Effects of duration of exposure, co-supplementation with iron and Nippostrongylus brasiliensis infection on accumulation of trichloroacetic acid-insoluble copper in rats given molybdate in drinking water

Thiolation can convert molybdate (MoO4) into a series of thiomolybdates (MoSxO4-x) in the rumen, terminating in tetrathiomolybdate (MoS4), a potent antagonist of copper absorption and, if absorbed, donor of reactive sulphide in tissues. Since entry of thiomolybdates (TM) into the circulation increases trichloroacetic acid-insoluble copper (TCAI Cu) concentrations in plasma [[1], [2], [3]], induction of TCAI Cu in plasma of rats given molybdate (MoO4) in drinking water would support the hypothesis that rats, as well as ruminants, can thiolate MoO4 [4,5]. Such evidence was extracted from two experiments with rats, one investigating the effects of MoO4 exposure on tissue biochemistry, the other the parasitological responses to co-supplementation with iron (Fe), during infection with Nippostrongylus brasiliensis. Co-supplementation with Fe has not been studied in non-ruminants but in cattle, copper deficiency is not exacerbated when dietary Fe and MoO4 are given together [3].

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