aDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States. Moutal is now with the Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, United States

bDepartment of Neurology, Mayo Clinic, Phoenix, AZ, United States

cDepartment of Pharmacology and Neuroscience and Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States

*Corresponding author. Address: Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, United States. Tel.: +1 (520) 626-4381. E-mail address: [email protected] (E. Navratilova).

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

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C. M. Kopruszinski and M. Watanabe contributed equally.