Tolerability and tropism of recombinant adeno-associated virus vectors in the African green monkey (Chlorocebus sabaeus) anterior chamber

Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96:614–8.

Article  PubMed  Google Scholar 

Liu J, Saghizadeh M, Tuli SS, Kramerov AA, Lewin AS, Bloom DC, et al. Different tropism of adenoviruses and adeno-associated viruses to corneal cells: implications for corneal gene therapy. Mol Vision. 2008;14:2087–96.

CAS  Google Scholar 

Morgan JT, Murphy CJ, Russell P. What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease. Exp Eye Res. 2013;115:1–12.

Article  CAS  PubMed  Google Scholar 

Vranka JA, Kelley MJ, Acott TS, Keller KE. Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma. Exp Eye Res. Academic Press; 2015;133:112–25.

Hao XD, Gao H, Xu WH, Shan C, Liu Y, Zhou ZX, et al. Systematically Displaying the Pathogenesis of Keratoconus via Multi-Level Related Gene Enrichment-Based Review. Front Med. 2022;8:770138.

Article  Google Scholar 

Kay CN, Ryals RC, Aslanidi GV, Min SH, Ruan Q, Sun J, et al. Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors. PLoS ONE. 2013;8:e62097.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reid CA, Ertel KJ, Lipinski DM. Improvement of photoreceptor targeting via intravitreal delivery in mouse and human retina using combinatory rAAV2 capsid mutant vectors. Investig Ophthalmol Vis Sci. 2017;58:6429–39.

Article  CAS  Google Scholar 

Bogner B, Boye SL, Min SH, Peterson JJ, Ruan Q, Zhang Z, et al. Capsid mutated adeno-associated virus delivered to the anterior chamber results in efficient transduction of trabecular meshwork in mouse and rat. PLoS ONE. 2015;10:1–16.

Article  Google Scholar 

Mohan RR, Schultz GS, Hong JW, Mohan RR, Wilson SE. Gene transfer into rabbit keratocytes using AAV and lipid-mediated plasmid DNA vectors with a lamellar flap for stromal access. Exp Eye Res. 2003;76:373–83.

Article  CAS  PubMed  Google Scholar 

Hippert C, Ibanes S, Serratrice N, Court F, Malecaze F. Corneal Transduction by Intra-Stromal Injection of AAV Vectors In Vivo in the Mouse and Ex Vivo in Human Explants. PLoS ONE. 2012;7:35318.

Article  Google Scholar 

Rodriguez-Estevez L, Asokan P, Borrás T. Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristics. Gene Ther. 2020;27:127–42.

Article  CAS  PubMed  Google Scholar 

Buie LKK, Rasmussen CA, Porterfield EC, Ramgolam VS, Choi VW, Markovic-Plese S, et al. Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys. Investig Ophthalmol Vis Sci. 2010;51:236–48.

Article  Google Scholar 

Lee SH, Sim KS, Kim CY, Park TK. Transduction Pattern of AAVs in the Trabecular Meshwork and Anterior-Segment Structures in a Rat Model of Ocular Hypertension. Mol Ther Methods Clin Dev. 2019;14:197–205.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogner B, Boye SL, Min SH, Peterson JJ, Ruan Q, Zhang Z, et al. Capsid mutated adeno-associated virus delivered to the anterior chamber results in efficient transduction of trabecular meshwork in mouse and rat. PLoS ONE. 2015;10:e0128759.

Article  PubMed  PubMed Central  Google Scholar 

Dore KM. Vervets in the Caribbean. The International Encyclopedia of Primatology: John Wiley & Sons, Inc.; 2017:1–3.

Goody R, Hu W, Whittaker S, Henry S, Brookes R, Struharik M, et al. Definition of Normal Ophthalmic Measures in the African Green Monkey. Investig Ophthalmol Visual Sci: ARVO Meeting Abstract. 2013;54:14–6382.

Reid CA, Lipinski DM. Small and Micro-Scale Recombinant Adeno-Associated Virus Production and Purification for Ocular Gene Therapy Applications. Methods Mol Biol. 2018;1715:19–31.

Zolotukhin S. Production of recombinant adeno-associated virus vectors. Hum Gene Ther. 2005;16:551–7.

Article  CAS  PubMed  Google Scholar 

Piedra J, Ontiveros M, Miravet S, Penalva C, Monfar M, Chillon M. Development of a Rapid, Robust, and Universal PicoGreen-Based Method to Titer Adeno-Associated Vectors. Hum Gene Ther Methods. 2015;26:35–42.

Article  CAS  PubMed  Google Scholar 

Corey TM, Woodley VV, O’connor M, Connolly E, Doyle S, Shrader S, et al. Evaluation of the Dose-Dependent Inflammatory Response and No-Observable Adverse Effect Level of Intravitreal Endotoxin in the African Green Monkey. Transl Vis Sci Technol. 2022;11:17.

Article  PubMed  PubMed Central  Google Scholar 

Hussein N, Ostler B, Gormus BJ, Wolf R, Walsh GP. Intraocular pressure changes and postural changes of intraocular pressure in experimentally induced Hansen’s disease of Rhesus, Mangabey, and African green monkeys. Br J Ophthalmol. 1990;74:647–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouskila J, Palmour RM, Bouchard JF, Ptito M. Retinal structure and function in monkeys with fetal alcohol exposure. Exp Eye Res. 2018;177:55–64.

Article  CAS  PubMed  Google Scholar 

Bouquet C, Vignal Clermont C, Galy A, Fitoussi S, Blouin L, Munk MR, et al. Immune Response and Intraocular Inflammation in Patients with Leber Hereditary Optic Neuropathy Treated with Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene: A Secondary Analysis of a Phase 1/2 Clinical Trial. JAMA Ophthalmol. 2019;137:399–406.

Article  PubMed  PubMed Central  Google Scholar 

Chan YK, Dick AD, Hall SM, Langmann T, Scribner CL, Mansfield BC. Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness. Trans Vis Sci Tech. 2021;10:3.

Article  Google Scholar 

Ansari AM, Ahmed AK, Matsangos AE, Lay F, Born LJ, Marti G, et al. Cellular GFP Toxicity and Immunogenicity: Potential Confounders in in Vivo Cell Tracking Experiments. Stem Cell Rev. 2016;12:553.

Article  CAS  PubMed Central  Google Scholar 

McCarty DM. Self-complementary AAV vectors; advances and applications. Mol Ther. 2008;16:1648–56.

Article  CAS  PubMed  Google Scholar 

Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, et al. AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction. Mol Ther. 2014;22:329–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramsingh AI, Gray SJ, Reilly A, Koday M, Bratt D, Koday MT, et al. Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation. PLoS ONE. 2018;13:e0198154.

Article  PubMed  PubMed Central  Google Scholar 

Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, et al. Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 2011;3:88ra54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao G, Wang Q, Calcedo R, Mays L, Bells P, Wang L, et al. Adeno-Associated Virus-Mediated Gene Transferto Nonhuman Primate Liver Can Elicit Destructive Transgene-Specific T Cell Responses. Hum Gene Ther. 2009;20:930–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boyd RF, Boye SL, Conlon TJ, Erger KE, Sledge DG, Langohr IM, et al. Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs. Gene Ther. 2016;23:548–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bodh SA, Kumar V, Raina UK, Ghosh B, Thakar M. Inflammatory glaucoma. Oman J Ophthalmol. 2011;4:3–9.

Sen HN, Drye LT, Goldstein DA, Larson TA, Merrill PT, Pavan PR, et al. Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) trial. Ocul Immunol Inflamm. 2012;20:104–12.

Article  PubMed  PubMed Central  Google Scholar 

Tran VT, Mermoud A, Herbort CP. Appraisal and Management of Ocular Hypotony and Glaucoma Associated With Uveitis. Int Ophthalmol Clin. 2000;40:175–203.

Article  CAS  PubMed  Google Scholar 

Casanova MI, Young L, Park S, Kim S, Roszak K, Leonard BC, et al. Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques (Macaca mulatta). Transl Vis Sci Technol. 2022;11:23.

Article  PubMed  PubMed Central  Google Scholar 

Choi KE, Anh VTQ, Yun C, Kim YJ, Jung H, Eom H, et al. Normative data of ocular biometry, optical coherence tomography, and electrophysiology conducted for cynomolgus macaque monkeys. Transl Vis Sci Technol. 2021;10:14.

Article  PubMed  PubMed Central  Google Scholar 

Denk Id N, Maloca Id P, Steiner G, Freichel C, Bassett S, Schnitzer TK, et al. Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT). 2019;14:e0222850.

Chern KJ, Nettesheim ER, Reid CA, Li NW, Marcoe GJ, Lipinski DM. Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats. Commun Biol. 2022;5:1169.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boutin S, Monteilhet V, Veron P, Leborgne C, Benveniste O, Franç Oise Montus M, et al. Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors. Hum Gene Ther. 2010;21:661–789.

Article  Google Scholar 

留言 (0)

沒有登入
gif