Long-term supplementation with 3200 to 4000 IU of vitamin D daily and adverse events: a systematic review and meta-analysis of randomized controlled trials

Zittermann A, Prokop S, Gummert JF, Börgermann J (2013) Safety issues of vitamin D supplementation. Anticancer Agents Med Chem 13:4–10. https://doi.org/10.2174/187152013804487290

Article  CAS  PubMed  Google Scholar 

IOM (Institute of Medicine) (2011) Dietary reference intakes for calcium and vitamin D. The National Academies Press, Washington

Google Scholar 

EFSA Panel on Dietetic Products Nutrition and Allergies (NDA) (2012) Scientific opinion on the tolerable upper intake level of vitamin D. EFSA J 10:2813. https://doi.org/10.2903/j.efsa.2012.2813

Article  CAS  Google Scholar 

European Food Safety Authority. Dietary reference values. https://www.efsa.europa.eu/en/topics/topic/dietary-reference-values. Assessed 2 February 2023

Malihi Z, Wu Z, Lawes CMM, Scragg R (2019) Adverse events from large dose vitamin D supplementation taken for one year or longer. J Steroid Biochem Mol Biol 188:29–37. https://doi.org/10.1016/j.jsbmb.2018.12.002

Article  CAS  PubMed  Google Scholar 

Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A (2016) Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. JAMA Intern Med 176:175–183. https://doi.org/10.1001/jamainternmed.2015.7148

Article  PubMed  Google Scholar 

Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303:1815–1822. https://doi.org/10.1001/jama.2010.594

Article  CAS  PubMed  Google Scholar 

Ginde AA, Blatchford P, Breese K, Zarrabi L, Linnebur SA, Wallace JI, Schwartz RS (2017) High-dose monthly vitamin D for prevention of acute respiratory infection in older long-term care residents: a randomized clinical trial. J Am Geriatr Soc 65:496–503. https://doi.org/10.1111/jgs.14679

Article  PubMed  Google Scholar 

Michos ED, Kalyani RR, Blackford AL, Sternberg AL, Mitchell CM, Juraschek SP, Schrack JA, Wanigatunga AA, Roth DL, Christenson RH, Miller ER 3rd, Appel LJ (2022) The relationship of falls with achieved 25-hydroxyvitamin D levels from vitamin d supplementation: the sturdy trial. J Endocr Soc. 6:bvac065. https://doi.org/10.1210/jendso/bvac065

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zittermann A, Ernst JB, Prokop S, Fuchs U, Dreier J, Kuhn J, Knabbe C, Birschmann I, Schulz U, Berthold HK, Pilz S, Gouni-Berthold I, Gummert JF, Dittrich M, Börgermann J (2017) Effect of vitamin D on all-cause mortality in heart failure (EVITA): a 3-year randomized clinical trial with 4000 IU vitamin D daily. Eur Heart J 38:2279–2286. https://doi.org/10.1093/eurheartj/ehx235

Article  CAS  PubMed  Google Scholar 

Rooney MR, Harnack L, Michos ED, Ogilvie RP, Sempos CT, Lutsey PL (2017) Trends in use of high-dose vitamin D supplements exceeding 1000 or 4000 international units daily, 1999–2014. JAMA 317:2448–2450. https://doi.org/10.1001/jama.2017.4392

Article  PubMed  PubMed Central  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic rev and meta-analyses: the PRISMA statement. Ann Intern Med 151:264–269

Article  PubMed  Google Scholar 

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a metaanalysis. Stat Med 21:1539–1558. https://doi.org/10.1002/sim.1186

Article  PubMed  Google Scholar 

Macaskill P, Walter SD, Irwig L (2001) A comparison of methods to detect publication bias in meta-analysis. Stat Med 20:641–654. https://doi.org/10.1002/sim.698

Article  CAS  PubMed  Google Scholar 

Cochrane Community (beta). Cochrane handbook for systematic reviews of interventions. www.cochrane.org/handbook. Accessed Mar 2015.

Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL (2011) Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 26:2341–2357. https://doi.org/10.1002/jbmr.463

Article  CAS  PubMed  Google Scholar 

Gallagher JC, Sai A, Templin T 2nd, Smith L (2012) Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 156:425–437

Article  PubMed  Google Scholar 

Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Björkhem-Bergman L, Ekström L, LindhJD AJ (2012) Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open 2:e001663. https://doi.org/10.1136/bmjopen-2012-001663

Article  PubMed  PubMed Central  Google Scholar 

Belenchia AM, Tosh AK, Hillman LS, Peterson CA (2013) Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 97:774–781. https://doi.org/10.3945/ajcn.112.050013

Article  CAS  PubMed  Google Scholar 

Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA, LaForce C, Lazarus SC, Lemanske R, Lugogo N, Martin RJ, Mauger DT, Naureckas E, Peters SP, Phipatanakul W, Que LG, Sheshadri A, Smith L, Solway J, Sullivan-Vedder L, Sumino K, Wechsler ME, Wenzel S, White SR, Sutherland ER, Heart N, Lung, and Blood Institute’s AsthmaNet, (2014) Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA 311:2083–2091. https://doi.org/10.1001/jama.2014.5052

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arora P, Song Y, Dusek J, Plotnikoff G, Sabatine MS, Cheng S, Valcour A, Swales H, Taylor B, Carney E, Guanaga D, Young JR, Karol C, Torre M, Azzahir A, Strachan SM, O’Neill DC, Wolf M, Harrell F, Newton-Cheh C, Wang TJ (2015) Vitamin D therapy in individuals with prehypertension or hypertension: the DAYLIGHT trial. Circulation 131:254–262. https://doi.org/10.1161/CIRCULATIONAHA.114.011732

Article  CAS  PubMed  Google Scholar 

Garg G, Kachhawa G, Ramot R, Khadgawat R, Tandon N, Sreenivas V, Kriplani A, Gupta N (2015) Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study. Endocr Connect 4:108–116. https://doi.org/10.1530/EC-15-0001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muñoz-Aguirre P, Flores M, Macias N, Quezada AD, Denova-Gutiérrez E, Salmerón J (2015) The effect of vitamin D supplementation on serum lipids in postmenopausal women with diabetes: a randomized controlled trial. Clin Nutr 34:799–804. https://doi.org/10.1016/j.clnu.2014.10.002

Article  CAS  PubMed  Google Scholar 

Witte KK, Byrom R, Gierula J, Paton MF, Jamil HA, Lowry JE, Gillott RG, Barnes SA, Chumun H, Kearney LC, Greenwood JP, Plein S, Law GR, Pavitt S, Barth JH, Cubbon RM, Kearney MT (2016) Effects of vitamin D on cardiac function in patients with chronic HF: the VINDICATE study. J Am Coll Cardiol 67:2593–2603. https://doi.org/10.1016/j.jacc.2016.03.508

Article  CAS  PubMed  PubMed Central  Google Scholar 

Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O’Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST (2016) Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial. JAMA 315:362–370. https://doi.org/10.1001/jama.2015.18589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hin H, Tomson J, Newman C, Kurien R, Lay M, Cox J, Sayer J, Hill M, Emberson J, Armitage J, Clarke R (2017) Optimum dose of vitamin D for disease prevention in older people: BEST-D trial of vitamin D in rimary care. Osteoporos Int 28:841–851. https://doi.org/10.1007/s00198-016-3833-y

Article  CAS  PubMed  Google Scholar 

Björkhem-Bergman L, Missailidis C, Karlsson-Valik J, Tammelin A, Ekström L, Bottai M, Hammar U, Lindh G, Bergman P (2018) Vitamin D supplementation to persistent carriers of MRSA-a randomized and placebo-controlled clinical trial. Eur J Clin Microbiol Infect Dis 37:1735–1744. https://doi.org/10.1007/s10096-018-3306-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, Brodsky I, Ceglia L, Chadha C, Chatterjee R, Desouza C, Dolor R, Foreyt J, Fuss P, Ghazi A, Hsia DS, Johnson KC, Kashyap SR, Kim S, LeBlanc ES, Lewis MR, Liao E, Neff LM, Nelson J, O’Neil P, Park J, Peters A, Phillips LS, Pratley R, Raskin P, Rasouli N, Robbins D, Rosen C, Vickery EM, Staten M, D2d Research Group (2019) Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med 381:520–530. https://doi.org/10.1056/NEJMoa1900906

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forno E, Bacharier LB, Phipatanakul W, Guilbert TW, Cabana MD, Ross K, Covar R, Gern JE, Rosser FJ, Blatter J, Durrani S, Han YY, Wisniewski SR, Celedón JC (2020) Effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels: the VDKA randomized clinical trial. JAMA 324:752–760. https://doi.org/10.1001/jama.2020.12384

Article  CAS  PubMed  Google Scholar 

Billington EO, Burt LA, Rose MS, Davison EM, Gaudet S, Kan M, Boyd SK, Hanley DA (2020) Safety of high-dose vitamin D supplementation: secondary analysis of a randomized controlled trial. J Clin Endocrinol Metab 105:dgz212. https://doi.org/10.1210/clinem/dgz212

Article  PubMed  Google Scholar 

Nausheen S, Habib A, Bhura M, Rizvi A, Shaheen F, Begum K, Iqbal J, Ariff S, Shaikh L, Raza SS, Soofi SB (2021) Impact evaluation of the efficacy of different doses of vitamin D supplementation during pregnancy on pregnancy and birth outcomes: a randomised, controlled, dose comparison trial in Pakistan. BMJ Nutr Prev Health 4:425–434. https://doi.org/10.1136/bmjnph-2021-000304

Article  PubMed  PubMed Central  Google Scholar 

Tsujita M, Doi Y, Obi Y, Hamano T, Tomosugi T, Futamura K, Okada M, Hiramitsu T, Goto N, Isaka Y, Takeda A, Narumi S, Watarai Y (2022) Cholecalciferol supplementation attenuates bone loss in incident kidney transplant recipients: a prespecified secondary endpoint analysis of a randomized controlled trial. J Bone Miner Res 37:303–311. https://doi.org/10.1002/jbmr.4469

Article  CAS  PubMed  Google Scholar 

Doi Y, Tsujita M, Hamano T, Obi Y, Namba-Hamano T, Tomosugi T, Futamura K, Okada M, Hiramitsu T, Goto N, Nishiyama A, Takeda A, Narumi S, Watarai Y, Isaka Y (2021) The effect of cholecalciferol supplementation on allograft function in incident kidney transplant recipients: a randomized controlled study. Am J Transplant 21:3043–3054. https://doi.org/10.1111/ajt.16530

Article  CAS  PubMed 

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