, Moser EK, Lewis EL, Park E, et al. The E3 ubiquitin ligase Cul4b promotes CD4+ T-cell expansion by aiding the repair of damaged DNA. PLoS Biol. 2021;19:e3001041.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin L, Song Y, Zhang F, Wang R, Zhou L, Jin S, et al. CRL4B complex-mediated H2AK119 monoubiquitination restrains Th1 and Th2 cell differentiation. Cell Death Differ. 2023; https://doi.org/10.1038/s41418-023-01155-8.

Jin S, Song Y, Zhou L, Jiang W, Qin L, Wang Y, et al. Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell Rep. 2023;42:112550.

Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, et al. Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet. 2007;80:561–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tarpey PS, Raymond FL, O’Meara S, Edkins S, Teague J, Butler A, et al. Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet. 2007;80:345–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zong Y, Shan H, Yin F, Ma X, Jiang C, Wang N, et al. Ddb1-Cullin4-associated-Factor 1 in macrophages restricts the staphylococcus aureus-induced osteomyelitis. J Inflamm Res. 2021;14:1667–76.

Article  PubMed  PubMed Central  Google Scholar 

Yang L, Chen W, Li L, Xiao Y, Fan S, Zhang Q, et al. Ddb1 is essential for the expansion of CD4(+) helper T cells by regulating cell cycle progression and cell death. Front Immunol. 2021;12:722273.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tumes DJ, Onodera A, Suzuki A, Shinoda K, Endo Y, Iwamura C, et al. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells. Immunity. 2013;39:819–32.

Article  CAS  PubMed  Google Scholar