The underlying causes of splenomegaly are myriad and include acute, chronic and tropical infections; haematological malignancies (both acute and chronic, myeloid and lymphoid); non-neoplastic haematological conditions (thalassaemia, autoimmune haemolysis); congestive causes (cirrhosis, cardiac failure); inflammatory conditions (systemic lupus erythematosus, sarcoidosis); neoplastic causes (haemangioma, metastases) and infiltrative processes (Gaucher’s disease, amyloidosis).1 Chronic myeloid leukaemia (CML) is a haematopoietic stem cell–derived myeloproliferative neoplasm, molecularly characterised by the presence of the BCR::ABL1 oncogene and which has become the paradigm for molecularly targeted therapy in oncology. The common …