Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, et al. Prevalence and severity of food allergies among US adults. JAMA Netw Open. 2019;2:e185630.

Article  PubMed  PubMed Central  Google Scholar 

Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124:1549–55.

Article  PubMed  Google Scholar 

Burks AW. Peanut allergy. Lancet. 2008;371:1538–46.

Article  CAS  PubMed  Google Scholar 

Investigators PGoC, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, et al. AR101 oral immunotherapy for peanut allergy. N Engl J Med. 2018;379:1991–2001.

Avery NJ, King RM, Knight S, Hourihane JO. Assessment of quality of life in children with peanut allergy. Pediatr Allergy Immunol. 2003;14:378–82.

Article  PubMed  Google Scholar 

Tordesillas L, Berin MC. Mechanisms of oral tolerance. Clin Rev Allergy Immunol. 2018;55:107–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smeekens JM, Kulis MD. Evolution of immune responses in food immunotherapy. Immunol Allergy Clin North Am. 2020;40:87–95.

Article  PubMed  Google Scholar 

Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102:e6.

Article  CAS  PubMed  Google Scholar 

Lack G. Update on risk factors for food allergy. J Allergy Clin Immunol. 2012;129:1187–97.

Article  PubMed  Google Scholar 

Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372:803–13.

Article  PubMed  PubMed Central  Google Scholar 

Du Toit G, Sayre PH, Roberts G, Sever ML, Lawson K, Bahnson HT, et al. Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med. 2016;374:1435–43.

Article  PubMed  Google Scholar 

Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016;374:1733–43.

Article  CAS  PubMed  Google Scholar 

Sicherer SH, Sampson HA. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018;141:41–58.

Article  CAS  PubMed  Google Scholar 

Peters RL, Mavoa S, Koplin JJ. An overview of environmental risk factors for food allergy. Int J Environ Res Public Health. 2022;19.

Moran TP. Impact of the exposome on food allergy development. Curr Opin Allergy Clin Immunol. 2023;23:164–71.

Article  CAS  PubMed  Google Scholar 

Yu JE, Mallapaty A, Miller RL. It’s not just the food you eat: environmental factors in the development of food allergies. Environ Res. 2018;165:118–24.

Article  CAS  PubMed  Google Scholar 

Maciag MC, Sheehan WJ, Bartnikas LM, Lai PS, Petty CR, Filep S, et al. Detection of food allergens in school and home environments of elementary students. J Allergy Clin Immunol Pract. 2021;9:3735–43.

Article  PubMed  PubMed Central  Google Scholar 

Bertelsen RJ, Faeste CK, Granum B, Egaas E, London SJ, Carlsen KH, et al. Food allergens in mattress dust in Norwegian homes - a potentially important source of allergen exposure. Clin Exp Allergy. 2014;44:142–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brough HA, Makinson K, Penagos M, Maleki SJ, Cheng H, Douiri A, et al. Distribution of peanut protein in the home environment. J Allergy Clin Immunol. 2013;132:623–9.

Article  CAS  PubMed  Google Scholar 

Sheehan WJ, Brough HA, Makinson K, Petty CR, Lack G, Phipatanakul W. Distribution of peanut protein in school and home environments of inner-city children. J Allergy Clin Immunol. 2017;140:1724–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brough HA, Mills ENC, Richards K, Lack G, Johnson PE. Mass spectrometry confirmation that clinically important peanut protein allergens are present in household dust. Allergy. 2020;75:709–12.

Article  PubMed  Google Scholar 

Brough HA, Santos AF, Makinson K, Penagos M, Stephens AC, Douiri A, et al. Peanut protein in household dust is related to household peanut consumption and is biologically active. J Allergy Clin Immunol. 2013;132:630–8.

Article  CAS  PubMed  Google Scholar 

Brough HA, Liu AH, Sicherer S, Makinson K, Douiri A, Brown SJ, et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol. 2015;135:164–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trendelenburg V, Tschirner S, Niggemann B, Beyer K. Hen’s egg allergen in house and bed dust is significantly increased after hen’s egg consumption-a pilot study. Allergy. 2018;73:261–4.

Article  CAS  PubMed  Google Scholar 

Witteman AM, van Leeuwen J, van der Zee J, Aalberse RC. Food allergens in house dust. Int Arch Allergy Immunol. 1995;107:566–8.

Article  CAS  PubMed  Google Scholar 

Ng N, Lam D, Paulus P, Batzer G, Horner AA. House dust extracts have both TH2 adjuvant and tolerogenic activities. J Allergy Clin Immunol. 2006;117:1074–81.

Article  CAS  PubMed  Google Scholar 

Moran TP, Nakano K, Whitehead GS, Thomas SY, Cook DN, Nakano H. Inhaled house dust programs pulmonary dendritic cells to promote type 2 T-cell responses by an indirect mechanism. Am J Physiol Lung Cell Mol Physiol. 2015;309:L1208–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gough L, Sewell HF, Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen. Clin Exp Allergy. 2001;31:1594–8.

Article  CAS  PubMed  Google Scholar 

Boasen J, Chisholm D, Lebet L, Akira S, Horner AA. House dust extracts elicit Toll-like receptor-dependent dendritic cell responses. J Allergy Clin Immunol. 2005;116:185–91.

Article  CAS  PubMed  Google Scholar 

Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. Science. 2015;349:1106–10.

Article  CAS  PubMed  Google Scholar 

Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N Engl J Med. 2016;375:411–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hill DJ, Sporik R, Thorburn J, Hosking CS. The association of atopic dermatitis in infancy with immunoglobulin E food sensitization. J Pediatr. 2000;137:475–9.

Article  CAS  PubMed  Google Scholar 

Elias PM, Steinhoff M. “Outside-to-inside” (and now back to “outside”) pathogenic mechanisms in atopic dermatitis. J Invest Dermatol. 2008;128:1067–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brough HA, Kull I, Richards K, Hallner E, Söderhäll C, Douiri A, et al. Environmental peanut exposure increases the risk of peanut sensitization in high-risk children. Clin Exp Allergy. 2018;48:586–93.

Article  CAS  PubMed  Google Scholar 

Brough HA, Simpson A, Makinson K, Hankinson J, Brown S, Douiri A, et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol. 2014;134:867-75.e1.

Article  PubMed  PubMed Central  Google Scholar 

• Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, et al. Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol. 2019;144:494–503. Independent of eczema severity, Staphylococcus aureus colonization was associated with food allergy in LEAP participants.

Article  PubMed  Google Scholar 

Chan SM, Turcanu V, Stephens AC, Fox AT, Grieve AP, Lack G. Cutaneous lymphocyte antigen and α4β7 T-lymphocyte responses are associated with peanut allergy and tolerance in children. Allergy. 2012;67:336–42.

Article  CAS  PubMed  Google Scholar 

DeLong JH, Simpson KH, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1-reactive T cells in individuals with peanut allergy. J Allergy Clin Immunol. 2011;127:1211-8.e3.

Article  CAS  PubMed  PubMed Central