A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reduces Purkinje cell death in a mouse model of ARSACS
Keywords
Ataxia
Autosomal-recessive spastic ataxia of the Charlevoix-Saguenay
ARSACS
MitoQ
Mitochondria
Purkinje cell
Cerebellum
Cerebellar nuclei
Mouse model of disease
AbbreviationsACSF
artificial cerebrospinal fluid
ARSACS
Autosomal-recessive spastic ataxia of the Charlevoix-Saguenay
CV
coefficient of variation
MitoQ
mitochondrial-targeted antioxidant ubiquinone or mitoquinone mesylate
SCA
spinocerebellar ataxia
SOD2
superoxide dismutase 2
Data availability
Data will be made available on request.
© 2023 Published by Elsevier Inc.
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