Leggett J. Approach to fever or suspected infection in the normal host. In: Goldman L, Schafer A, editors. Goldman’s Cecil Medicine, vol. 2. Philadelphia: Elsevier; 2020.

Google Scholar 

Steele GM, Franco-Paredes C, Chastain DB. Noninfectious causes of fever in adults. Nurse Pract. 2018;43:38–44.

Article  PubMed  Google Scholar 

Ogoina D. Fever, fever patterns and diseases called ’fever’-a review. J Infect Public Health. 2011;4:108–24.

Article  PubMed  Google Scholar 

Nawar EW, Niska RW, Xu J. National hospital ambulatory medical care survey: 2005 emergency department summary. Adv Data. 2007;386:1–32.

Google Scholar 

Feikin DR, Olack B, Bigogo GM, Audi A, Cosmas L, Aura B, et al. The burden of common infectious disease syndromes at the clinic and household level from population-based surveillance in rural and urban Kenya. PLoS ONE. 2011;6: e16085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crump JA, Kirk MD. Estimating the burden of febrile illnesses. PLoS Negl Trop Dis. 2015;9: e0004040.

Article  PubMed  PubMed Central  Google Scholar 

D’Acremont V, Bosman A. WHO informal consultation on fever management in peripheral health care settings: a global review of evidence and practice. Geneva: World Health Organization; 2013.

Google Scholar 

Archibald LK, den Dulk MO, Pallangyo KJ, Reller LB. Fatal Mycobacterium tuberculosis bloodstream infections in febrile hospitalized adults in Dar es Salaam, Tanzania. Clin Infect Dis. 1998;26:290–6.

Article  CAS  PubMed  Google Scholar 

Gordon MA, Walsh AL, Chaponda M, Soko D, Mbvwinji M, Molyneux ME, et al. Bacteraemia and mortality among adult medical admissions in Malawi—predominance of non-typhi salmonellae and Streptococcus pneumoniae. J Infect. 2001;42:44–9.

Article  CAS  PubMed  Google Scholar 

Chheng K, Carter MJ, Emary K, Chanpheaktra N, Moore CE, Stoesser N, et al. A prospective study of the causes of febrile illness requiring hospitalization in children in Cambodia. PLoS ONE. 2013;8: e60634.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maze MJ, Bassat Q, Feasey NA, Mandomando I, Musicha P, Crump JA. The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management. Clin Microbiol Infect. 2018;24:808–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson ML, Manabe YC. Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape. Am J Trop Med Hyg. 2017;96:1285–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schroeder LF, Amukele T. Medical laboratories in sub-Saharan Africa that meet international quality standards. Am J Clin Pathol. 2014;141:791–5.

Article  PubMed  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6: e1000097.

Article  PubMed  PubMed Central  Google Scholar 

Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine (Baltimore). 1961;40:1–30.

Article  CAS  PubMed  Google Scholar 

African Union. Member states. https://au.int/en/member_states/countryprofiles2. Accessed 22 March 2023.

Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, et al. Systematic reviews of etiology and risk. In: Aromataris E, Munn Z, editors., et al., JBI manual for evidence synthesis, vol. 5. Adelaide: JBI; 2020.

Google Scholar 

Nyaga VN, Arbyn M, Aerts M. Metaprop: a Stata command to perform meta-analysis of binomial data. Arch Public Health. 2014;72:39.

Article  PubMed  PubMed Central  Google Scholar 

Woodruff PW, Morrill JC, Burans JP, Hyams KC, Woody JN. A study of viral and rickettsial exposure and causes of fever in Juba, southern Sudan. Trans R Soc Trop Med Hyg. 1988;82:761–6.

Article  CAS  PubMed  Google Scholar 

Ssali FN, Kamya MR, Wabwire-Mangen F, Kasasa S, Joloba M, Williams D, et al. A prospective study of community-acquired bloodstream infections among febrile adults admitted to Mulago Hospital in Kampala, Uganda. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19:484–9.

Article  CAS  PubMed  Google Scholar 

Crump JA, Ramadhani HO, Morrissey AB, Saganda W, Mwako MS, Yang LY, et al. Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected adults and adolescents in northern Tanzania. Clin Infect Dis. 2011;52:341–8.

Article  PubMed  PubMed Central  Google Scholar 

Mease LE, Coldren RL, Musila LA, Prosser T, Ogolla F, Ofula VO, et al. Seroprevalence and distribution of arboviral infections among rural Kenyan adults: a cross-sectional study. Virol J. 2011;8:371.

Article  PubMed  PubMed Central  Google Scholar 

Prabhu M, Nicholson WL, Roche AJ, Kersh GJ, Fitzpatrick KA, Oliver LD, et al. Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania. Clin Infect Dis. 2011;53:e8-15.

Article  PubMed  PubMed Central  Google Scholar 

Zenebe T, Kannan S, Yilma D, Beyene G. Invasive bacterial pathogens and their antibiotic susceptibility patterns in Jimma University Specialized Hospital, Jimma, southwest Ethiopia. Ethiop J Health Sci. 2011;21:1–8.

Article  PubMed  PubMed Central  Google Scholar 

Hertz JT, Munishi OM, Ooi EE, Howe S, Lim WY, Chow A, et al. Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg. 2012;86:171–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meremo AJ, Kidenya BR, Mshana SE, Kabangila R, Kataraihya JB. High prevalence of tuberculosis among adults with fever admitted at a tertiary hospital in north-western Tanzania. Tanzan J Health Res. 2012;14:183–8.

PubMed  Google Scholar 

Meremo A, Mshana SE, Kidenya BR, Kabangila R, Peck R, Kataraihya JB. High prevalence of non-typhoid salmonella bacteraemia among febrile HIV adult patients admitted at a tertiary hospital, north-western Tanzania. Int Arch Med. 2012;5:28.

Article  PubMed  PubMed Central  Google Scholar 

Nadjm B, Mtove G, Amos B, Walker NF, Diefendal H, Reyburn H, et al. Severe febrile illness in adult hospital admissions in Tanzania: a prospective study in an area of high malaria transmission. Trans R Soc Trop Med Hyg. 2012;106:688–95.

Article  PubMed  Google Scholar 

Crump JA, Morrissey AB, Nicholson WL, Massung RF, Stoddard RA, Galloway RL, et al. Etiology of severe non-malaria febrile illness in northern Tanzania: a prospective cohort study. PLoS Negl Trop Dis. 2013;7: e2324.

Article  PubMed  PubMed Central  Google Scholar 

Moon AM, Biggs HM, Rubach MP, Crump JA, Maro VP, Saganda W, et al. Evaluation of in-hospital management for febrile illness in northern Tanzania before and after 2010 World Health Organization guidelines for the treatment of malaria. PLoS ONE. 2014;9: e89814.

Article  PubMed  PubMed Central  Google Scholar 

Feleke SM, Animut A, Belay M. Prevalence of malaria among acute febrile patients clinically suspected of having malaria in the Zeway Health Center, Ethiopia. Jpn J Infect Dis. 2015;68:55–9.

Article  PubMed  Google Scholar 

Ochieng C, Ahenda P, Vittor AY, Nyoka R, Gikunju S, Wachira C, et al. Seroprevalence of infections with dengue, Rift Valley fever and chikungunya viruses in Kenya, 2007. PLoS ONE. 2015;10: e0132645.

Article  PubMed  PubMed Central  Google Scholar 

Hercik C, Cosmas L, Mogeni OD, Wamola N, Kohi W, Omballa V, et al. A diagnostic and epidemiologic investigation of acute febrile illness (AFI) in Kilombero, Tanzania. PLoS ONE. 2017;12: e0189712.

Article  PubMed  PubMed Central  Google Scholar 

Boillat-Blanco N, Mbarack Z, Samaka J, Mlaganile T, Mamin A, Genton B, et al. Prognostic value of quickSOFA as a predictor of 28-day mortality among febrile adult patients presenting to emergency departments in Dar es Salaam, Tanzania. PLoS ONE. 2018;13: e0197982.

Article  PubMed  PubMed Central  Google Scholar 

Guillebaud J, Bernardson B, Randriambolamanantsoa TH, Randrianasolo L, Randriamampionona JL, Marino CA, et al. Study on causes of fever in primary healthcare center uncovers pathogens of public health concern in Madagascar. PLoS Negl Trop Dis. 2018;12: e0006642.

Article  PubMed  PubMed Central  Google Scholar 

Hercik C, Cosmas L, Mogeni OD, Wamola N, Kohi W, Houpt E, et al. A combined syndromic approach to examine viral, bacterial, and parasitic agents among febrile patients: a pilot study in Kilombero, Tanzania. Am J Trop Med Hyg. 2018;98:625–32.

Article  CAS  PubMed  Google Scholar 

Zerfu B, Medhin G, Mamo G, Getahun G, Tschopp R, Legesse M. Community-based prevalence of typhoid fever, typhus, brucellosis and malaria among symptomatic individuals in Afar Region, Ethiopia. PLoS Negl Trop Dis. 2018;12: e0006749.

Article  PubMed  PubMed Central  Google Scholar 

Ali MA, James OC, Mohamed AA, Joachim A, Mubi M, Omodior O. Etiologic agents of fever of unknown origin among patients attending Mnazi Mmoja Hospital, Zanzibar. J Community Health. 2020;45:1073–80.

Article  PubMed  Google Scholar 

Budodo RM, Horumpende PG, Mkumbaye SI, Mmbaga BT, Mwakapuja RS, Chilongola JO. Serological evidence of exposure to Rift Valley, dengue and chikungunya viruses among agropastoral communities in Manyara and Morogoro regions in Tanzania: a community survey. PLo