Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33.
Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev. 2004;25:276–308.
Article CAS PubMed Google Scholar
Yuan X, Cai C, Chen S, Chen S, Yu Z, Balk SP. Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis. Oncogene. 2014;33:2815–25.
Article CAS PubMed Google Scholar
Heemers HV, Tindall DJ. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev. 2007;28:778–808.
Article CAS PubMed Google Scholar
Huggins C, Hodges CV. Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. J Urol. 2002;168:9–12.
Chamberlain LH, Shipston MJ. The physiology of protein S-acylation. Physiol Rev. 2015;95:341–76.
Article CAS PubMed PubMed Central Google Scholar
Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H. Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies. Chem Rev. 2018;118:919–88.
Article CAS PubMed PubMed Central Google Scholar
Zmuda F, Chamberlain LH. Regulatory effects of post-translational modifications on zDHHC S-acyltransferases. J Biol Chem. 2020;295:14640–52.
Article CAS PubMed PubMed Central Google Scholar
Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem. 2007;282:22278–88.
Article CAS PubMed Google Scholar
Yang X, Guo Z, Sun F, Li W, Alfano A, Shimelis H, et al. Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells. J Biol Chem. 2011;286:36152–60.
Article CAS PubMed PubMed Central Google Scholar
Zhou B, Liu L, Reddivari M, Zhang XA. The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. Cancer Res. 2004;64:7455–63.
Article CAS PubMed Google Scholar
Di Vizio D, Adam RM, Kim J, Kim R, Sotgia F, Williams T, et al. Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle. 2008;7:2257–67.
Article CAS PubMed Google Scholar
Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci USA. 2011;108:6579–84.
Article CAS PubMed PubMed Central Google Scholar
Kim S, Yang X, Yin A, Zha J, Beharry Z, Bai A, et al. Dietary palmitate cooperates with Src kinase to promote prostate tumor progression. Prostate. 2019;79:896–908.
Article CAS PubMed PubMed Central Google Scholar
Fiorentino M, Zadra G, Palescandolo E, Fedele G, Bailey D, Fiore C, et al. Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest. 2008;88:1340–8.
Article CAS PubMed PubMed Central Google Scholar
De Piano M, Manuelli V, Zadra G, Otte J, Edqvist PD, Ponten F, et al. Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. Oncogene. 2020;39:3666–79.
Article PubMed PubMed Central Google Scholar
Thomas R, Srivastava S, Katreddy RR, Sobieski J, Weihua Z. Kinase-inactivated EGFR is required for the survival of Wild-Type EGFR-expressing cancer cells treated with tyrosine kinase inhibitors. Int J Mol Sci. 2019;20:2515.
Article CAS PubMed PubMed Central Google Scholar
Ko PJ, Dixon SJ. Protein palmitoylation and cancer. EMBO Rep. 2018;19:e46666.
Article PubMed PubMed Central Google Scholar
Chen B, Zheng B, DeRan M, Jarugumilli GK, Fu J, Brooks YS, et al. ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity. Nat Chem Biol. 2016;12:686–93.
Article CAS PubMed PubMed Central Google Scholar
Pedram A, Razandi M, Deschenes RJ, Levin ER. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Mol Biol Cell. 2012;23:188–99.
Article CAS PubMed PubMed Central Google Scholar
Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, et al. Identification of ZDHHC14 as a novel human tumour suppressor gene. J Pathol. 2014;232:566–77.
Article CAS PubMed Google Scholar
Zhao JC, Yu J, Runkle C, Wu L, Hu M, Wu D, et al. Cooperation between Polycomb and androgen receptor during oncogenic transformation. Genome Res. 2012;22:322–31.
Article CAS PubMed PubMed Central Google Scholar
Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, et al. Towards a knowledge-based human protein Atlas. Nat Biotechnol. 2010;28:1248–50.
Article CAS PubMed Google Scholar
Rossin A, Durivault J, Chakhtoura-Feghali T, Lounnas N, Gagnoux-Palacios L, Hueber AO. Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. Cell Death Differ. 2015;22:643–53.
Article CAS PubMed Google Scholar
Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N. Engl J Med. 2014;371:1028–38.
Article PubMed PubMed Central Google Scholar
Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, Mostaghel EA, et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest. 2010;120:2715–30.
Article CAS PubMed PubMed Central Google Scholar
Xu D, Zhan Y, Qi Y, Cao B, Bai S, Xu W, et al. Androgen receptor splice variants dimerize to transactivate target genes. Cancer Res. 2015;75:3663–71.
Article CAS PubMed PubMed Central Google Scholar
Kim J, Lee Y, Lu X, Song B, Fong KW, Cao Q, et al. Polycomb- and methylation-independent roles of EZH2 as a transcription activator. Cell Rep. 2018;25:2808–20.e4.
Article CAS PubMed PubMed Central Google Scholar
Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell. 2010;17:443–54.
Article CAS PubMed PubMed Central Google Scholar
Jin HJ, Zhao JC, Wu L, Kim J, Yu J. Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program. Nat Commun. 2014;5:3972.
Article CAS PubMed Google Scholar
Xu B, Song B, Lu X, Kim J, Hu M, Zhao JC, et al. Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression. Cell Res. 2019;29:773–5.
Article PubMed PubMed Central Google Scholar
Lu X, Fong KW, Gritsina G, Wang F, Baca SC, Brea LT, et al. HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer. Nat Genet. 2022;54:670–83.
Article CAS PubMed PubMed Central Google Scholar
Fong KW, Zhao JC, Lu X, Kim J, Piunti A, Shilatifard A, et al. PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing. Mol Cell. 2022;82:4611–26.e7.
Article CAS PubMed Google Scholar
Park SH, Fong KW, Kim J, Wang F, Lu X, Lee Y, et al. Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer. Sci Adv. 2021;7:eabe2261.
Article CAS PubMed PubMed Central Google Scholar
Fong KW, Zhao JC, Song B, Zheng B, Yu J. TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression. Nat Commun. 2018;9:5007.
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