Price, D., Fletcher, M. & Van Der Molen, T. Asthma control and management in 8,000 European patients: The REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey. NPJ Prim. Care Respir. Med. 24, 1–10 (2014).

Article  Google Scholar 

Demoly, P., Annunziata, K., Gubba, E. & Adamek, L. Repeated cross-sectional survey of patient-reported asthma control in europe in the past 5 years. Eur. Respir. Rev. 21, 66–74 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Partridge, M. R., van der Molen, T., Myrseth, S. E. & Busse, W. W. Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study. BMC Pulm. Med. 6, 1–9 (2006).

Article  Google Scholar 

Guilbert, T. W. et al. Asthma that is not well-controlled is associated with increased healthcare utilization and decreased quality of life. J. Asthma 48, 126–132 (2011).

Article  PubMed  Google Scholar 

Godard, P., Chanez, P., Siraudin, L., Nicoloyannis, N. & Duru, G. Costs of asthma are correlated with severity: a 1-yr prospective study. Eur. Respir. J. 19, 61–67 (2002).

Article  CAS  PubMed  Google Scholar 

Dekhuijzen, R., Lavorini, F., Usmani, O. S. & van Boven, J. F. M. Addressing the impact and unmet needs of nonadherence in asthma and chronic obstructive pulmonary disease: where do we go from here? J. Allergy Clin. Immunol. Pract. 6, 785–793 (2018).

Article  PubMed  Google Scholar 

Global Initiative for Asthma. Global strategy for asthma management and prevention. https://ginasthma.org/wp-content/uploads/2022/07/GINA-Main-Report-2022-FINAL-22-07-01-WMS.pdf (2022).

Engelkes, M., Janssens, H. M., De Jongste, J. C., Sturkenboom, M. C. J. M. & Verhamme, K. M. C. Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur. Respir. J. 45, 396–407 (2015).

Article  PubMed  Google Scholar 

Boulet, L. P., Vervloet, D., Magar, Y. & Foster, J. M. Adherence. The goal to control asthma. Clin. Chest Med. 33, 405–417 (2012).

Article  PubMed  Google Scholar 

Sabaté, E. & WHO (World Health Organisation). Adherence to Long-term Therapies: Evidence for Action (WHO, 2003).

Jansen, E. M. et al. Global burden of medication non-adherence in chronic obstructive pulmonary disease (COPD) and asthma: a narrative review of the clinical and economic case for smart inhalers. J. Thorac. Dis. https://doi.org/10.21037/jtd-20-2360 (2021).

Chan, A. H. Y., Harrison, J., Black, P. N., Mitchell, E. A. & Foster, J. M. Using electronic monitoring devices to measure inhaler adherence: a practical guide for clinicians. J. Allergy Clin. Immunol. Pract. 3, 335–349.e5 (2015).

Article  PubMed  Google Scholar 

Tinschert, P., Jakob, R., Barata, F., Kramer, J. N. & Kowatsch, T. The potential of mobile apps for improving asthma self-management: a review of publicly available and well-adopted asthma apps. JMIR Mhealth Uhealth 5, 1–13 (2017).

Article  Google Scholar 

Sulaiman, I. et al. A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma. Eur. Respir. J. 51, 701126 (2018).

Article  Google Scholar 

Foster, J. M. et al. Inhaler reminders improve adherence with controller treatment in primary care patients with asthma. J. Allergy Clin. Immunol. 134, 1260–1268 (2014).

Article  PubMed  Google Scholar 

Chan, A. H. Y. et al. The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial. Lancet Respir. Med. 3, 210–219 (2015).

Article  PubMed  Google Scholar 

Moore, A. et al. A randomised controlled trial of the effect of a connected inhaler system on medication adherence in uncontrolled asthmatic patients. Eur. Respir. J. 57, 2003103 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Morton, R. W. et al. STAAR: A randomised controlled trial of electronic adherence monitoring with reminder alarms and feedback to improve clinical outcomes for children with asthma. Thorax 72, 347–354 (2017).

Article  PubMed  Google Scholar 

Kuipers, E., Wensing, M., de Smet, P. & Teichert, M. Self-management research of asthma and good drug use (SMARAGD study): a pilot trial. Int. J. Clin. Pharm. 39, 888–896 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Nguyen, E., Miao, B., Pugliese, N., Huang, D. & Sobieraj, D. M. Systematic review of mHealth applications that interface with inhaler sensors in asthma. J. Allergy Clin. Immunol. Pract. 9, 844–852.e3 (2021).

Article  PubMed  Google Scholar 

Huckvale, K., Morrison, C., Ouyang, J., Ghaghda, A. & Car, J. The evolution of mobile apps for asthma: an updated systematic assessment of content and tools. BMC Med. 13, 1–15 (2015).

Article  CAS  Google Scholar 

Van Gemert-Pijnen, J. E. W. C. et al. A holistic framework to improve the uptake and impact of ehealth technologies. J. Med. Internet Res. 13, e111 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Odendaal, W. et al. Health workers’ perceptions and experiences of using mHealth technologies to deliver primary healthcare services: a qualitative evidence synthesis. Cochrane Database Syst. Rev. 3, CD011942 (2020).

PubMed  Google Scholar 

Himes, B. E., Leszinsky, L., Walsh, R., Hepner, H. & Wu, A. C. Mobile health and inhaler-based monitoring devices for asthma management. J. Allergy Clin. Immunol. Pract. 7, 2535–2543 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Alwashmi, M. F. et al. Perceptions of patients regarding mobile health interventions for the management of chronic obstructive pulmonary disease: mixed methods study. JMIR Mhealth Uhealth 8, e17409 (2020).

Howard, S., Lang, A., Sharples, S. & Shaw, D. What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective. BMJ Open Respir. Res. 3, 1–10 (2016).

Article  Google Scholar 

Kan, K. et al. Health provider perspectives of electronic medication monitoring in outpatient asthma care: a qualitative investigation using the consolidated framework for implementation research. J. Asthma 59, 342–351 (2022).

Article  PubMed  Google Scholar 

Slater, H., Campbell, J. M., Stinson, J. N., Burley, M. M. & Briggs, A. M. End User and implementer experiences of mhealth technologies for noncommunicable chronic disease management in young adults: Systematic review. J. Med. Internet Res. 19, e406 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Fernandez, M. E. et al. Implementation mapping: Using intervention mapping to develop implementation strategies. Front. Public Health 7, 1–15 (2019).

Article  Google Scholar 

Damschroder, L. J. et al. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement. Sci. 4, 1–15 (2009).

Article  Google Scholar 

Proctor, E. K., Powell, B. J. & McMillen, J. C. Implementation strategies: recommendations for specifying and reporting. Implement. Sci. 8, 1–11 (2013).

Article  Google Scholar 

Ritchie, J. & Lewis, J. Qualitative Research Practice: A Guide for Social Science Students and Researchers (Sage, 2003).

Tong, A., Sainsbury, P. & Craig, J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int. J. Qual. Health Care 19, 349–357 (2007).

Article  PubMed  Google Scholar 

Marshall, M. N. The key informant technique. Fam. Pract. 13, 92–97 (1996).

Article  CAS  PubMed  Google Scholar 

Moullin, J. C., Dickson, K. S., Stadnick, N. A., Rabin, B. & Aarons, G. A. Systematic review of the Exploration, Preparation, Implementation, Sustainment (EPIS) framework. Implement. Sci. 14, 1 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Juniper, E. F., O’Byrne, P., Guyatt, G., Ferrie, P. & King, D. Development and validation of a questionnaire to measure asthma control. Eur. Respir. J. 14, 902–907 (1999).

Article  CAS  PubMed  Google Scholar 

Juniper, E. F., Bousquet, J., Abetz, L. & Bateman, E. D. Identifying ‘well-controlled’ and ‘not well-controlled’ asthma using the Asthma Control Questionnaire. Respir. Med. 100, 616–621 (2006).

Article  PubMed  Google Scholar 

Gale, N. K., Heath, G., Cameron, E., Rashid, S. & Redwood, S. Using the framework method for the analysis of qualitative data in multi-disciplinary health research. BMC Med. Res. Methodol. 13, 117 (2013).

Article  PubMed  PubMed Central  Google Scholar 

van Gaalen, J. L., van Bodegom-Vos, L., Bakker, M. J., Snoeck-Stroband, J. B. & Sont, J. K. Internet-based self-management support for adults with asthma: a qualitative study among patients, general practitioners and practice nurses on barriers to implementation. BMJ Open 6, 1–9 (2016).

Google Scholar 

Tangari, G., Ikram, M., Ijaz, K., Kaafar, M. A. & Berkovsky, S. Mobile health and privacy: cross sectional study. BMJ 373, n1248 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Pinnock, H., Slack, R., Pagliari, C., Price, D. & Sheikh, A. Understanding the potential role of mobile phone-based monitoring on asthma self-management: qualitative study. Clin. Exp. Allergy 37, 794–802 (2007).

Article  CAS  PubMed  Google Scholar 

Moore, G., Wilding, H., Gray, K. & Castle, D. Participatory methods to engage health service users in the development of electronic health resources: systematic review. J. Particip. Med. 11, e11474 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Maramba, I., Chatterjee, A. & Newman, C. Methods of usability testing in the development of eHealth applications: a scoping review. Int. J. Med. Inf. 126, 95–104 (2019).

Article  Google Scholar 

Eysenbach, G. et al. ConSORT-eHealth: Improving and standardizing evaluation reports of web-based and mobile health interventions. J. Med. Internet Res. 13, e126 (2011).

Granja, C., Janssen, W. & Johansen, M. A. Factors determining the success and failure of ehealth interventions: systematic review of the literature. J. Med. Internet Res. 20, 1–21 (2018).

Article  Google Scholar 

Schneider, T. et al. Physicians’ perceptions of mobile technology for enhancing asthma care for youth. J. Child Health Care 20, 153–163 (2016).