Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 2021;71(3):209–249. https://doi.org/10.3322/caac.21660.

Jacob S, et al. An updated overview of the emerging role of patch and film-based buccal delivery systems. 2021;13(8):1206. https://doi.org/10.3390/pharmaceutics13081206.

Article  CAS  Google Scholar 

Lechanteur AJ. das Neves, and B.J.A.d.d.r. Sarmento, The role of mucus in cell-based models used to screen mucosal drug delivery. 2018;124:50–63. https://doi.org/10.1016/j.addr.2017.07.019.

Hu S, et al. A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery. 2021;12(1):1–17. https://doi.org/10.1038/s41467-021-21989-5.

Article  CAS  Google Scholar 

Habib L, et al. A mucoadhesive patch loaded with freeze-dried liposomes for the local treatment of oral tumors. 2022;p. 1–18. https://doi.org/10.1007/s13346-022-01224-4.

Kumar A, et al. Fabrication and analysis of chitosan oligosaccharide based mucoadhesive patch for oromucosal drug delivery. 2022(just-accepted): p. 1–28. https://doi.org/10.1080/03639045.2022.2146705.

Alaei S, Omidian H. Mucoadhesion and mechanical assessment of oral films. 2021;159:105727. https://doi.org/10.1016/j.ejps.2021.105727.

Gau M, et al. Induction chemotherapy in head and neck cancers: results and controversies. 2019;95:164–9. https://doi.org/10.1016/j.oraloncology.2019.06.015.

Article  CAS  Google Scholar 

Li F, Zhang NJ. Ceramide: therapeutic potential in combination therapy for cancer treatment. 2016;17(1): 37–51. https://doi.org/10.2174/1389200216666151103120338.

Yang L, et al. C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study. 2015;332(1):47–59. https://doi.org/10.1016/j.yexcr.2014.12.017.

Siemann U. Solvent cast technology–a versatile tool for thin film production, in Scattering methods and the properties of polymer materials. 2005;1–14. https://doi.org/10.1007/b107336.

Tsutsumi K, et al. Formulation of buccal mucoadhesive dosage form of ergotamine tartrate. 1994;4(3):230–4.

CAS  Google Scholar 

Remuñán-López C, et al. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. 1998;55(2–3):143–52. https://doi.org/10.1016/s0168-3659(98)00044-3.

Article  Google Scholar 

Choi JS, Park JS, Biointerfaces SB. Surface modification of docetaxel nanocrystals with HER2 antibody to enhance cell growth inhibition in breast cancer cells. 2017;159:139–150. https://doi.org/10.1016/j.colsurfb.2017.07.064.

Chahal S, et al. Biomimetic growth of bone-like apatite via simulated body fluid on hydroxyethyl cellulose/polyvinyl alcohol electrospun nanofibers. 2014;24(1):799–806. https://doi.org/10.3233/BME-130871.

Article  CAS  Google Scholar 

Zulkifli FH, et al. Improved cellular response of chemically crosslinked collagen incorporated hydroxyethyl cellulose/poly (vinyl) alcohol nanofibers scaffold. 2015;29(7):1014–1027. https://doi.org/10.1177/0885328214549818.

Asati S, et al. Bioadhesive or mucoadhesive drug delivery system: a potential alternative to conventional therapy. 2019;9(4-A):858–867. https://doi.org/10.22270/jddt.v9i4-A.3708.

Marques MR, Loebenberg R, Almukainzi MJDT. Simulated biological fluids with possible application in dissolution testing. 2011;18(3):15–28. https://doi.org/10.14227/DT180311P15.

Article  CAS  Google Scholar 

Abouhussein D, et al. Cetylpyridinium chloride chitosan blended mucoadhesive buccal films for treatment of pediatric oral diseases. 2020;57:101676. https://doi.org/10.1016/j.jddst.2020.101676.

Jacobi U, et al. The porcine snout–an in vitro model for human lips? 2005;14(2):96–102. https://doi.org/10.1111/j.0906-6705.2005.00223.x.

Campisi G, et al. Carbamazepine transbuccal delivery: the histo-morphological features of reconstituted human oral epithelium and buccal porcine mucosae in the transmucosal permeation. 2008;21(4):903–10. https://doi.org/10.1177/039463200802100414.

Article  CAS  Google Scholar 

Bhattacharjee S, et al. Design, development and evaluation of mucoadhesive film for water insoluble drug using different plasticizers. 2014;6(3):107–110.

Koland M, Charyulu R, Prabhu PJ. Mucoadhesive films of losartan potassium for buccal delivery: design and characterization. 2010;44(4):315–23.

Patel KN, Patel HK, Patel VA. Formulation and characterization of drug in adhesive transdermal patches of diclofenac acid. 2012;4(1):296–9.

Rohani Shirvan A, et al. Fabrication of multifunctional mucoadhesive buccal patch for drug delivery applications. 2021;109(12):2640–56. https://doi.org/10.1002/jbm.a.37257.

Article  CAS  Google Scholar 

Nair AB, et al. In vitro techniques to evaluate buccal films. 2013;166(1):10–21. https://doi.org/10.1016/j.jconrel.2012.11.019.

Article  CAS  Google Scholar 

Hermans K, et al. Development and characterization of mucoadhesive chitosan films for ophthalmic delivery of cyclosporine A. 2014;472(1–2):10–9. https://doi.org/10.1016/j.ijpharm.2014.06.017.

Article  CAS  Google Scholar 

Peppas NJ. Analysis of Fickian and non-Fickian drug release from polymers. 1985;60(4):110–111.

Ritger PL, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. 1987;5(1):37–42.

Korsmeyer RW. GurnyR., Doelker E., Buri P., Peppas NA. 1983;15:25.

Zhang Y, et al. DDSolver: an add-in program for modeling and comparison of drug dissolution profiles. 2010;12(3):263–271. https://doi.org/10.1208/s12248-010-9185-1.

Rodriguez CF, et al. Hydrophilic cellulose derivatives as drug delivery carriers: influence of substitution type on the properties. 2000; p. 1–30.

Conti S, et al. Matrices containing NaCMC and HPMC: 2 Swelling and release mechanism study. 2007;333(1–2):143–151. https://doi.org/10.1016/j.ijpharm.2006.11.067.

Karakurt I, et al. Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends. 2021;126:112125. https://doi.org/10.1016/j.msec.2021.112125.

Nafee NA, et al. Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing. 2003;264(1–2):1–14. https://doi.org/10.1016/s0378-5173(03)00371-5.

Article  CAS  Google Scholar 

Tang YF, et al. Rheological characterisation of a novel thermosensitive chitosan/poly (vinyl alcohol) blend hydrogel. 2007;67(4):491–499. https://doi.org/10.1016/j.carbpol.2006.06.015.

Latif MS, et al. Formulation and evaluation of hydrophilic polymer based methotrexate patches: in vitro and in vivo characterization. 2022;14(7):1310. https://doi.org/10.3390/polym14071310.

Article  CAS  Google Scholar 

Kolluru LP, et al. Development and evaluation of polycaprolactone based docetaxel nanoparticle formulation for targeted breast cancer therapy. 2020;22(12):1–14. https://doi.org/10.1007/s11051-020-05096-y.

Article  CAS  Google Scholar 

Queiroz MF, et al. Does the use of chitosan contribute to oxalate kidney stone formation? 2014;13(1):141–158. https://doi.org/10.3390/md13010141.

Tatini LK, Krishna Reddy K, Someswara Rao NJ. Vapor-induced phase transformations in docetaxel. 2012;13:548–555.

El Fawal G, et al. Fabrication of antimicrobial films based on hydroxyethylcellulose and ZnO for food packaging application. 2020;23:100462. https://doi.org/10.1016/j.fpsl.2020.100462.

Hu H, et al. Glutaraldehyde–chitosan and poly (vinyl alcohol) blends, and fluorescence of their nano-silica composite films. 2013;91(1):305–313. https://doi.org/10.1016/j.carbpol.2012.08.038.

Calvo NL, et al. Chitosan-hydroxypropyl methylcellulose tioconazole films: a promising alternative dosage form for the treatment of vaginal candidiasis. 2019;556:181–91. https://doi.org/10.1016/j.ijpharm.2018.12.011.

Article  CAS  Google Scholar 

Albarkah YA, Green RJ, Khutoryanskiy VV. Probing the mucoadhesive interactions between porcine gastric mucin and some water‐soluble polymers. 2015;15(11):1546–1553. https://doi.org/10.1002/mabi.201500158.

Chen L, et al. Starch-polyvinyl alcohol crosslinked film—performance and biodegradation. 1997;5(2):p. 111–117. https://doi.org/10.1007/BF02763594.

Sip S, et al. Chitosan as valuable excipient for oral and topical carvedilol delivery systems. 2021;14(8):712. https://doi.org/10.3390/ph14080712.

Article  CAS  Google Scholar 

Huang W, et al. Using spray-dried lactose monohydrate in wet granulation method for a low-dose oral formulation of a paliperidone derivative. 2013;246:379–94. https://doi.org/10.1016/j.powtec.2013.05.042.

Article  CAS  Google Scholar 

Yehia SA, El-Gazayerly ON, Basalious EB. Fluconazole mucoadhesive buccal films: in vitro/in vivo performance. 2009;6(1):17–27. https://doi.org/10.2174/156720109787048195.

Brazel CS, Peppas NA. Modeling of drug release from swellable polymers. 2000;49(1):47–58. https://doi.org/10.1016/s0939-6411(99)00058-2.

Chang YC, et al. Exogenous C8-Ceramide induces apoptosis by overproduction of ROS and the switch of superoxide dismutases SOD1 to SOD2 in human lung cancer cells. 2018;19(10):3010. https://doi.org/10.3390/ijms19103010.