Ackar L, Casjens S, Andreas A et al. (2021) Blood-based detection of lung cancer using cysteine-rich angiogenic inducer 61 (CYR61) as a circulating protein biomarker: a pilot study. Mol Oncol 15:2877–2890. https://doi.org/10.1002/1878-0261.13099

Article  CAS  PubMed  Google Scholar 

Ahmed KA, Hasib TA, Paul SK et al. (2021) Potential role of CCN Proteins in breast cancer: therapeutic advances and perspectives. Curr Oncol 28:4972–4985. https://doi.org/10.3390/curroncol28060417

Article  PubMed  PubMed Central  Google Scholar 

Alami T, Liu J-L (2021) Metabolic effects of CCN5/WISP2 gene deficiency and transgenic overexpression in mice. Int J Mol Sci 22:13418. https://doi.org/10.3390/ijms222413418

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee SK, Banerjee S (2012) CCN5/WISP-2: a micromanager of breast cancer Progression. J Cell Commun Signal 6:63–71. https://doi.org/10.1007/s12079-012-0158-2

Article  PubMed  PubMed Central  Google Scholar 

Banerjee SK, Maity G, Haque I et al. (2016) human pancreatic cancer progression: an anarchy among CCN-siblings. J Cell Commun Signal 10:207–216. https://doi.org/10.1007/s12079-016-0343-9

Article  PubMed  PubMed Central  Google Scholar 

Barbe MF, Hilliard BA, Amin M et al. (2020) Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy. J Orthop Res 38:2396–2408. https://doi.org/10.1002/jor.24709

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbe MF, Amin M, Gingery A et al. (2021) Blocking CCN2 preferentially Inhibits osteoclastogenesis induced by repetitive high force bone loading. Connect Tiss Res 62:115–132. https://doi.org/10.1080/03008207.2020.1788546

Article  CAS  Google Scholar 

Barchetta I, Cimini FA, Capoccia D et al. (2017) WISP1 Is a marker of systemic and adipose tissue inflammation in dysmetabolic subjects with or without type 2 diabetes. J Endocrine Soc 1:660–670. https://doi.org/10.1210/js.2017-00108

Article  CAS  Google Scholar 

Bashir SM, Rather GA, Patrício A et al. (2022) Chitosan Nanoparticles: a versatile platform for biomedical applications. Materials 15:6521. https://doi.org/10.3390/ma15196521

Article  CAS  PubMed  PubMed Central  Google Scholar 

Betageri KR, Link PA, Haak AJ et al. (2023) The matricellular protein CCN3 supports lung endothelial homeostasis and function. Am J Physiol Lung Cell Mol Physiol 324:L154–L168. https://doi.org/10.1152/ajplung.00248.2022. (Epub 2022 Dec 27)

Article  CAS  PubMed  Google Scholar 

Bhat IP, Rather TB, Maqbool I et al. (2022) Connective tissue growth factor expression hints at aggressive nature of colorectal cancer. World J Gastroenterol 28:547–569. https://doi.org/10.3748/wjg.v28.i5.547

Article  CAS  PubMed  PubMed Central  Google Scholar 

Birch J, Gil J (2020) Senescence and the SASP: many therapeutic avenues. Genes Dev 34:1565–1576. https://doi.org/10.1101/gad.343129.120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Birkeness LB, Snigdha Banerjee S, Quadir M, Banerjee SK (2023) The role of CCNs in controlling cellular communication in the tumor microenvironment. J Cell Commun Signal 17:35–45. https://doi.org/10.1007/s12079-022-00682-2

Article  CAS  PubMed  Google Scholar 

Blokland KEC, Pouwels SD, Schuliga M, Knight DA, Burgess JK (2020) Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases. Clin Sci 134:2681–2706. https://doi.org/10.1042/CS20190893

Article  CAS  Google Scholar 

Brown BA, Connolly GM, Mill CEJ et al. (2019) Aging differentially modulates the Wnt pro-survival signaling pathways in vascular smooth muscle cells. Aging Cell 18:e12844. https://doi.org/10.1111/acel.12844

Article  CAS  PubMed  Google Scholar 

Butler GS, Connor AR, Sounni NE et al. (2017) Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2). Matrix Biol 59:23–38. https://doi.org/10.1016/j.matbio.2016.07.006

Article  CAS  PubMed  Google Scholar 

Chai K-X, Chen Y-Q, Fan P-L et al. (2018) The correlation of Cyr61, CTGF, and VEGF with polymyositis/dermatomyositis. Medicine 97:34. https://doi.org/10.1097/MD.0000000000011775

Chang Z, Dang T, Meng X, Chai J (2022) The Role of CCN1 in esophageal adenocarcinoma: What we have learned from the lab. Cancer Control 29:1–9. https://doi.org/10.1177/10732748221074734

Article  Google Scholar 

Chang A-C, Lin L-W, Chen Y-C et al. (2023) The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis. Internat J Biol Sci 19:760–771. https://doi.org/10.7150/ijbs.77495

Article  CAS  Google Scholar 

Crawford LJ, Irvine AE (2016) The role of the CCN family of proteins in blood cancers. J Cell Commun Signal 10:197–205. https://doi.org/10.1007/s12079-016-0342-x

Article  PubMed  PubMed Central  Google Scholar 

Das A, Dhar K, Maity G, Sarkar S, Ghosh A (2017) Deficiency of CCN5/WISP-2- driven program in breast cancer promotes cancer epithelial cells to mesenchymal stem cells and breast cancer growth. Sci Rep 7:1220. https://doi.org/10.1038/s41598-017-00916-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das A, Haque I, Ray P et al (2021) CCN5 activation by free or encapsulated EGCG is required to render triple-negative breast cancer cell viability and tumor progression. Pharmacol Res Perspect 9:e00753. https://doi.org/10.1002/prp2.753

Davies SR, Davies ML, Sanders A et al. (2010) Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. Int J Oncol 36:1129–36. https://doi.org/10.3892/ijo_00000595

Article  CAS  PubMed  Google Scholar 

Deng W, Fernandez A, McLaughlin SL et al. (2020) Cell Communication Network Factor 4 (CCN4/WISP1) shifts melanoma cells from a fragile proliferative state to a resilient metastatic state. Cell Mol Bioeng 13:45–60. https://doi.org/10.1007/s12195-019-00602-2

Article  CAS  PubMed  Google Scholar 

Di Micco R, Krizhanovsky V, Baker D, di Fagagna D (2021) Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Cell Biol 22:75–95. https://doi.org/10.1038/s41580-020-00314-w

Article  CAS  Google Scholar 

Djomehri SI, Burman B, Gonzalez ME, Takayama S, Kleer CG (2019) A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer. J Cell Commun Signal 13:129–143. https://doi.org/10.1007/s12079-018-0498-7

Article  PubMed  Google Scholar 

Djomehri SI, Gonzalez ME, Leprevost FV et al. (2020) Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors. Nat Commun 11:1723. https://doi.org/10.1038/s41467-020-15283-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eguchi T, Okusha Y, Lu Y et al. (2023) Comprehensive method for exosome isolation and proteome analysis for detection of CCN factors in/on exosomes. Methods Mol Biol 2582:59–75. https://doi.org/10.1007/978-1-0716-2744

Article  PubMed  Google Scholar 

Ersoy GS, Ensari TA, Subas S et al. (2017) (2017) WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus. J Matern Fetal Neonatal Med 30:942–946. https://doi.org/10.1080/14767058.2016.1192118

Article  CAS  Google Scholar 

Esaily HA, Serag DM, Rizk MS et al. (2021) Relationship between cellular communication network factor 1 (CCN1) and carotid atherosclerosis in patients with rheumatoid arthritis. Med J Malaysia 76:311–317 (PMID: 3403132)

CAS  PubMed  Google Scholar 

Espinoza I, Yang L, Steen TV, et al. (2022) Binding of the angiogenic/senescence inducer CCN1/CYR61 to integrin α6β1 drives endocrine resistance in breast cancer cells. Aging 14(1200–1213):2022

Fang F, Zhao W-Y, Li R-K et al. (2014) Silencing of WISP3 suppresses gastric cancer cell proliferation and metastasis and inhibits Wnt/βcatenin signalling. Int J Clin Exp Pathol 7:6447–6461. PMCID: 25400723 PMCID: PMC4230117

Feng T, Meng J, Kou S et al. (2019) CCN1-induced cellular senescence promotes heart regeneration. Circ 139:2495–2498. https://doi.org/10.1161/CIRCULATIONAHA.119.039530

Article  Google Scholar 

Ferrand NF, Béreziat V, Moldes M et al. (2017) WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARγ activity. Sci Rep 7:1749. https://doi.org/10.1038/s41598-017-01866-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrand N, Fert A, Morichon R et al. (2022) WISP2/CCN5 suppresses vasculogenic mimicry through inhibition of YAP/TAZ signaling in breast cancer cells. Cancers 14:1487. https://doi.org/10.3390/cancers14061487

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandez-Ruiz R, García-Alamán A, Esteban Y et al. (2020) Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells. Nat Commun 11:5982. https://doi.org/10.1038/s41467-020-19657-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandez A, Deng W, McLaughlin SL et al. (2022) Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma. EMBO Rept 23:e54127. https://doi.org/10.15252/embr.202154127

Article  CAS  Google Scholar 

Fiaturi N, Russo JW, Nielsen HC, Castellot JJ Jr (2018) CCN5 in alveolar epithelial proliferation and differentiation during neonatal lung oxygen injury. J Cell Commun Signal 12:217–229. https://doi.org/10.1007/s12079-017-0443-1

Article  PubMed  PubMed Central  Google Scholar 

Fritah A, Saucier C, De Wever O et al. (2008) Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells. Mol Cell Biol 28:1114–1123. https://doi.org/10.1128/MCB.01335-07

Article  CAS  PubMed  Google Scholar 

Fu M, Peng D, L