*Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, Minnesota;

†School of Public Health, University of Minnesota, Minnesota;

‡Department of Ophthalmology & Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin;

§Division of Epidemiology and Clinical Applications, National Eye Institute (NEI), Bethesda, Maryland;

¶The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California; and

**Division of Endocrinology and Metabolism, Department of Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California.

Reprint requests: Michael Y. Tsai, PhD, Department of Laboratory Medicine and Pathology, University of Minnesota, 312 Church St. SE, NHH 3-110 Minneapolis, MN; e-mail: [email protected]

Supported by the Multi-Ethnic Study of Atherosclerosis (MESA) contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences (NCATS). This article was also supported in part by the Genetics of Latinos Diabetic Retinopathy (GOLDR) Study grant EY14684. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. This manuscript is dedicated to the late Dr. Ronald Klein, who passed away on August 31, 2019. Dr. Klein served as co-principal investigator for the MESA study and was strongly involved in the GOLDR study, providing instrumental expertise on the epidemiology of eye diseases.

No conflicting relationship or proprietary interests exists for any author.

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