Departments of aMedicine and

bAnesthesiology, University of California, San Diego, La Jolla, CA, United States

cSchool of Neuroscience, Virginia Polytechnic and State University, Blacksburg, VA, United States

dDepartments of Anesthesia and Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States

*Corresponding author. Address: University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States. Tel.: +1-858-822-5771. E-mail address: [email protected] (Y. I. Miller).

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