Alcazer, V. et al. Neoepitopes-based vaccines: challenges and perspectives. Eur. J. Cancer 108, 55–60 (2019).
Blass, E. et al. Advances in the development of personalized neoantigen-based therapeutic cancer vaccines. Nat. Rev. Clin. Oncol. 18, 215–229 (2021).
Yarchoan, M. et al. Targeting neoantigens to augment antitumour immunity. Nat. Rev. Cancer 17, 209–222 (2017).
Article CAS PubMed PubMed Central Google Scholar
Malonis, R. J., Lai, J. R. & Vergnolle, O. Peptide-based vaccines: current progress and future challenges. Chem. Rev. 120, 3210–3229 (2020).
Article CAS PubMed Google Scholar
Sellars, M. C., Wu, C. J. & Fritsch, E. F. Cancer vaccines: building a bridge over troubled waters. Cell 185, 2770–2788 (2022).
Article CAS PubMed Google Scholar
Sharma, P. et al. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat. Rev. Cancer 11, 805–812 (2011).
Article CAS PubMed PubMed Central Google Scholar
Restifo, N. P. et al. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat. Rev. Immunol. 12, 269–281 (2012).
Article CAS PubMed PubMed Central Google Scholar
Daniel, S. At the bench: engineering the next generation of cancer vaccines. J. Leukoc. Biol. 108, 1435–1453 (2020).
Bijker, M. S. et al. Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation. Eur. J. Immunol. 38, 1033–1042 (2008).
Article CAS PubMed Google Scholar
Su, M. W. et al. Cognate peptide-induced destruction of CD8+ cytotoxic lymphocytes is due to fratricide. J. Immunol. 151, 658–667 (1993).
Article CAS PubMed Google Scholar
Audiger, C. et al. The importance of dendritic cells in maintaining immune tolerance. J. Immunol. 198, 2223–2231 (2017).
Article CAS PubMed Google Scholar
Zou, W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5, 263–274 (2005).
Article CAS PubMed Google Scholar
Nicolas, A. et al. The clinical role of the TME in solid cancer. Br. J. Cancer 120, 45–53 (2019).
Altorki, N. K. et al. The lung microenvironment: an important regulator of tumour growth and metastasis. Nat. Rev. Cancer 19, 9–31 (2019).
Article CAS PubMed PubMed Central Google Scholar
Twumasi-Boateng, K. et al. Oncolytic viruses as engineering platforms for combination immunotherapy. Nat. Rev. Cancer 18, 419–432 (2018).
Article CAS PubMed Google Scholar
Dock, G. The influence of complicating diseases upon leukaemia. Am. J. Med. Sci. 127, 563 (1904).
Gerlach, T. et al. Recombinant influenza A viruses as vaccine vectors. Expert Rev. Vaccines 18, 379–392 (2019).
Article CAS PubMed Google Scholar
Sellers, S. A. et al. The hidden burden of influenza: a review of the extra- pulmonary complications of influenza infection. Influenza Other Respir. Viruses 11, 372–393 (2017).
Article PubMed PubMed Central Google Scholar
Kwong, J. C. et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N. Engl. J. Med. 378, 345–353 (2018).
Si, L. et al. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science 354, 1170–1173 (2015).
Miller, C. L. et al. Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression. Cell Chem. Biol. 29, 451–462 (2022).
Article CAS PubMed Google Scholar
Giavazzi, R. et al. Syngeneic murine metastasis models: B16 melanoma. Methods Mol. Biol. 1070, 131–140 (2014).
Article CAS PubMed Google Scholar
Pump, K. K. Morphology of the acinus of the human lung. Dis. Chest 66, 126–134 (1969).
Newman, J. H. et al. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc. Natl Acad. Sci. USA 117, 1119–1128 (2020).
Article CAS PubMed Google Scholar
Zhao, H. et al. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct. Target. Ther. 6, 263 (2021).
Article CAS PubMed PubMed Central Google Scholar
Helft, J. et al. Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J. Clin. Invest. 122, 4037–4047 (2012).
Article CAS PubMed PubMed Central Google Scholar
Ho, A. W. S. et al. Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells. J. Immunol. 187, 6011–6021 (2011).
Article CAS PubMed Google Scholar
Benci, J. L. et al. Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade. Cell 167, 1540–1554 (2016).
Article CAS PubMed PubMed Central Google Scholar
June, C. H. & Sadelain, M. Chimeric antigen receptor therapy. N. Engl. J. Med. 379, 64–73 (2018).
Article CAS PubMed PubMed Central Google Scholar
Marofi, F. et al. CAR T cells in solid tumors: challenges and opportunities. Stem Cell Res. Ther. 12, 81 (2021).
Ripley, R. T. & Rusch, V. W. Lung metastases. In Abeloff’s Clinical Oncology 5th edn (eds Niederhuber, J. E. et al.) 64–777 (Saunders, 2013).
Ferrucci, P. F. et al. Talimogene laherparepvec (T-VEC): an intralesional cancer immunotherapy for advanced melanoma. Cancers (Basel). 13, 1383 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bertrand, A. et al. Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med. 13, 211 (2015).
Article PubMed PubMed Central Google Scholar
Weber, J. Review: anti-CTLA-4 antibody ipilimumab: case studies of clinical response and immune-related adverse events. Oncologist. 12, 864–872 (2007).
Article CAS PubMed Google Scholar
Hamilton, J. R. et al. A recombinant antibody-expressing influenza virus delays tumor growth in a mouse model. Cell Rep. 22, 1–7 (2018).
Article CAS PubMed Google Scholar
Wandzik, J. M. et al. A structure-based model for the complete transcription cycle of influenza polymerase. Cell 181, 877–893 (2020).
Article CAS PubMed Google Scholar
Jorba, N. et al. Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog. 5, e1000462 (2009).
Article PubMed PubMed Central Google Scholar
Vreede, F. T. et al. Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. J Virol. 78, 9568–9572 (2004).
留言 (0)