This study was funded by Alnylam Pharmaceuticals. VA Clausen, JM Gansner, GJ Robbie and J Wu are employees of Alnylam Pharmaceuticals and are shareholders or hold stock options from Alnylam Pharmaceuticals. KH Cao is a former employee of Alnylam Pharmaceuticals and is a shareholder of Alnylam Pharmaceuticals. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Medical writing and editorial assistance were provided by Peloton Advantage, LLC, an OPEN Health company, in accordance with Good Publication Practice (GPP3) guidelines, and funded by Alnylam Pharmaceuticals.