Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, et al. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA. 1987;84:9233–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murphy PM, Baggiolini M, Charo IF, Hébert CA, Horuk R, Matsushima K, et al. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharm Rev. 2000;52:145–76.

CAS  PubMed  Google Scholar 

Zlotnik A, Yoshie O. The chemokine superfamily revisited. Immunity. 2012;36:705–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vilgelm AE, Richmond A. Chemokines modulate immune surveillance in tumorigenesis, metastasis, and response to immunotherapy. Front Immunol. 2019;10:333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karin N. Chemokines in the landscape of cancer immunotherapy: How they and their receptors can be used to turn cold tumors into hot ones. Cancers. 2021;13:6317.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozga AJ, Chow MT, Luster AD. Chemokines and the immune response to cancer. Immunity. 2021;54:859–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxena S, Singh RK. Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity. Cancer Metastasis Rev. 2021;40:447–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Li JQ, Chen QL, Shestakova EA, Misyurin VA, Pokrovsky VS, et al. Advances in research on the effects and mechanisms of chemokines and their receptors in cancer. Front Pharm. 2022;13:920779.

Article  CAS  Google Scholar 

Yoshimura T. The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally. Cell Mol Immunol. 2018;15:335–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshimura T, Robinson EA, Tanaka S, Appella E, Leonard EJ. Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes. J Immunol. 1989;142:1956–62.

Article  CAS  PubMed  Google Scholar 

Yoshimura T, Robinson EA, Tanaka S, Appella E, Kuratsu J, Leonard EJ. Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med. 1989;169:1449–59.

Article  CAS  PubMed  Google Scholar 

Bottazzi B, Colotta F, Sica A, Nobili N, Mantovani A. A chemoattractant expressed in human sarcoma cells (tumor-derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF). Int J Cancer. 1990;45:795–7.

Article  CAS  PubMed  Google Scholar 

Kuratsu J, Yoshizato K, Yoshimura T, Leonard EJ, Takeshima H, Ushio Y. Quantitative study of monocyte chemoattractant protein-1 (MCP-1) in cerebrospinal fluid and cyst fluid from patients with malignant glioma. J Natl Cancer Inst. 1993;85:1836–9.

Article  CAS  PubMed  Google Scholar 

Takeshima H, Kuratsu J, Takeya M, Yoshimura T, Ushio Y. Expression and localization of messenger RNA and protein for monocyte chemoattractant protein-1 in human malignant glioma. J Neurosurg. 1994;80:1056–62.

Article  CAS  PubMed  Google Scholar 

Sato K, Kuratsu J, Takeshima H, Yoshimura T, Ushio Y. Expression of monocyte chemoattractant protein-1 in meningioma. J Neurosurg. 1995;82:874–8.

Article  CAS  PubMed  Google Scholar 

Negus RP, Stamp GW, Relf MG, Burke F, Malik ST, Bernasconi S, et al. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J Clin Invest. 1995;95:2391–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arenberg DA, Keane MP, DiGiovine B, Kunkel SL, Strom SR, Burdick MD, et al. Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines. Cancer Immunol Immunother. 2000;49:63–70.

Article  CAS  PubMed  Google Scholar 

O’Sullivan C, Lewis CE. Tumour-associated leucocytes: friends or foes in breast carcinoma. J Pathol. 1994;172:229–35.

Article  PubMed  Google Scholar 

Zachariae CO, Anderson AO, Thompson HL, Appella E, Mantovani A, Oppenheim JJ, et al. Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. J Exp Med. 1990;171:2177–82.

Article  CAS  PubMed  Google Scholar 

Rollins BJ, Sunday ME. Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. Mol Cell Biol. 1991;11:3125–31.

CAS  PubMed  PubMed Central  Google Scholar 

Walter S, Bottazzi B, Govoni D, Colotta F, Mantovani A. Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE. Int J Cancer. 1991;49:431–5.

Article  CAS  PubMed  Google Scholar 

Manome Y, Wen PY, Hershowitz A, Tanaka T, Rollins BJ, Kufe DW, et al. Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. Cancer Immunol Immunother. 1995;41:227–35.

Article  CAS  PubMed  Google Scholar 

Nakashima E, Mukaida N, Kubota Y, Kuno K, Yasumoto K, Ichimura F, et al. Human MCAF gene transfer enhances the metastatic capacity of a mouse cachectic adenocarcinoma cell line in vivo. Pharm Res. 1995;12:1598–604.

Article  CAS  PubMed  Google Scholar 

Kadomoto S, Izumi K, Mizokami A. Roles of CCL2-CCR2 axis in the tumor microenvironment. Int J Mol Sci. 2021;22:8530.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin X, Mu P. Targeting breast cancer metastasis. Breast Cancer. 2015;9:23–34.

PubMed  PubMed Central  Google Scholar 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, et al. Cancer statistics for the year 2020: An overview. Int J Cancer. 2021;149:778–89.

Lüönd F, Tiede S, Christofori G. Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression. Br J Cancer. 2021;125:164–75.

Article  PubMed  PubMed Central  Google Scholar 

Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000;12:121–7.

Article  CAS  PubMed  Google Scholar 

Valković T, Lucin K, Krstulja M, Dobi-Babić R, Jonjić N. Expression of monocyte chemotactic protein-1 in human invasive ductal breast cancer. Pathol Res Pr. 1998;194:335–40.

Article  Google Scholar 

Valković T, Fuckar D, Stifter S, Matusan K, Hasan M, Dobrila F, et al. Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma. J Cancer Res Clin Oncol. 2005;131:453–8.

Article  PubMed  Google Scholar 

Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res. 2000;6:3282–9.

CAS  PubMed  Google Scholar 

Saji H, Koike M, Yamori T, Saji S, Seiki M, Matsushima K, et al. Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer. 2001;92:1085–91.

Article  CAS  PubMed  Google Scholar 

Chavey C, Bibeau F, Gourgou-Bourgade S, Burlinchon S, Boissière F, Laune D, et al. Oestrogen receptor negative breast cancers exhibit high cytokine content. Breast Cancer Res. 2007;9:R15.

Article  PubMed  PubMed Central  Google Scholar 

Fujimoto H, Sangai T, Ishii G, Ikehara A, Nagashima T, Miyazaki M, et al. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int J Cancer. 2009;125:1276–84.

Article  CAS  PubMed  Google Scholar 

Soria G, Ofri-Shahak M, Haas I, Yaal-Hahoshen N, Leider-Trejo L, Leibovich-Rivkin T, et al. Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer. 2011;11:130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katanov C, Lerrer S, Liubomirski Y, Leider-Trejo L, Meshel T, Bar J, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway. Stem Cell Res Ther. 2015;6:87.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Zhuang ZG, Xu SF, He Q, Shao YG, Ji M, et al. Expression of CCL2 is significantly different in five breast cancer genotypes and predicts patient outcome. Int J Clin Exp Med. 2015;8:15684–91.

CAS