Tiek DM, Erdogdu B, Razaghi R, Jin L, Sadowski N, Alamillo-Ferrer C, et al. Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas. Sci Adv. 2022;8:eabn3471.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014-8. Neuro Oncol. 2021;23:iii1–iii105.

Article  PubMed  PubMed Central  Google Scholar 

Nizamutdinov D, Stock EM, Dandashi JA, Vasquez EA, Mao Y, Dayawansa S, et al. Prognostication of survival outcomes in patients diagnosed with glioblastoma. World Neurosurg. 2018;109:e67–74.

Article  PubMed  Google Scholar 

Messaoudi K, Clavreul A, Lagarce F. Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide. Drug Discov Today. 2015;20:899–905.

Article  CAS  PubMed  Google Scholar 

Mannas JP, Lightner DD, Defrates SR, Pittman T, Villano JL. Long-term treatment with temozolomide in malignant glioma. J Clin Neurosci. 2014;21:121–3.

Article  CAS  PubMed  Google Scholar 

de Souza I, Monteiro LKS, Guedes CB, Silva MM, Andrade-Tomaz M, Contieri B, et al. High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation. Cell Death Dis. 2022;13:591.

Article  PubMed  PubMed Central  Google Scholar 

Wei J, Wang Z, Wang W, Liu X, Wan J, Yuan Y, et al. Oxidative stress activated by sorafenib alters the temozolomide sensitivity of human glioma cells through autophagy and JAK2/STAT3-AIF axis. Front Cell Dev Biol. 2021;9:660005.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Liu K, Huang Y, Sun M, Tian Q, Zhang S, et al. TRIM25 promotes TNF-alpha-induced NF-kappaB activation through potentiating the K63-linked ubiquitination of TRAF2. J Immunol. 2020;204:1499–507.

Article  CAS  PubMed  Google Scholar 

Zhou S, Peng J, Xiao L, Zhou C, Fang Y, Ou Q, et al. TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability. Cell Death Dis. 2021;12:463.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei P, Xie F, Pan J, Wang S, Gao W, Ge R, et al. E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis. Cell Death Differ. 2021;28:2888–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, et al. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Nat Commun. 2020;11:348.

Article  PubMed  PubMed Central  Google Scholar 

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Z, Zhang KN, Wang Q, Li G, Zeng F, Zhang Y, et al. Chinese Glioma Genome Atlas (CGGA): a comprehensive resource with functional genomic data from Chinese glioma patients. Genomics Proteomics Bioinformatics. 2021;19:1–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He C, Lu S, Wang XZ, Wang CC, Wang L, Liang SP, et al. FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy. Acta Pharmacol Sin. 2021;42:1324–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan P, Xie XH, Chen CH, Peng X, Zhang P, Yang C, et al. Molecular regulation mechanisms and interactions between reactive oxygen species and mitophagy. DNA Cell Biol. 2019;38:10–22.

Article  CAS  PubMed  Google Scholar 

Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, et al. Role of mitochondria in ferroptosis. Mol Cell. 2019;73:354–63.e3.

Article  CAS  PubMed  Google Scholar 

Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol. 2021;220:e202105043.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng C, Zhan J, Chen D, Shao G, Zhang H, Gu W, et al. The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2. Oncogene. 2021;40:1706–20.

Article  CAS  PubMed  Google Scholar 

Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63:173–84.

Article  CAS  PubMed  Google Scholar 

Roh JL, Kim EH, Jang H, Shin D. Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis. Redox Biol. 2017;11:254–62.

Article  CAS  PubMed  Google Scholar 

Hatakeyama S. TRIM proteins and cancer. Nat Rev Cancer. 2011;11:792–804.

Article  CAS  PubMed  Google Scholar 

Chen L, Yang X. TRIM11 cooperates with HSF1 to suppress the anti-tumor effect of proteotoxic stress drugs. Cell Cycle. 2019;18:60–8.

Article  CAS  PubMed  Google Scholar 

Chen L, Brewer MD, Guo L, Wang R, Jiang P, Yang X. Enhanced degradation of misfolded proteins promotes tumorigenesis. Cell Rep. 2017;18:3143–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biol. 2013;1:45–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei JW, Cui JQ, Zhou X, Fang C, Tan YL, Chen LY, et al. F25P preproinsulin abrogates the secretion of pro-growth factors from EGFRvIII cells and suppresses tumor growth in an EGFRvIII/wt heterogenic model. Cancer Lett. 2016;380:1–9.

Article  CAS  PubMed  Google Scholar 

Wong D, Sogerer L, Lee SS, Wong V, Lum A, Levine AB, et al. TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L. BMC Biol. 2020;18:154.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takayama KI, Suzuki T, Tanaka T, Fujimura T, Takahashi S, Urano T, et al. TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer. Oncogene. 2018;37:2165–80.

Article  CAS  PubMed  Google Scholar 

Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007;446:916–20.

Article  CAS  PubMed  Google Scholar 

Yang Z, Wang J, He B, Zhang X, Li X, Kuang E. RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination. Elife. 2021;10:e68958.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao Z, Hua L, Ye Y, Wang D, Li C, Xie Q, et al. MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma. Neuro Oncol. 2021;23:2014–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Yu Y, Liu Y, Luo Z, Law BYK, Zheng Y, et al. Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer. Pharmacol Res. 2022;182:106306.

Article  CAS  PubMed  Google Scholar 

Moujalled D, Southon AG, Saleh E, Brinkmann K, Ke F, Iliopoulos M, et al. BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells. Cell Death Differ. 2022;29:1335–48.

Article  CAS  PubMed  Google Scholar 

Feng H, Liu Y, Gan Y, Li M, Liu R, Liang Z, et al. AdipoR1 regulates ionizing radiation-induced ferroptosis in HCC cells through Nrf2/xCT pathway. Oxid Med Cell Longev. 2022;2022:8091464.

Article  PubMed  PubMed Central  Google Scholar 

Ma L, Wei J, Wan J, Wang W, Wang L, Yuan Y, et al. Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways. J Exp Clin Cancer Res. 2019;38:77.

Article  PubMed  PubMed Central  Google Scholar 

Wan J, Liu H, Yang L, Ma L, Liu J, Ming L. JMJD6 promotes hepatocellular carcinoma carcinogenesis by targeting CDK4. Int J Cancer. 2019;144:2489–500.