Mariani, J. & Vaccarino, F. M. Breakthrough moments: Yoshiki Sasai’s discoveries in the third dimension. Cell Stem Cell 24, 837–838 (2019).
Article CAS PubMed Central PubMed Google Scholar
Giandomenico, S. L., Sutcliffe, M. & Lancaster, M. A. Generation and long-term culture of advanced cerebral organoids for studying later stages of neural development. Nat. Protoc. 16, 579–602 (2021).
Article CAS PubMed Google Scholar
Bergmann, S. et al. Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics. Nat. Protoc. 13, 2827–2843 (2018).
Article CAS PubMed Central PubMed Google Scholar
Gabriel, E. et al. CPAP promotes timely cilium disassembly to maintain neural progenitor pool. EMBO J. 35, 803–819 (2016).
Article CAS PubMed Central PubMed Google Scholar
Gabriel, E. et al. Human brain organoids assemble functionally integrated bilateral optic vesicles. Cell Stem Cell 28, 1740–1757.e8 (2021).
Article CAS PubMed Google Scholar
Gopalakrishnan, J. The emergence of stem cell-based brain organoids: trends and challenges. BioEssays 41, e1900011 (2019).
Ramani, A. et al. SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO J. 39, e106230 (2020).
Article CAS PubMed Central PubMed Google Scholar
Sloan, S. A., Andersen, J., Pașca, A. M., Birey, F. & Pașca, S. P. Generation and assembly of human brain region-specific three-dimensional cultures. Nat. Protoc. 13, 2062–2085 (2018).
Article CAS PubMed Central PubMed Google Scholar
Quadrato, G. et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature 545, 48–53 (2017).
Article CAS PubMed Central PubMed Google Scholar
Goranci-Buzhala, G. et al. Rapid and efficient invasion assay of glioblastoma in human brain organoids. Cell Rep. 31, 107738 (2020).
Article CAS PubMed Google Scholar
Birey, F. et al. Assembly of functionally integrated human forebrain spheroids. Nature 545, 54–59 (2017).
Article CAS PubMed Central PubMed Google Scholar
Huschke, E. Uber einige streitpunkte aus der anatomie des auges [German]. Z. Opthalmol. 4, 273–295 (1835).
Pander, H. Beiträge zur Entwickelungsgeschichte des Hühnchens im Eye [German] (1817).
Adelmann, H. Marcello Malpighi and the Evolution of Embryology Vol. 3 (Cornell Univ. Press, 1966).
Zhong, X. et al. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat. Commun. 5, 4047 (2014).
Article CAS PubMed Google Scholar
Capowski, E. E. et al. Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines. Development 146, dev171686 (2019).
PubMed Central PubMed Google Scholar
Nakano, T. et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 10, 771–785 (2012).
Article CAS PubMed Google Scholar
Cowan, C. S. et al. Cell types of the human retina and its organoids at single-cell resolution. Cell 182, 1623–1640.e34 (2020).
Article CAS PubMed Central PubMed Google Scholar
Vergara, M. N. et al. Three-dimensional automated reporter quantification (3D-ARQ) technology enables quantitative screening in retinal organoids. Development 144, 3698–3705 (2017).
CAS PubMed Central PubMed Google Scholar
Meyer, J. S. et al. Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells 29, 1206–1218 (2011).
Article CAS PubMed Google Scholar
Eldred, K. C. et al. Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science 362, eaau6348 (2018).
Article PubMed Central PubMed Google Scholar
Eldred, K. C. & Reh, T. A. Human retinal model systems: strengths, weaknesses, and future directions. Dev. Biol. 480, 114–122 (2021).
Article CAS PubMed Google Scholar
Fligor, C. M. et al. Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids. Stem Cell Rep. 16, 2228–2241 (2021).
Graw, J. Eye development. Curr. Top. Dev. Biol. 90, 343–386 (2010).
Rao, R. C., Stern, J. H. & Temple, S. The eyeball’s connected to the brain ball. Cell Stem Cell 28, 1675–1677 (2021).
Article CAS PubMed Google Scholar
Fuhrmann, S. Eye morphogenesis and patterning of the optic vesicle. Curr. Top. Dev. Biol. 93, 61–84 (2010).
Article PubMed Central PubMed Google Scholar
Adler, R. & Canto-Soler, M. V. Molecular mechanisms of optic vesicle development: complexities, ambiguities and controversies. Dev. Biol. 305, 1–13 (2007).
Article CAS PubMed Central PubMed Google Scholar
Dupacova, N., Antosova, B., Paces, J. & Kozmik, Z. Meis homeobox genes control progenitor competence in the retina. Proc. Natl Acad. Sci. USA 118, e2013136118 (2021).
Article CAS PubMed Central PubMed Google Scholar
Mann, I. C. The Development of the Human Eye 1st edn (Univ. Press, 1928).
O’Rahilly, R. The early development of the eye in staged human embryos. Contrib. Embryol. 38, 1–42 (1966).
O’Rahilly, R. The prenatal development of the human eye. Exp. Eye Res. 21, 93–112 (1975).
Gabriel, E. & Gopalakrishnan, J. Generation of iPSC-derived human brain organoids to model early neurodevelopmental disorders. J. Vis. Exp. 14, 55372 (2017).
Gabriel, E. et al. Recent zika virus isolates induce premature differentiation of neural progenitors in human brain organoids. Cell. Stem Cell. 20, 397–406.e5 (2017).
Article CAS PubMed Google Scholar
Zhang, W. et al. Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Nat. Commun. 10, 2612 (2019).
Article PubMed Central PubMed Google Scholar
Rosen, D. & Mahabadi, N. Embryology, Optic Cup (StatPearls Publishing LLC, updated 8 May 2022); https://www.ncbi.nlm.nih.gov/books/NBK545150/
Cvekl, A. & Wang, W. L. Retinoic acid signaling in mammalian eye development. Exp. Eye Res. 89, 280–291 (2009).
Article CAS PubMed Central PubMed Google Scholar
Janesick, A., Wu, S. C. & Blumberg, B. Retinoic acid signaling and neuronal differentiation. Cell. Mol. Life Sci. 72, 1559–1576 (2015).
Article CAS PubMed Google Scholar
Morizane, A., Doi, D., Kikuchi, T., Nishimura, K. & Takahashi, J. Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells. J. Neurosci. Res. 89, 117–126 (2011).
Article CAS PubMed Google Scholar
Jin, M., Yuan, Q., Li, S. & Travis, G. H. Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65. J. Biol. Chem. 282, 20915–20924 (2007).
Article CAS PubMed Google Scholar
Hu, J. & Bok, D. The use of cultured human fetal retinal pigment epithelium in studies of the classical retinoid visual cycle and retinoid-based disease processes. Exp. Eye Res. 126, 46–50 (2014).
Article CAS PubMed Google Scholar
Francis, P. J. Genetics of inherited retinal disease. J. R. Soc. Med. 99, 189–191 (2006).
Article PubMed Central PubMed Google Scholar
Takagi, S. et al. Evaluation of transplanted autologous induced pluripotent stem cell-derived retinal pigment epithelium in exudative age-related macular degeneration. Ophthalmol. Retin. 3, 850–859 (2019).
Dahl-Jensen, S. & Grapin-Botton, A. The physics of organoids: a biophysical approach to understanding organogenesis. Development 144, 946–951 (2017).
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