Protective mechanisms from natural microbe-rich environments (e.g., traditional farms) may prevent allergic diseases.

The allergy-protective effects of natural environmental microbial exposures require innate immunity.

Pharmacological-grade bacterial lysates that engage innate immunity and block experimental asthma may prevent allergic disease.

Allergic diseases typically begin in early life and can impose a heavy burden on children and their families. Effective preventive measures are currently unavailable but may be ushered in by studies on the “farm effect”, the strong protection from asthma and allergy found in children born and raised on traditional farms. Two decades of epidemiologic and immunologic research have demonstrated that this protection is provided by early and intense exposure to farm-associated microbes that target primarily innate immune pathways. Farm exposure also promotes timely maturation of the gut microbiome, which mediates a proportion of the protection conferred by the farm effect.

Current research seeks to identify allergy-protective compounds from traditional farm environments, but standardization and regulation of such substances will likely prove challenging. On the other hand, studies in mouse models show that administration of standardized, pharmacological-grade lysates of human airway bacteria abrogates allergic lung inflammation by acting on multiple innate immune targets, including the airway epithelium/IL-33/ILC2 axis and dendritic cells whose Myd88/Trif-dependent tolerogenic reprogramming is sufficient for asthma protection in adoptive transfer models. To the extent that these bacterial lysates mimic the protective effects of natural exposure to microbe-rich environments, these agents might provide an effective tool for prevention of allergic disease.

airway hyperresponsiveness

bronchoalveolar lavage

G protein-coupled receptor

Protection against Allergy: Study in Rural Environments

Peripheral blood leukocyte

short-chain fatty acid

Allergic disease

Protection

Farm effect

Farm dust extract

Bacterial lysates

© 2023 Published by Elsevier Ltd.