Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy

Keywords

Super resolution microscopy

dSTORM

Deep learning

Nerve biopsies

Polyneuropathy

Node of Ranvier

Axoglial complex

Caspr-1

Neurofascin

Cytoskeleton

AbbreviationsCaspr-1

Contactin-1 associated protein 1

dSTORM

direct stochastic optical reconstruction microscopy

STED

Stimulated Emission Depletion

Data availability

The datasets supporting the conclusions of this article are included within the article and its supplemental files, or are available here: https://doi.org/10.5281/zenodo.6387772. Further raw data including original photomicrographs and simulations will be available upon request by any qualified researcher.

© 2023 The Author(s). Published by Elsevier Inc.

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