DERIVED-BAND AUDITORY BRAINSTEM RESPONSES: COCHLEAR CONTRIBUTIONS DETERMINED BY NARROWBAND MASKERS

Abstract

Objective The present study sought to determine the cochlear frequency regions represented by Audtory Brainstem Responses (ABRs) obtained using the high-pass noise/derived response (HP/DR) technique.

Design Broadband noise sufficient to mask the ABR to 50 dB nHL clicks was HP filtered (96 dB/oct) at 8000, 4000, 2000, 1000 and 500 Hz. Mixed with the clicks and high-pass noise masker was narrowband noise. Three DR bands, denoted by the upper and lower high-pass noise frequencies, were obtained: DR4000-2000, DR2000-1000, and DR1000-500.

Study sample Ten adults with normal hearing, aged 19-27 years (mean age: 22.4 years), were recruited from the community.

Results Frequencies contributing to each DR were determined from the wave V percent amplitude (or latency shift) vs narrowband masker frequency profiles (relative to a no-narrowband-noise condition). Overall, results indicate derived band center frequencies were closer to the lower HP cutoff frequencies for DR4000-2000 and DR2000-1000, and approximately halfway between the lower HP cutoff and the geometric mean of the two HP frequencies for DR1000-500, with bandwidths of 0.5-1 octave in width.

Conclusions These results confirm the validity of the HP/DR technique for assessing narrow cochlear regions (≤1.0 octave wide), with center frequencies within ½-octave of the lower HP cutoff frequency.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

Work supported by the Natural Sciences and Engineering Research Council (NSERC) of Canada Discovery Grant (#183923).

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

Research Ethics Board approval was obtained from the Behavioural Research Ethics Board of the University of British Columbia prior to commencement of the study.

I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.

Yes

I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

Yes

I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

Yes

Data Availability

The ABR wave V latency and amplitude data set used and/or analyzed in the current study are available from the corresponding author on reasonable request

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