Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.

Article  PubMed  Google Scholar 

Erratum. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2020;70:313.

Article  Google Scholar 

Engstrand J, Nilsson H, Strömberg C, Jonas E, Freedman J. Colorectal cancer liver metastases - a population-based study on incidence, management and survival. BMC Cancer. 2018;18:78.

Article  PubMed  PubMed Central  Google Scholar 

Cusack B, Buggy DJ. Anaesthesia, analgesia, and the surgical stress response. BJA Educ. 2020;20:321–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gottschalk A, Sharma S, Ford J, Durieux ME, Tiouririne M. Review article: the role of the perioperative period in recurrence after cancer surgery. Anesth Analg. 2010;110:1636–43.

Article  PubMed  Google Scholar 

Marik PE, Flemmer M. The immune response to surgery and trauma: implications for treatment. J Trauma Acute Care Surg. 2012;73:801–8.

Article  CAS  PubMed  Google Scholar 

Lundy J, Ford CM. Surgery, trauma and immune suppression. Evolving the mechanism. Ann Surg. 1983;197:434–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kishton RJ, Sukumar M, Restifo NP. Metabolic regulation of T cell longevity and function in Tumor Immunotherapy. Cell Metab. 2017;26:94–109.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000;85:109–17.

Article  CAS  PubMed  Google Scholar 

Ouyang R, Ren H, Liu W, Yuan X, Lei E. Remifentanil inhibits the traumatic stress response in emergent trauma surgery. J Clin Lab Anal. 2019;33:e22971.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sayed S, Idriss NK, Sayyedf HG, Ashry AA, Rafatt DM, Mohamed AO, et al. Effects of propofol and isoflurane on haemodynamics and the inflammatory response in cardiopulmonary bypass surgery. Br J Biomed Sci. 2015;72:93–101.

Article  CAS  PubMed  Google Scholar 

Punjasawadwong Y, Phongchiewboon A, Bunchungmongkol N. Bispectral index for improving anaesthetic delivery and postoperative recovery. Cochrane Database Syst Rev. 2014;2014:Cd003843.

PubMed  PubMed Central  Google Scholar 

Tímár J, Ladányi A, Forster-Horváth C, Lukits J, Döme B, Remenár E, et al. Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CD4/CD8 ratio and tumor microenvironment: a multicenter phase II clinical trial. J Clin Oncol. 2005;23:3421–32.

Article  PubMed  Google Scholar 

Hori Y, Ibuki T, Hosokawa T, Tanaka Y. The effects of neurosurgical stress on peripheral lymphocyte subpopulations. J Clin Anesth. 2003;15:1–8.

Article  PubMed  Google Scholar 

Johansen JW, Sebel PS. Development and clinical application of electroencephalographic bispectrum monitoring. Anesthesiology. 2000;93:1336–44.

Article  CAS  PubMed  Google Scholar 

Short TG, Campbell D, Frampton C, Chan MTV, Myles PS, Corcoran TB, et al. Anaesthetic depth and complications after major surgery: an international, randomised controlled trial. Lancet. 2019;394:1907–14.

Article  PubMed  Google Scholar 

Kertai MD, Palanca BJ, Pal N, Burnside BA, Zhang L, Sadiq F, et al. Bispectral index monitoring, duration of bispectral index below 45, patient risk factors, and intermediate-term mortality after noncardiac surgery in the B-Unaware trial. Anesthesiology. 2011;114:545–56.

Article  PubMed  Google Scholar 

Stephenson C, Mohabbat A, Raslau D, Gilman E, Wight E, Kashiwagi D. Management of Common Postoperative Complications. Mayo Clin Proc. 2020;95:2540–2554.

Seidelman J, Anderson DJ. Surgical Site Infections. Infect Dis Clin North Am. 2021;35:901–29.

Article  PubMed  Google Scholar 

Farah K, Lubiato A, Meyer M, Prost S, Ognard J, Blondel B, et al. Surgical site infection following surgery for spinal deformity: about 102 patients. Neurochirurgie. 2021;67:152–6.

Article  CAS  PubMed  Google Scholar 

Liu S, Gu X, Zhu L, Wu G, Zhou H, Song Y, et al. Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer. Med (Baltim). 2016;95:e5479.

Article  CAS  Google Scholar 

Faisal M, Schäfer CN, Myrelid P, Winberg ME, Söderholm JD, Keita ÃV, et al. Effects of analgesic and surgical modality on immune response in colorectal cancer surgery. Surg Oncol. 2021;38:101602.

Article  PubMed  Google Scholar 

Nagasaka H, Ohno S, Kobayashi K, Sakagami H. [Effect of anesthetics on malignant tumor cells (a review)]. Masui. 2009;58:1216–25.

PubMed  Google Scholar 

Samir A, Gandreti N, Madhere M, Khan A, Brown M, Loomba V. Anti-inflammatory effects of propofol during cardiopulmonary bypass: a pilot study. Ann Card Anaesth. 2015;18:495–501.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwasaki M, Edmondson M, Sakamoto A, Ma D. Anesthesia, surgical stress, and “long-term” outcomes. Acta Anaesthesiol Taiwan. 2015;53:99–104.

Article  PubMed  Google Scholar 

Walker JJ, Terry JR, Lightman SL. Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis. Proc Biol Sci. 2010;277:1627–33.

CAS  PubMed  PubMed Central  Google Scholar 

Yang LQ, Li JJ, Chen SQ, Wang YW. Effect of different depths of anesthesia on perioperative stress response in children undergoing adenoidectomy and tonsillectomy. CNS Neurosci Ther. 2013;19:134–5.

Article  CAS  PubMed  Google Scholar 

Quan C, Chen J, Luo Y, Zhou L, He X, Liao Y, et al. BIS-guided deep anesthesia decreases short-term postoperative cognitive dysfunction and peripheral inflammation in elderly patients undergoing abdominal surgery. Brain Behav. 2019;9:e01238.

Article  PubMed  PubMed Central  Google Scholar 

Park JH, McMillan DC, Horgan PG, Roxburgh CS. The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer. Cancer Treat Rev. 2014;40:68–77.

Article  CAS  PubMed  Google Scholar 

Diederichsen AC, Hjelmborg J, Christensen PB, Zeuthen J, Fenger C. Prognostic value of the CD4+/CD8 + ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells. Cancer Immunol Immunother. 2003;52:423–8.

Article  CAS  PubMed  Google Scholar 

Kamphorst AO, Ahmed R. CD4 T-cell immunotherapy for chronic viral infections and cancer. Immunotherapy. 2013;5:975–87.

Article  CAS  PubMed  Google Scholar 

Brittenden J, Heys SD, Ross J, Eremin O. Natural killer cells and cancer. Cancer. 1996;77:1226–43.

Article  CAS  PubMed  Google Scholar 

Angka L, Martel AB, Kilgour M, Jeong A, Sadiq M, de Souza CT, et al. Natural killer cell IFNγ secretion is profoundly suppressed following colorectal Cancer surgery. Ann Surg Oncol. 2018;25:3747–54.

Article  PubMed  Google Scholar 

Cho JS, Kim NY, Shim JK, Jun JH, Lee S, Kwak YL. The immunomodulatory effect of ketamine in colorectal cancer surgery: a randomized-controlled trial. Can J Anaesth. 2021;68:683–92.

Article  CAS  PubMed  Google Scholar 

Juneja R. Opioids and cancer recurrence. Curr Opin Support Palliat Care. 2014;8:91–101.

Article  PubMed  Google Scholar 

Fujioka N, Nguyen J, Chen C, Li Y, Pasrija T, Niehans G, et al. Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer. Anesth Analg. 2011;113:1353–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watt DG, Horgan PG, McMillan DC. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review. Surgery. 2015;157:362–80.

Article  PubMed  Google Scholar 

Amodeo G, Bugada D, Franchi S, Moschetti G, Grimaldi S, Panerai A, et al. Immune function after major surgical interventions: the effect of postoperative pain treatment. J Pain Res. 2018;11:1297–305.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canavese M, Ngo DT, Maddern GJ, Hardingham JE, Price TJ, Hauben E. Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer. Int J Cancer. 2017;140:2183–91.

Article  CAS