Bloom GS. Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 2014;71:505–8.
Latimer CS, Stair JG, Hincks JC, Currey HN, Bird TD, Keene CD, et al. TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans. Dis Models Mechanisms. 2022;15:dmm049323.
Larkin HD, Lecanemab, Gains FDA. Approval for Early Alzheimer Disease. JAMA. 2023;329:363.
Arndt JW, Qian F, Smith BA, Quan C, Kilambi KP, Bush MW, et al. Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. Sci Rep. 2018;8:6412.
Article PubMed PubMed Central Google Scholar
Salloway S, Chalkias S, Barkhof F, Burkett P, Barakos J, Purcell D, et al. Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease. JAMA Neurol. 2022;79:13–21.
Catania M, Giaccone G, Salmona M, Tagliavini F, Di Fede G. Dreaming of a New World Where Alzheimer’s Is a Treatable Disorder. Front Aging Neurosci. 2019;11:317–24.
Sharma P, Srivastava P, Seth A, Tripathi PN, Banerjee AG, Shrivastava SK. Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies. Prog Neurobiol. 2019;174:53–89.
Article CAS PubMed Google Scholar
Mehta D, Jackson R, Paul G, Shi J, Sabbagh M. Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015. Expert Opin Investig Drugs. 2017;26:735–9.
Article CAS PubMed PubMed Central Google Scholar
Cacabelos R. Have there been improvements in Alzheimer’s disease drug discovery over the past 5 years? Expert Opin Drug Discov. 2018;13:523–38.
Article CAS PubMed Google Scholar
Cummings JL, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther. 2014;6:37.
Article PubMed PubMed Central Google Scholar
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science. 2002;297:353–6.
Article CAS PubMed Google Scholar
Imbimbo BP, Ippati S, Watling M, Balducci C. A critical appraisal of tau-targeting therapies for primary and secondary tauopathies. Alzheimer’s Dement. 2022;18:1008–37.
Jadhav S, Avila J, Schöll M, Kovacs GG, Kövari E, Skrabana R, et al. A walk through tau therapeutic strategies. Acta Neuropathologica Commun. 2019;7:22.
Di Fede G, Catania M, Morbin M, Rossi G, Suardi S, Mazzoleni G, et al. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. Science. 2009;323:1473–7.
Article PubMed PubMed Central Google Scholar
Cantu’ L, Colombo L, Stoilova T, Demé B, Inouye H, Booth R, et al. The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study. Sci Rep. 2017;7:5510.
Article PubMed PubMed Central Google Scholar
Catania M, Colombo L, Sorrentino S, Cagnotto A, Lucchetti J, Barbagallo MC, et al. A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease. Mol Psychiatry. 2022. https://doi.org/10.1038/s41380-022-01745-x.
Di Fede G, Catania M, Morbin M, Giaccone G, Moro ML, Ghidoni R, et al. Good gene, bad gene: new APP variant may be both. Prog Neurobiol. 2012;99:281–92.
Diomede L, Romeo M, Cagnotto A, Rossi A, Beeg M, Stravalaci M, et al. The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity. Neurobiol Dis. 2016;88:75–84.
Article CAS PubMed Google Scholar
Messa M, Colombo L, del Favero E, Cantù L, Stoilova T, Cagnotto A, et al. The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly. J Biol Chem. 2014;289:24143–52.
Article CAS PubMed PubMed Central Google Scholar
Diomede L, Di Fede G, Romeo M, Bagnati R, Ghidoni R, Fiordaliso F, et al. Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity. Neurobiol Dis. 2014;62:521–32.
Article CAS PubMed PubMed Central Google Scholar
Cimini S, Sclip A, Mancini S, Colombo L, Messa M, Cagnotto A, et al. The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt. Neurobiol Dis. 2016;89:101–11.
Article CAS PubMed Google Scholar
Di Fede G, Catania M, Maderna E, Morbin M, Moda F, Colombo L, et al. Tackling amyloidogenesis in Alzheimer’s disease with A2V variants of Amyloid-β. Sci Rep. 2016;6:20949.
Article PubMed PubMed Central Google Scholar
Maloney JA, Bainbridge T, Gustafson A, Zhang S, Kyauk R, Steiner P, et al. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein. J Biol Chem. 2014;289:30990–31000.
Article CAS PubMed PubMed Central Google Scholar
Benilova I, Gallardo R, Ungureanu A-A, Castillo Cano V, Snellinx A, Ramakers M, et al. The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation. J Biol Chem. 2014;289:30977–89.
Article CAS PubMed PubMed Central Google Scholar
Natale C, Barzago MM, Diomede L. Caenorhabditis elegans Models to Investigate the Mechanisms Underlying Tau Toxicity in Tauopathies. Brain Sci. 2020;10:E838.
Zanier ER, Barzago MM, Vegliante G, Romeo M, Restelli E, Bertani I, et al. C. elegans detects toxicity of traumatic brain injury generated tau. Neurobiol Dis. 2021;153:105330.
Article CAS PubMed PubMed Central Google Scholar
Natale C, Barzago MM, Colnaghi L, De Luigi A, Orsini F, Fioriti L, et al. A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo. Int J Mol Sci. 2022;23:11277.
Article CAS PubMed PubMed Central Google Scholar
Zanier ER, Bertani I, Sammali E, Pischiutta F, Chiaravalloti MA, Vegliante G, et al. Induction of a transmissible tau pathology by traumatic brain injury. Brain. 2018;141:2685–99.
PubMed PubMed Central Google Scholar
Risling M, Smith D, Stein TD, Thelin EP, Zanier ER, Ankarcrona M, et al. Modelling human pathology of traumatic brain injury in animal models. J Intern Med. 2019;285:594–607.
Article CAS PubMed PubMed Central Google Scholar
Schmidt ML, Zhukareva V, Newell KL, Lee VM, Trojanowski JQ. Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer’s disease. Acta Neuropathol. 2001;101:518–24.
Article CAS PubMed Google Scholar
Agrawal S, Leurgans SE, James BD, Barnes LL, Mehta RI, Dams-O’Connor K, et al. Association of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons. JAMA Netw Open. 2022;5:e229311.
Article PubMed PubMed Central Google Scholar
Shively S, Scher AI, Perl DP, Diaz-Arrastia R. Dementia resulting from traumatic brain injury: what is the pathology? Arch Neurol. 2012;69:1245–51.
Article PubMed PubMed Central Google Scholar
Li Y, Li Y, Li X, Zhang S, Zhao J, Zhu X, et al. Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies. PLoS One. 2017;12:e0169650.
Article PubMed PubMed Central Google Scholar
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003;39:409–21.
Article CAS PubMed Google Scholar
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharm Pharmacother. 2010;1:94–99.
Moro F, Fossi F, Magliocca A, Pascente R, Sammali E, Baldini F, et al. Efficacy of acute administration of inhaled argon on traumatic brain injury in mice. Br J Anaesth. 2021;126:256–64.
Article CAS PubMed Google Scholar
Moro F, Pischiutta F, Portet A, Needham EJ, Norton EJ, Ferdinand JR, et al. Ageing is associated with maladaptive immune response and worse outcome after traumatic brain injury. Brain Commun. 2022;4:fcac036.
Article PubMed PubMed Central Google Scholar
Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, et al. Electromagnetic Controlled Cortical Impact Device for Precise, Graded Experimental Traumatic Brain Injury. J Neurotrauma. 2007;24:657–73.
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