Youssef AA, Raafat TA, Madney Y (2015) Child with acute methotrexate related neurotoxicity: can diffusion weighted MRI help?? Egypt J Radiol Nucl Med 46(4):1149–1153
Krull KR, Hardy KK, Kahalley LS, Schuitema I, Kesler SR (2018) Neurocognitive outcomes and interventions in long-term survivors of childhood cancer. J Clin Oncol 36(21):2181
Article CAS PubMed PubMed Central Google Scholar
Rijmenams I, Moechars D, Uyttebroeck A, Radwan A, Blommaert J, Deprez S, Sunaert S, Segers H et al (2021) Age-and intravenous methotrexate-associated leukoencephalopathy and its neurological impact in pediatric patients with lymphoblastic leukemia. Cancers 13(8):1939
Welbat JU, Naewla S, Pannangrong W, Sirichoat A, Aranarochana A, Wigmore PJBP (2020) Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat. Biochem Pharmacol 178:114083. https://doi.org/10.1016/j.bcp.2020.114083
Article CAS PubMed Google Scholar
Wen J, Patel C, Diglio F, Baker K, Marshall G, Li S, Cole PD (2022) Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate. Neuropharmacology 206:108939
Article CAS PubMed PubMed Central Google Scholar
Gibson EM, Nagaraja S, Ocampo A, Tam LT, Wood LS, Pallegar PN, Greene JJ, Geraghty AC et al (2019) Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment. Cell 176(1):43–55. https://doi.org/10.1016/j.cell.2018.10.049
Article CAS PubMed Google Scholar
Wadhwa M, Prabhakar A, Ray K, Roy K, Kumari P, Jha PK, Kishore K, Kumar S et al (2017) Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. J Neuroinflammation 14(1):1–18
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T et al (2019) Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment. Neuron 103(2):250–265
Article CAS PubMed PubMed Central Google Scholar
Seigers R, Timmermans J, van der Horn HJ, de Vries EF, Dierckx RA, Visser L, Schagen SB, van Dam FS et al (2010) Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behav Brain Res 207(2):265–272
Article CAS PubMed Google Scholar
Lee EC, Hong D-Y, Lee D-H, Park S-W, Lee JY, Jeong JH, Kim E-Y, Chung H-M et al (2022) Inflammation and rho-associated protein kinase-induced brain changes in vascular dementia. Biomedicines 10(2):446
Article CAS PubMed PubMed Central Google Scholar
Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, Montine TJ, Herskowitz JH (2016) Rho-associated protein kinase 1 (ROCK 1) is increased in Alzheimer’s disease and ROCK 1 depletion reduces amyloid-β levels in brain. J Neurochem 138(4):525–531
Article CAS PubMed PubMed Central Google Scholar
Koch JC, Tatenhorst L, Roser A-E, Saal K-A, Tönges L, Lingor P (2018) ROCK inhibition in models of neurodegeneration and its potential for clinical translation. Pharmacol Ther 189:1–21
Article CAS PubMed Google Scholar
Borrajo A, Rodriguez-Perez AI, Diaz-Ruiz C, Guerra MJ, Labandeira-Garcia JL (2014) Microglial TNF-α mediates enhancement of dopaminergic degeneration by brain angiotensin. Glia 62(1):145–157
Barcia C, Ros CM, Annese V, Carrillo-de Sauvage MA, Ros-Bernal F, Gómez A, Yuste JE, Campuzano CM et al (2012) ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo. Sci Rep 2(1):1–13
Ding J, Li QY, Wang X, Sun CH, Lu CZ, Xiao BG (2010) Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice. J Neurochem 114(6):1619–1629
Article CAS PubMed Google Scholar
Hensel N, Rademacher S, Claus P (2015) Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front Neurosci 9:198
Article PubMed PubMed Central Google Scholar
Yang S, Wang G, Ma ZF, Lq Q, Zhai Yj YuZL, Xue M, Zhang Yh, Wan Z (2020) Dietary advanced glycation end products–induced cognitive impairment in aged ICR mice: protective role of quercetin. Mol Nutr Food Res 64(3):1901019
Li X, Wang S-W, Li X-L, Yu F-Y, Cong H-M (2020) Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression. Inflamm Res 69(9):897–910
Article CAS PubMed Google Scholar
Sharma P, Sharma S, Singh D (2020) Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus. Nutr Neurosci 23(2):118–127
Article CAS PubMed Google Scholar
Han J-Y, Ahn S-Y, Kim C-S, Yoo S-K, Kim S-K, Kim H-C, Hong JT, Oh K-W (2012) Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects. Biol Pharm Bull 35(9):1440–1446
Article CAS PubMed Google Scholar
Dourado NS, Souza CdS, De Almeida MMA, Bispo da Silva A, Dos Santos BL, Silva VDA, De Assis AM, da Silva JS et al (2020) Neuroimmunomodulatory and neuroprotective effects of the flavonoid apigenin in in vitro models of neuroinflammation associated with Alzheimer’s disease. Front Aging Neurosci 12:119
Article CAS PubMed PubMed Central Google Scholar
Sirichoat A, Krutsri S, Suwannakot K, Aranarochana A, Chaisawang P, Pannangrong W, Wigmore P, Welbat JU (2019) Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model. Biochem Pharmacol 163:225–233
Article CAS PubMed Google Scholar
Sritawan N, Prajit R, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU (2020) Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. Biomed Pharmacother 131:110651
Article CAS PubMed Google Scholar
Naewla S, Sirichoat A, Pannangrong W, Chaisawang P, Wigmore P, Welbat JU (2019) Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats. Nutrients 11(4):936
Article CAS PubMed PubMed Central Google Scholar
Fayez AM, Mansour DF, Saleh DO (2021) Progression of hepatic encephalopathy induced by bile duct ligation versus thioacetamide in rats: regulatory role of apigenin. J Appl Pharm Sci 11(12):158–168
Malik S, Suchal K, Khan SI, Bhatia J, Kishore K, Dinda AK, Arya DS (2017) Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. Am J Physiol Renal Physiol 313(2):F414–F422
Article CAS PubMed Google Scholar
Antunes M, Biala G (2012) The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process 13(2):93–110
Article CAS PubMed Google Scholar
Broadbent NJ, Squire LR, Clark RE (2004) Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci 101(40):14515–14520
Article CAS PubMed PubMed Central Google Scholar
Gehring TV, Luksys G, Sandi C, Vasilaki E (2015) Detailed classification of swimming paths in the Morris water maze: multiple strategies within one trial. Sci Rep 5(1):1–15
Motawi TK, El-Maraghy SA, Sabry D, Nady OM, Senousy MA (2022) Cromolyn chitosan nanoparticles reverse the DNA methylation of RASSF1A and p16 genes and mitigate DNMT1 and METTL3 expression in breast cancer cell line and tumor xenograft model in mice. Chem Biol Interact 365:110094. https://doi.org/10.1016/j.cbi.2022.110094
Article CAS PubMed Google Scholar
Culling CFA (2013) Handbook of histopathological and histochemical techniques: including museum techniques. Butterworth-Heinemann
Abbas H, Gad HA, Khattab MA, Mansour M (2021) The tragedy of Alzheimer’s disease: towards better management via resveratrol-loaded oral bilosomes. Pharmaceutics 13(10):1635
Article CAS PubMed PubMed Central Google Scholar
Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9(7):671–675. https://doi.org/10.1038/nmeth.2089
Article CAS PubMed PubMed Central Google Scholar
Desale SE, Chinnathambi S (2021) α-Linolenic acid induces clearance of tau seeds via actin-remodeling in microglia. Mol Biomed 2(1):1–14
Chen Y-C, Sheen J-M, Wang S-C, Hsu M-H, Hsiao C-C, Chang K-A, Huang L-T (2021) Methotrexate neurotoxicity is related to epigenetic modification of the myelination process. Int J Mol Sci 22(13):6718
Article CAS PubMed PubMed Central Google Scholar
Vazi E, Holanda F, Santos N, Cardoso C, Martins M, Bondan E (2021) Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Res Vet Sci 138:39–48
Article CAS PubMed Google Scholar
Gibson EM, Monje M (2021) Microglia in cancer therapy-related cognitive impairment. Trends Neurosci 44(6):441–451
留言 (0)