Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Arain MA, Sawhney M, Sheikh S, et al. CIMP status of interval colon cancers: another piece to the puzzle. Am J Gastroenterol. 2010;105:1189–95.

PubMed  Google Scholar 

Cooper GS, Xu F, Barnholtz Sloan JS, et al. Prevalence and predictors of interval colorectal cancers in medicare beneficiaries. Cancer. 2012;118:3044–52.

PubMed  Google Scholar 

Gorski TF, Rosen L, Riether R, et al. Colorectal cancer after surveillance colonoscopy: false-negative examination or fast growth? Dis Colon Rectum. 1999;42:877–80.

CAS  PubMed  Google Scholar 

Lee YM, Huh KC. Clinical and biological features of interval colorectal cancer. Clin Endosc. 2017;50:254–60.

PubMed  PubMed Central  Google Scholar 

Singh H, Nugent Z, Demers AA, et al. Rate and predictors of early/missed colorectal cancers after colonoscopy in Manitoba: a population-based study. Am J Gastroenterol. 2010;105:2588–96.

PubMed  Google Scholar 

Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol. 1990;14:524–37.

CAS  PubMed  Google Scholar 

Goldman H, Ming S, Hickock DF. Nature and significance of hyperplastic polyps of the human colon. Arch Pathol. 1970;89:349–4.

CAS  PubMed  Google Scholar 

Ij JE, Vermeulen L, Meijer GA, et al. Serrated neoplasia-role in colorectal carcinogenesis and clinical implications. Nat Rev Gastroenterol Hepatol. 2015;12:401–9.

Google Scholar 

Leggett B, Whitehall V. Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology. 2010;138:2088–100.

CAS  PubMed  Google Scholar 

Bettington M, Walker N, Clouston A, et al. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology. 2013;62:367–86.

PubMed  Google Scholar 

O’Brien MJ, Zhao Q, Yang S. Colorectal serrated pathway cancers and precursors. Histopathology. 2015;66:49–65.

PubMed  Google Scholar 

Rosty C, Hewett DG, Brown IS, et al. Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. J Gastroenterol. 2013;48:287–302.

PubMed  Google Scholar 

Lash RH, Genta RM, Schuler CM. Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients. J Clin Pathol. 2010;63:681–6.

PubMed  Google Scholar 

Bettington M, Walker N, Rosty C, et al. Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut. 2017;66:97–106.

CAS  PubMed  Google Scholar 

Murakami T, Kurosawa T, Fukushima H, et al. Sessile serrated lesions: clinicopathological characteristics, endoscopic diagnosis, and management. Dig Endosc. 2022;34:1096–109.

PubMed  Google Scholar 

Burgess NG, Tutticci NJ, Pellise M, et al. Sessile serrated adenomas/polyps with cytologic dysplasia: a triple threat for interval cancer. Gastrointest Endosc. 2014;80:307–10.

PubMed  Google Scholar 

Nanda KS, Tutticci N, Burgess N, et al. Caught in the act: endoscopic characterization of sessile serrated adenomas with dysplasia. Gastrointest Endosc. 2014;79:864–70.

PubMed  Google Scholar 

Pohl H, Srivastava A, Bensen SP, et al. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology. 2013;144:74-80.e1.

PubMed  Google Scholar 

Kamba S, Tamai N, Saitoh I, et al. Reducing adenoma miss rate of colonoscopy assisted by artificial intelligence: a multicenter randomized controlled trial. J Gastroenterol. 2021;56:746–57.

PubMed  Google Scholar 

Pei L, Liu Y, Liu L, et al. Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers. Mol Cancer. 2023;22:29.

PubMed  PubMed Central  Google Scholar 

Jin Z, Sinicrope FA. Mismatch repair-deficient colorectal cancer: building on checkpoint blockade. J Clin Oncol. 2022;40:2735–50.

CAS  PubMed  Google Scholar 

Anderson NM, Simon MC. The tumor microenvironment. Curr Biol. 2020;30:R921-5.

CAS  PubMed  PubMed Central  Google Scholar 

WHO Classification of Tumours Editorial Board. WHO Classification of Tumors: Digestive System Tumours. 5th ed. Lyon: International Agency for Reasearch on Cancer; 2019.

Google Scholar 

Crockett SD, Nagtegaal ID. Terminology, molecular features, epidemiology, and management of serrated colorectal neoplasia. Gastroenterology. 2019;157:949-66.e4.

PubMed  Google Scholar 

Mezzapesa M, Losurdo G, Celiberto F, et al. Serrated colorectal lesions: an up-to-date review from histological pattern to molecular pathogenesis. Int J Mol Sci. 2022;23:4461.

CAS  PubMed  PubMed Central  Google Scholar 

Bettington M, Walker N, Rosty C, et al. Critical appraisal of the diagnosis of the sessile serrated adenoma. Am J Surg Pathol. 2014;38:158–66.

PubMed  Google Scholar 

Torlakovic E, Skovlund E, Snover DC, et al. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol. 2003;27:65–81.

PubMed  Google Scholar 

Kambara T, Simms LA, Whitehall VL, et al. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut. 2004;53:1137–44.

CAS  PubMed  PubMed Central  Google Scholar 

Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology. 2007;50:113–30.

CAS  PubMed  Google Scholar 

Sheridan TB, Fenton H, Lewin MR, et al. Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions “caught in the act.” Am J Clin Pathol. 2006;126:564–71.

PubMed  Google Scholar 

Goldstein NS, Bhanot P, Odish E, et al. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol. 2003;119:778–96.

PubMed  Google Scholar 

Phipps AI, Limburg PJ, Baron JA, et al. Association between molecular subtypes of colorectal cancer and patient survival. Gastroenterology. 2015;148:77-87.e2.

CAS  PubMed  Google Scholar 

Hazewinkel Y, de Wijkerslooth TR, Stoop EM, et al. Prevalence of serrated polyps and association with synchronous advanced neoplasia in screening colonoscopy. Endoscopy. 2014;46:219–24.

PubMed  Google Scholar 

Carr NJ, Mahajan H, Tan KL, et al. Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J Clin Pathol. 2009;62:516–8.

CAS  PubMed  Google Scholar 

Torlakovic EE, Gomez JD, Driman DK, et al. Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol. 2008;32:21–9.

PubMed  Google Scholar 

Sano W, Hirata D, Teramoto A, et al. Serrated polyps of the colon and rectum: remove or not? World J Gastroenterol. 2020;26:2276–85.

PubMed  PubMed Central  Google Scholar 

McCarthy AJ, Serra S, Chetty R. Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis. BMJ Open Gastroenterol. 2019;6: e000317.

PubMed  PubMed Central  Google Scholar 

Bettington ML, Walker NI, Rosty C, et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Mod Pathol. 2015;28:414–27.

CAS  PubMed  Google Scholar 

Tsai JH, Liau JY, Lin YL, et al. Traditional serrated adenoma has two pathways of neoplastic progression that are distinct from the sessile serrated pathway of colorectal carcinogenesis. Mod Pathol. 2014;27:1375–85.

CAS  PubMed  Google Scholar 

Hashimoto T, Tanaka Y, Ogawa R, et al. Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion. Mod Pathol. 2018;31:1588–98.

CAS  PubMed  Google Scholar 

Mizuguchi Y, Tanaka Y, Cho H, et al. Endoscopic features of isolated and traditional serrated adenoma-associated superficially serrated adenomas of the colorectum. Dig Endosc. 2022;34:153–62.

PubMed  Google Scholar 

Togashi K. Superficially serrated adenoma: Novel precursor in the serrated pathway. Dig Endosc. 2022;34:77–8.

PubMed  Google Scholar 

Abdeljawad K, Vemulapalli KC, Kahi CJ, et al. Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist. Gastrointest Endosc. 2015;81:517–24.

PubMed  Google Scholar 

Ij JE, de Wit K, van der Vlugt M, et al. Prevalence, distribution and risk of sessile serrated adenomas/polyps at a center with a high adenoma detection rate and experienced pathologists. Endoscopy. 2016;48:740–6.

Google Scholar 

Kumbhari V, Behary J, Hui JM. Prevalence of adenomas and sessile serrated adenomas in Chinese compared with Caucasians. J Gastroenterol Hepatol. 2013;28:608–12.

PubMed  Google Scholar 

Snover DC. Sessile serrated adenoma/polyp of the large intestine: a potentially aggressive lesion in need of a new screening strategy. Dis Colon Rectum. 2011;54:1205–6.

PubMed  Google Scholar 

Yang JF, Tang SJ, Lash RH, et al. Anatomic distribution of sessile serrated adenoma/polyp with and without cytologic dysplasia. Arch Pathol Lab Med. 2015;139:388–93.

PubMed  Google Scholar 

Amemori S, Yamano HO, Tanaka Y, et al. Sessile serrated adenoma/polyp showed rapid malignant transformation in the final 13 months. Dig Endosc. 2020;32:979–83.

PubMed  Google Scholar 

Oono Y, Fu K, Nakamura H, et al. Progression of a sessile serrated adenoma to an early invasive cancer within 8 months. Dig Dis Sci. 2009;54:906–9.

PubMed