Current standard of care for people using oral HIV-pre-exposure prophylaxis (PrEP) involves face-to-face clinic appointments for HIV, syphilis, gonorrhoea and chlamydia (STI) testing every 3 months.1 Providing more convenient clinical pathways can help optimise HIV-PrEP as a prevention strategy.2 PrEP-EmERGE is an mHealth application (app) and digital pathway co-designed by users and clinicians to support and empower people using HIV-PrEP, and reduce the number of face-to-face clinic appointments.3 PrEP-EmERGE aims to support people using HIV-PrEP by providing users with secure access to their results (recent and historic), a diary function with medication reminders, vaccination history, details of upcoming appointments and a messaging system which facilitates communication from the clinic to the end user.3 We invite existing HIV-PrEP users who use a personal smartphone, do not require interventions for drug/alcohol dependence, have not previously had syphilis, and have completed hepatitis A, hepatitis B and human papilloma virus vaccinations to use PrEP-EmERGE. Starting in August 2021, as part of each …