Brain-based gene expression of putative risk genes for anorexia nervosa

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.

Fichter MM, Quadflieg N, Crosby RD, Koch S. Long-term outcome of anorexia nervosa: results from a large clinical longitudinal study. Int J Eat Disord. 2017;50:1018–30.

Article  PubMed  Google Scholar 

Murray SB, Quintana DS, Loeb KL, Griffiths S, Le Grange D. Treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized controlled trials. Psychological Med. 2019;49:535–44.

Article  Google Scholar 

Lilenfeld LR, Kaye WH, Greeno CG, Merikangas KR, Plotnicov K, Pollice C, et al. A controlled family study of anorexia nervosa and bulimia nervosa: Psychiatric disorders in first-degree relatives and effects of proband comorbidity. Arch Gen Psychiatry. 1998;55:603–10.

Article  CAS  PubMed  Google Scholar 

Strober M, Freeman R, Lampert C, Diamond J, Kaye WH. Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes. Am J Psychiatry. 2000;157:393–401.

Article  CAS  PubMed  Google Scholar 

Bulik CM, Sullivan PF, Tozzi F, Furberg H, Lichtenstein P, Pedersen NL. Prevalence, heritability, and prospective risk factors for anorexia nervosa. Arch Gen Psychiatry. 2006;63:305–12.

Article  PubMed  Google Scholar 

Bulik CM, Thornton LM, Root TL, Pisetsky EM, Lichtenstein P, Pedersen NL. Sample. Understanding the relation between anorexia nervosa and bulimia nervosa in a Swedish national twin sample. Biol Psychiatry. 2010;67:71–77.

Article  PubMed  PubMed Central  Google Scholar 

Klump KL, Keel PK, McGue M, Iacono WG. Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample. Psychological Med. 2001;31:737–40.

Article  CAS  Google Scholar 

Wade TD, Bulik CM, Neale M, Kendler KS. Anorexia nervosa and major depression: shared genetic and environmental risk factors. Am J Psychiatry. 2000;157:469–71.

Article  CAS  PubMed  Google Scholar 

Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V, et al. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry. 2017;174:850–8.

Article  PubMed  PubMed Central  Google Scholar 

Negraes PD, Cugola FR, Herai RH, Trujillo CA, Cristino AS, Chailangkarn T, et al. Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons. Transl Psychiatry. 2017;7:e1060.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lutter M, Bahl E, Hannah C, Hofammann D, Acevedo S, Cui H, et al. Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors. PLoS One. 2017;12:e0181556.

Article  PubMed  PubMed Central  Google Scholar 

Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, et al. A genome-wide association study of anorexia nervosa. Mol Psychiatry. 2014;19:1085–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakabayashi K, Komaki G, Tajima A, Ando T, Ishikawa M, Nomoto J, et al. Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers. J Hum Genet. 2009;54:531–7.

Article  CAS  PubMed  Google Scholar 

Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, et al. A genome wide association study on common SNPs and rare CNVs in anorexia nervosa. Mol Psychiatry. 2011;16:949–59.

Article  CAS  PubMed  Google Scholar 

Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JRI, Gaspar HA, et al. Genome-wide association study identifies eight risk loci and implicates metabo psychiatric origins for anorexia nervosa. Nat Genet. 2019;51:1207–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jaffe AE, Deep-Soboslay A, Tao R, Hauptman DT, Kaye WH, Arango V, et al. Genetic neuropathology of obsessive psychiatric syndromes. Transl Psychiatry. 2014;4:e432.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kleinman JE, Law AJ, Lipska BK, Hyde TM, Ellis JK, Harrison PJ, et al. Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains. Biol Psychiatry. 2011;2:140–5.

Article  Google Scholar 

Hawrylycz M, Miller JA, Menon V, Feng D, Dolbeare T, Guillozet-Bongaarts AL, et al. Canonical genetic signatures of the adult human brain. Nat Neurosci. 2015;18:1832–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova Palomera A, et al. Oxytocin pathway gene networks in the human brain. Nat Commun. 2019;10:668.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watanabe K, Taskesen E, Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Nat Commun. 2017;8:1826.

Article  PubMed  PubMed Central  Google Scholar 

Kaye WH, Fudge JL, Paulus M. New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci. 2009;10:573–84.

Article  CAS  PubMed  Google Scholar 

Petrovich GD, Ross CA, Mody P, Holland PC, Gallagher M. Central, but not basolateral, amygdala is critical for control of feeding by aversive learned cues. J Neurosci Off J Soc Neurosci. 2009;29:15205–12.

Article  CAS  Google Scholar 

Petrovich GD, Gallagher M. Amygdala subsystems and control of feeding behavior by learned cues. Ann N Y Acad Sci. 2003;985:251–62.

Article  PubMed  Google Scholar 

Soria-Gomez E, Bellocchio L, Marsicano G. New insights on food intake control by olfactory processes: the emerging role of the endocannabinoid system. Mol Cell Endocrinol. 2014;397:59–66.

Article  CAS  PubMed  Google Scholar 

Browning KN, Carson KE. Central neurocircuits regulating food intake in response to gut inputs-preclinical evidence. Nutrients. 2021;13:908. (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197–206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loos RJ, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. 2022;23:120133.

Article  Google Scholar 

Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, et al. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nat Neurosci. 2017;20:1096–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steinhaussen HC. The outcome of anorexia nervosa in the 20th century. Am J Psychiatry. 2002;159:1284–93.

Article  Google Scholar 

Murray SB, Quintana DS, Loeb K, Griffiths S, Le Grange D. Treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized controlled trials. Psychological Med. 2019;49:535–44.

Article  Google Scholar 

Thomas LA, Akins MR, Biederer T. Expression and adhesion profiles of SynCAM molecules indicate distinct neuronal functions. J Comp Neurol. 2008;510:47–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lozano R, Gbekie C, Siper PM, Srivastava S, Saland JM, Sethuram S, et al. FOXP1 syndrome: a review of the literature and practice parameters for medical assessment and monitoring. J Neurodev Disord. 2021;13:18.

Article  PubMed  PubMed Central  Google Scholar 

The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21.

Article  Google Scholar 

Chien W-H, Gau SS-F, Chen C-H, Tsai W-C, Wu Y-Y, Chen P-H, et al. Increased gene expression of FOXP1 in patients with autism spectrum disorders. Mol Autism. 2013;4:23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siper PM, De Rubeis S, Trelles MDP, Durkin A, Di Marino D, Muratet F, et al. Prospective investigation of FOXP1 syndrome. Mol Autism. 2017;8:57.

Article  PubMed  PubMed Central  Google Scholar 

Hamdan FF, Daoud H, Rochefort D, Piton A, Gauthier J, Langlois M, et al. De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment. Am J Hum Genet. 2010;87:671–8.

Article  CAS 

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