Udani S, Lazich I, Bakris GL. Epidemiology of hypertensive kidney disease. Nat Rev Nephrol. 2011;7:11–21.
Elijovich F, Laffer CL, Sahinoz M, Pitzer A, Ferguson JF, Kirabo A. The gut microbiome, inflammation, and salt-sensitive hypertension. Curr Hypertens Rep. 2020;22:79.
Article CAS PubMed PubMed Central Google Scholar
Slagman MC, Kwakernaak AJ, Yazdani S, Laverman GD, van den Born J, Titze J, et al. Vascular endothelial growth factor C levels are modulated by dietary salt intake in proteinuric chronic kidney disease patients and in healthy subjects. Nephrol Dial Transpl. 2012;27:978–82.
Lu X, Crowley SD. Inflammation in salt-sensitive hypertension and renal damage. Curr Hypertens Rep. 2018;20:103.
Article PubMed PubMed Central Google Scholar
Liu ML, Song HX, Tian XX, Liu YX, Liu D, Hou ZW, et al. Recombinant cellular repressor of E1A-stimulated genes protects against renal fibrosis in dahl salt-sensitive rats. Am J Nephrol. 2020;51:401–10.
Article CAS PubMed Google Scholar
Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, et al. Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. Cardiovasc Res. 2019;115:776–87.
Article CAS PubMed Google Scholar
Zhang X, Liu L, Yuan X, Wei Y, Wei X. JMJD3 in the regulation of human diseases. Protein Cell. 2019;10:864–82.
Article CAS PubMed PubMed Central Google Scholar
Huang M, Wang Q, Long F, Di Y, Wang J, Zhun Zhu Y, et al. Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice. FASEB j. 2020;34:4107–19.
Article CAS PubMed Google Scholar
Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, et al. Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. J Exp Med. 2021;218:e20201839.
Article CAS PubMed PubMed Central Google Scholar
Long F, Wang Q, Yang D, Zhu M, Wang J, Zhu Y, et al. Targeting JMJD3 histone demethylase mediates cardiac fibrosis and cardiac function following myocardial infarction. Biochem Biophys Res Commun. 2020;528:671–77.
Article CAS PubMed Google Scholar
Lai J, Ge M, Shen S, Yang L, Jin T, Cao D, et al. Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation. Biochim Biophys Acta Mol Basis Dis. 2019;1865:2403–10.
Article CAS PubMed Google Scholar
Bergmann C, Brandt A, Merlevede B, Hallenberger L, Dees C, Wohlfahrt T, et al. The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis. Ann Rheum Dis. 2018;77:150–58.
Article CAS PubMed Google Scholar
Liang H, Liu B, Gao Y, Nie J, Feng S, Yu W, et al. Jmjd3/ IRF4 axis aggravates myeloid fibroblast activation and M2 macrophage to myofibroblast transition in renal fibrosis. Front Immunol. 2022;13:978262.
Article CAS PubMed PubMed Central Google Scholar
Wilde E, Aubdool AA, Thakore P, Baldissera L Jr, Alawi KM, Keeble J, et al. Tail-cuff technique and its influence on central blood pressure in the mouse. J Am Heart Assoc. 2017;6:e005204.
Article PubMed PubMed Central Google Scholar
Liang H, Zhang Z, Yan J, Wang Y, Hu Z, Mitch WE, et al. The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017;92:1433–43.
Article CAS PubMed PubMed Central Google Scholar
Chen M, Wen X, Gao Y, Liu B, Zhong C, Nie J, et al. IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury. Int Immunopharmacol. 2021;100:108142.
Article CAS PubMed Google Scholar
Liang H, Ma Z, Peng H, He L, Hu Z, Wang Y. CXCL16 deficiency attenuates renal injury and fibrosis in salt-sensitive hypertension. Sci Rep. 2016;6:28715.
Article CAS PubMed PubMed Central Google Scholar
Sun YB, Qu X, Caruana G, Li J. The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis. Differentiation. 2016;92:102–07.
Article CAS PubMed Google Scholar
Yan J, Zhang Z, Jia L, Wang Y. Role of bone marrow-derived fibroblasts in renal fibrosis. Front Physiol. 2016;7:61.
Article PubMed PubMed Central Google Scholar
Wei J, Xu Z, Yan X. The role of the macrophage-to-myofibroblast transition in renal fibrosis. Front Immunol. 2022;13:934377.
Article CAS PubMed PubMed Central Google Scholar
Wang YY, Jiang H, Pan J, Huang XR, Wang YC, Huang HF, et al. Macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury. J Am Soc Nephrol. 2017;28:2053–67.
Article CAS PubMed PubMed Central Google Scholar
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010;11:936–44.
Article CAS PubMed Google Scholar
Ming-Chin Lee K, Achuthan AA, De Souza DP, Lupancu TJ, Binger KJ, Lee MKS, et al. Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization. Cell Rep. 2022;39:110719.
Article CAS PubMed Google Scholar
Tang J, Liu N, Zhuang S. Role of epidermal growth factor receptor in acute and chronic kidney injury. Kidney Int. 2013;83:804–10.
Article CAS PubMed PubMed Central Google Scholar
Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol. 2011;7:684–96.
Article CAS PubMed PubMed Central Google Scholar
Djudjaj S, Boor P. Cellular and molecular mechanisms of kidney fibrosis. Mol Asp Med. 2019;65:16–36.
He C, Larson-Casey JL, Gu L, Ryan AJ, Murthy S, Carter AB. Cu,Zn-superoxide dismutase-mediated redox regulation of jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis. Am J Respir Cell Mol Biol. 2016;55:58–71.
Article CAS PubMed PubMed Central Google Scholar
Oh J, Matkovich SJ, Riek AE, Bindom SM, Shao JS, Head RD, et al. Macrophage secretion of miR-106b-5p causes renin-dependent hypertension. Nat Commun. 2020;11:4798.
Article CAS PubMed PubMed Central Google Scholar
Krämer S, Binder E, Loof T, Wang-Rosenke Y, Martini S, Khadzhynov D, et al. The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy. Am J Physiol Ren Physiol. 2009;297:F218–27.
Tang PM, Nikolic-Paterson DJ, Lan HY. Macrophages: versatile players in renal inflammation and fibrosis. Nat Rev Nephrol. 2019;15:144–58.
Sato Y, Yanagita M. Resident fibroblasts in the kidney: a major driver of fibrosis and inflammation. Inflamm Regen. 2017;37:17.
Article PubMed PubMed Central Google Scholar
Srivastava SP, Hedayat AF, Kanasaki K, Goodwin JE. microRNA crosstalk influences epithelial-to-mesenchymal, endothelial-to-mesenchymal, and macrophage-to-mesenchymal transitions in the kidney. Front Pharm. 2019;10:904.
Wang JJ, Wang X, Xian YE, Chen ZQ, Sun YP, Fu YW, et al. The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model. J Biol Chem. 2022;298:102017.
Article CAS PubMed PubMed Central Google Scholar
Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, et al. DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway. Mol Psychiatry. 2018;23:1410–20.
Article CAS PubMed Google Scholar
Wu W, Qin M, Jia W, Huang Z, Li Z, Yang D, et al. Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. Cell Mol Immunol. 2019;16:694–705.
Article CAS PubMed Google Scholar
Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214:199–210.
留言 (0)