Locksley RM. Asthma and allergic inflammation. Cell. 2010;140:777–783.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med. 2012;18:684–692.

Article  CAS  PubMed  Google Scholar 

Roan F, Obata-Ninomiya K, Ziegler SF. Epithelial cell-derived cytokines: more than just signaling the alarm. J Clin Investig. 2019;129:1441–1451.

Article  PubMed  PubMed Central  Google Scholar 

Liew FY, Girard JP, Turnquist HR. Interleukin-33 in health and disease. Nat Rev Immunol. 2016;16:676–689.

Article  CAS  PubMed  Google Scholar 

Molofsky AB, Savage AK, Locksley RM. Interleukin-33 in tissue homeostasis, injury, and inflammation. Immunity. 2015;42:1005–1019.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drake LY, Kita H. IL-33: biological properties, functions, and roles in airway disease. Immunol Rev. 2017;278:173–184.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De la Fuente M, MacDonald TT, Hermoso MA. The IL-33/ST2 axis: role in health and disease. Cytokine Growth Factor Rev. 2015;26:615–623.

Article  PubMed  Google Scholar 

Martin NT, Martin MU. Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol. 2016;17:122–131.

Article  CAS  PubMed  Google Scholar 

Grotenboer NS, et al. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. J Allergy Clin Immunol. 2013;131:856–865.

Article  CAS  PubMed  Google Scholar 

Moffatt MF, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363:1211–1221.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Savenije OE, et al. Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. J Allergy Clin Immunol. 2014;134:170–177.

Article  CAS  PubMed  Google Scholar 

Backman JD, et al. Exome sequencing and analysis of 454,787 UK Biobank participants. Nature. 2021;599:628–634.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tjota MY, et al. IL-33-dependent induction of allergic lung inflammation by FcgammaRIII signaling. J Clin Invest. 2013;123:2287–2297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardman CS, Panova V, McKenzie AN. IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation. Eur J Immunol. 2013;43:488–498.

Article  CAS  PubMed  Google Scholar 

Hsu CL, Neilsen CV, Bryce PJ. IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS ONE. 2010;5:e11944.

Article  PubMed  PubMed Central  Google Scholar 

Bessa J, et al. Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation. J Autoimmun. 2014;55:33–41.

Article  CAS  PubMed  Google Scholar 

Luthi AU, et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity. 2009;31:84–98.

Article  CAS  PubMed  Google Scholar 

Cayrol C, Girard JP. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA. 2009;106:9021–9026.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen ES, et al. Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation. Nat Commun. 2015;6:8327.

Article  CAS  PubMed  Google Scholar 

Hayakawa H, et al. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem. 2007;282:26369–26380.

Article  CAS  PubMed  Google Scholar 

Tao LQ, et al. Deubiquitination and stabilization of IL-33 by USP21. Int J Clin Exp Pathol. 2014;7:4930–4937.

PubMed  PubMed Central  Google Scholar 

Ni Y, et al. The deubiquitinase USP17 regulates the stability and nuclear function of IL-33. Int J Mol Sci. 2015;16:27956–27966.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, et al. MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness. Signal Transduct Target Ther. 2021;6:321.

Article  PubMed  PubMed Central  Google Scholar 

Ueland PM, et al. Inflammation, vitamin B6 and related pathways. Mol Asp Med. 2017;53:10–27.

Article  CAS  Google Scholar 

Reynolds RD, Natta CL. Depressed plasma pyridoxal phosphate concentrations in adult asthmatics. Am J Clin Nutr. 1985;41:684-8.

Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr. 2010;64:1007–1013.

Article  CAS  PubMed  Google Scholar 

Poyurovsky MV, et al. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J. 2007;26:90–101.

Article  CAS  PubMed  Google Scholar 

Nag S, et al. The MDM2-p53 pathway revisited. J Biomed Res. 2013;27:254–271.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Monge J, et al. MDM2 regulates RB levels during genotoxic stress. EMBO Rep. 2021;22:e50615.

Article  CAS  PubMed  Google Scholar 

Yang JY, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol. 2008;10:138–148.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang A, et al. Mouse double minute 2 homolog-mediated ubiquitination facilitates forkhead box P3 stability and positively modulates human regulatory T cell function. Front Immunol. 2020;11:1087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi YM, et al. Mdm2 is required for HDAC3 monoubiquitination and stability. Biochem Biophys Res Commun. 2019;517:353–358.

Article  CAS  PubMed  Google Scholar 

Alwarith J, et al. The role of nutrition in asthma prevention and treatment. Nutr Rev. 2020;78:928–938.

Article  PubMed  PubMed Central  Google Scholar 

Talaei M, Hughes DA, Mahmoud O, et al. Dietary intake of vitamin A, lung function and incident asthma in childhood. Eur Respir J. 2021;58:2004407.

Majak P, et al. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol. 2011;127:1294–1296.

Article  PubMed  Google Scholar 

Jolliffe DA, et al. Vitamin D metabolism is dysregulated in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2020;202:371–382.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Milan SJ, Hart A, Wilkinson M. Vitamin C for asthma and exercise-induced bronchoconstriction. Cochrane Database Syst Rev. 2013;2013:CD010391.

Qian B, et al. Effects of vitamin B6 deficiency on the composition and functional potential of T cell populations. J Immunol Res. 2017;2017:2197975.

Article  PubMed  PubMed Central  Google Scholar 

Agoro R, et al. IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016;46:2531–2541.

Article  CAS  PubMed  Google Scholar 

Uchida M, et al. Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium. Allergy. 2017;72:1521–1531.

Article  CAS  PubMed  Google Scholar 

Parra M, Stahl S, Hellmann H. Vitamin B(6) and its role in cell metabolism and physiology. Cells. 2018;7:84.

Kumar V, et al. Pyridoxal kinase: A vitamin B6 salvage pathway enzyme from Leishmania donovani. Int J Biol Macromol. 2018;119:320–334.

Article