Prophylactic administration of metformin reduces gestational diabetes mellitus incidence in the high-risk populations: a meta-analysis

Sweeting A, Wong J, Murphy HR et al (2022) A Clinical Update on Gestational Diabetes Mellitus. Endocr Rev 43:763–793. https://doi.org/10.1210/endrev/bnac003

Article  PubMed  PubMed Central  Google Scholar 

Juan J, Yang H (2020) Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China. Int J Environ Res Public Health 17. https://doi.org/10.3390/ijerph17249517

Zhu Y, Zhang C (2016) Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: a Global Perspective. Curr Diab Rep 16:7. https://doi.org/10.1007/s11892-015-0699-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buchanan TA, Xiang AH, Page KA (2012) Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8:639–649. https://doi.org/10.1038/nrendo.2012.96

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee KW, Ching SM, Ramachandran V et al (2018) Prevalence and risk factors of gestational diabetes mellitus in Asia: a systematic review and meta-analysis. BMC Pregnancy Childbirth 18:494. https://doi.org/10.1186/s12884-018-2131-4

Article  PubMed  PubMed Central  Google Scholar 

Ye W, Luo C, Huang J et al (2022) Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 377:e067946. https://doi.org/10.1136/bmj-2021-067946

Saravanan P, Diabetes in Pregnancy Working G, Maternal Medicine Clinical Study G et al (2020) Gestational diabetes: opportunities for improving maternal and child health. Lancet Diabetes Endocrinol 8:793–800. https://doi.org/10.1016/S2213-8587(20)30161-3

Benhalima K, Van Crombrugge P, Moyson C et al (2019) Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance. Diabetologia 62:2118–2128. https://doi.org/10.1007/s00125-019-4961-7

Article  CAS  PubMed  Google Scholar 

Moon JH, Jang HC (2022) Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications. Diabetes Metab J 46:3–14. https://doi.org/10.4093/dmj.2021.0335

Article  PubMed  PubMed Central  Google Scholar 

Chatzakis C, Cavoretto P, Sotiriadis A (2021) Gestational Diabetes Mellitus Pharmacological Prevention and Treatment. Curr Pharm Des 27:3833–3840. https://doi.org/10.2174/1381612827666210125155428

Article  CAS  PubMed  Google Scholar 

Huang S, Magny-Normilus C, McMahon E et al (2022) Systematic Review of Lifestyle Interventions for Gestational Diabetes Mellitus in Pregnancy and the Postpartum Period. J Obstet Gynecol Neonatal Nurs 51:115–125. https://doi.org/10.1016/j.jogn.2021.10.007

Article  PubMed  Google Scholar 

Foretz M, Guigas B, Bertrand L et al (2014) Metformin: from mechanisms of action to therapies. Cell Metab 20:953–966. https://doi.org/10.1016/j.cmet.2014.09.018

Article  CAS  PubMed  Google Scholar 

Romero R, Erez O, Huttemann M et al (2017) Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol 217:282–302. https://doi.org/10.1016/j.ajog.2017.06.003

Article  CAS  PubMed  PubMed Central  Google Scholar 

LaMoia TE, Shulman GI (2021) Cellular and Molecular Mechanisms of Metformin Action. Endocr Rev 42:77–96. https://doi.org/10.1210/endrev/bnaa023

Article  PubMed  Google Scholar 

Mai T, Zhang Y, Wu M (2019) Effect of metformin on pregnancy rate and incidence of gestational diabetes mellitus in overweight/obese patients with polycystic ovary syndrome. Journal of Inner Mongolia Medical University 41:74–77

Google Scholar 

Qu X, Chen Y, Li H et al (2016) The preventive effect of early metformin administration on gestational diabetes mellitus in obese patients with pregnancy and the effect on fetal weight. Progress in Modern Biomedicine 16:6894–6897. https://doi.org/10.13241/j.cnki.pmb.2016.35.025

Dodd JM, Louise J, Deussen AR et al (2019) Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 7:15–24. https://doi.org/10.1016/S2213-8587(18)30310-3

Article  CAS  PubMed  Google Scholar 

Fougner KJ, Vanky E, Carlsen SM (2008) Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double-blind study. Scand J Clin Lab Invest 68:771–776. https://doi.org/10.1080/00365510802254620

Article  CAS  PubMed  Google Scholar 

Doi SAR, Furuya-Kanamori L, Toft E et al (2020) Metformin in pregnancy to avert gestational diabetes in women at high risk: Meta-analysis of randomized controlled trials. Obes Rev 21:e12964. https://doi.org/10.1111/obr.12964

Nawaz FH, Khalid R, Naru T et al (2008) Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome? J Obstet Gynaecol Res 34:832–837. https://doi.org/10.1111/j.1447-0756.2008.00856.x

Article  PubMed  Google Scholar 

Nawaz FH, Rizvi J (2010) Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome. Gynecol Obstet Invest 69:184–189. https://doi.org/10.1159/000268051

Article  CAS  PubMed  Google Scholar 

Hameed AAAE, Shreif HE, Mowafy HE (2011) The role of continuing metformin therapy during pregnancy in the reduction of gestational diabetes and improving pregnancy outcomes in women with polycystic ovary syndrome. Middle East Fertility Society Journal 16:204–208

Article  Google Scholar 

Khattab S, Mohsen IA, Aboul Foutouh I et al (2011) Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. Gynecol Endocrinol 27:789–793. https://doi.org/10.3109/09513590.2010.540600

Article  CAS  PubMed  Google Scholar 

Ainuddin JA, Kazi S, Aftab S et al (2015) Metformin for preventing gestational diabetes in women with polycystic ovarian syndrome. J Coll Physicians Surg Pak 25:237–241

PubMed  Google Scholar 

Begum MR, Khanam NN, Quadir E et al (2009) Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome. J Obstet Gynaecol Res 35:282–286. https://doi.org/10.1111/j.1447-0756.2008.00876.x

Article  CAS  PubMed  Google Scholar 

Vanky E, Stridsklev S, Heimstad R et al (2010) Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study. J Clin Endocrinol Metab 95:E448-455. https://doi.org/10.1210/jc.2010-0853

Article  CAS  PubMed  Google Scholar 

Jamal A, Milani F, Al-Yasin A (2012) Evaluation of the effect of metformin and aspirin on utero placental circulation of pregnant women with PCOS. Iran J Reprod Med 10:265–270

CAS  PubMed  PubMed Central  Google Scholar 

Chiswick C, Reynolds RM, Denison F et al (2015) Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 3:778–786. https://doi.org/10.1016/S2213-8587(15)00219-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Syngelaki A, Nicolaides KH, Balani J et al (2016) Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus. N Engl J Med 374:434–443. https://doi.org/10.1056/NEJMoa1509819

Article  CAS  PubMed  Google Scholar 

Valdes E, Sepulveda-Martinez A, Candia P et al (2018) Metformin as a prophylactic treatment of gestational diabetes in pregnant patients with pregestational insulin resistance: A randomized study. J Obstet Gynaecol Res 44:81–86. https://doi.org/10.1111/jog.13477

Article  CAS  PubMed  Google Scholar 

Sales WB, Nascimento IBD, Dienstmann G et al (2018) Effectiveness of Metformin in the Prevention of Gestational Diabetes Mellitus in Obese Pregnant Women. Rev Bras Ginecol Obstet 40:180–187. https://doi.org/10.1055/s-0038-1642632

Article  PubMed  Google Scholar 

Brink HS, Alkemade M, van der Lely AJ et al (2018) Metformin in women at high risk of gestational diabetes mellitus. Diabetes Metab 44:300–302. https://doi.org/10.1016/j.diabet.2018.01.008

Article  CAS  PubMed  Google Scholar 

Lovvik TS, Carlsen SM, Salvesen O et al (2019) Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 7:256–266. https://doi.org/10.1016/S2213-8587(19)30002-6

Article  PubMed  Google Scholar 

Xu J (2019) Study on the effect of metformin treatment on pregnancy rate and incidence of gestational diabetes in overweight/obese patients with PCOS. Women’s Health Research 47:79

Google Scholar 

Xie M, Gao M, Meng X (2021) Effect of metformin on pregnancy rate and incidence of gestational diabetes mellitus in patients with PCOS. Journal of Practical Diabetology 17:122–123

Google Scholar 

Lundh A, Gotzsche PC (2008) Recommendations by Cochrane Review Groups for assessment of the risk of bias in studies. BMC Med Res Methodol 8:22. https://doi.org/10.1186/1471-2288-8-22

Article  PubMed  PubMed Central  Google Scholar 

Wells GA, Shea BJ, O'Connell D et al (2000) The Newcastle–Ottawa Scale (NOS) for Assessing the Quality of Non-Randomized Studies in Meta-Analysis

Higgins JP, Thompson SG, Deeks JJ et al (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560. https://doi.org/10.1136/bmj.327.7414.557

Article  PubMed  PubMed Central  Google Scholar 

Guo L, Ma J, Tang J et al (2019) Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis. J Diabetes Res 2019:9804708. https://doi.org/10.1155/2019/9804708

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balsells M, Garcia-Patterson A, Sola I et al (2015) Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. BMJ 350:h102. https://doi.org/10.1136/bmj.h102

Feng Y, Yang H (2017) Metformin - a potentially effective drug for gestational diabetes mellitus: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 30:1874–1881. https://doi.org/10.1080/14767058.2016.1228061

Article  CAS  PubMed  Google Scholar 

Rena G, Hardie DG, Pearson ER (2017) The mechanisms of action of metformin. Diabetologia 60:1577–1585. https://doi.org/10.1007/s00125-017-4342-z

Article  CAS  PubMed  PubMed Central 

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