Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, et al. World Stroke Organization (WSO): global stroke fact sheet 2022. Int J Stroke. 2022;17:18–29.

Article  PubMed  Google Scholar 

Naghavi M, Abajobir AA, Abbafati C, Abbas KM, Abd-Allah F, Abera SF, et al. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390:1151–210.

Article  Google Scholar 

Kumar KP, Wong CH. Imbalance in the force: the dark side of the microbiota on stroke risk and progression. Curr Opin Neurobiol. 2020;62:10–6.

Article  Google Scholar 

Shindler-Itskovitch T, Chodick G, Shalev V, Muhsen K. Helicobacter pylori infection and prevalence of stroke. Helicobacter. 2019;24: e12553.

Article  PubMed  Google Scholar 

Mezmale L, Coelho LG, Bordin D, Leja M. Review: epidemiology of Helicobacter pylori. Helicobacter. 2020;25(Suppl 1): e12734.

PubMed  Google Scholar 

Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017;153:420–9.

Article  PubMed  Google Scholar 

Yuan C, Adeloye D, Luk TT, Huang L, He Y, Xu Y, et al. The global prevalence of and factors associated with Helicobacter pylori infection in children: a systematic review and meta-analysis. Lancet Child Adolesc Health. 2022;6:185–94.

Article  PubMed  Google Scholar 

Butler-Laporte G, Kreuzer D, Nakanishi T, Harroud A, Forgetta V, Richards JB. Genetic determinants of antibody-mediated immune responses to infectious diseases agents: a genome-wide and HLA association study. In Open forum infectious diseases. 2020; Oxford University Press US. ofaa450.

Nejati S, Karkhah A, Darvish H, Validi M, Ebrahimpour S, Nouri HR. Influence of Helicobacter pylori virulence factors CagA and VacA on pathogenesis of gastrointestinal disorders. Microb Pathog. 2018;117:43–8.

Article  CAS  PubMed  Google Scholar 

Longo-Mbenza B, Nsenga JN, Mokondjimobe E, Gombet T, Assori IN, Ibara JR, et al. Helicobacter pylori infection is identified as a cardiovascular risk factor in Central Africans. Vascular Health Risk Manag. 2012;8:455.

Article  CAS  Google Scholar 

Yang X, Gao Y, Zhao X, Tang Y, Su Y. Chronic Helicobacter pylori infection and ischemic stroke subtypes. Neurol Res. 2011;33:467–72.

Article  PubMed  Google Scholar 

Yu M, Zhang Y, Yang Z, Ding J, Xie C, Lu N. Association between Helicobacter pylori infection and stroke: a meta-analysis of prospective observational studies. J Stroke Cerebrovasc Dis. 2014;23:2233–9.

Article  PubMed  Google Scholar 

Doheim MF, Altaweel AA, Elgendy MG, Elshanbary AA, Dibas M, Ali AAHA, et al. Association between Helicobacter pylori infection and stroke: a meta-analysis of 273,135 patients. J Neurol. 2021;268:3238–48.

Article  CAS  PubMed  Google Scholar 

Fewell Z, Davey Smith G, Sterne JA. The impact of residual and unmeasured confounding in epidemiologic studies: a simulation study. Am J Epidemiol. 2007;166:646–55.

Article  PubMed  Google Scholar 

Xu Z, Wang L, Lin Y, Wang Z, Zhang Y, Li J, et al. The impacts of peptic ulcer on stroke recurrence. J Stroke Cerebrovasc Dis. 2018;27:2106–11.

Article  PubMed  Google Scholar 

Kelly PJ, Lemmens R, Tsivgoulis G. Inflammation and stroke risk: a new target for prevention. Stroke. 2021;52:2697–706.

Article  PubMed  Google Scholar 

Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. Jama. 2017;318:1925–6.

Article  PubMed  Google Scholar 

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018;50:524–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, et al. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet. 2014;94:511–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ligthart S, Vaez A, Võsa U, Stathopoulou MG, De Vries PS, Prins BP, et al. Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders. Am J Hum Genet. 2018;103:691–706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, et al. Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. Nat Metab. 2020;2:1135–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo X, Tang P, Hou C, Liu Y, Li R. Impaired pulmonary function mediates the impact of preterm birth on later-life stroke: a 2-step, multivariable Mendelian randomization study. Epidemiol Health 2023; e2023031.

Kotilea K, Bontems P, Touati E. Epidemiology, diagnosis and risk factors of Helicobacter pylori infection. Adv Exp Med Biol. 2019;1149:17–33.

Article  CAS  PubMed  Google Scholar 

Boehme AK, Esenwa C, Elkind MS. Stroke risk factors, genetics, and prevention. Circ Res. 2017;120:472–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, et al. The MR-Base platform supports systematic causal inference across the human phenome. elife, 2018;7.

Guo X, Chong L, Zhang X, Li R. Immunosuppressants contribute to a reduced risk of Parkinson’s disease in rheumatoid arthritis. Int J Epidemiol. 2022;51:1328–38.

Article  PubMed  Google Scholar 

Verbanck M, Chen C-Y, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:693–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang M-H, Eyun S-i, Park Y-Y. Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer. Biochem Biophys Res Commun. 2021;563:15–22.

Article  CAS  PubMed  Google Scholar 

Wang B, Yu M, Zhang R, Chen S, Xi Y, Duan G. A meta-analysis of the association between Helicobacter pylori infection and risk of atherosclerotic cardiovascular disease. Helicobacter. 2020;25: e12761.

Article  CAS  PubMed  Google Scholar 

Xiang Z, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun. 1995;63:94–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palframan SL, Kwok T, Gabriel K. Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis. Front Cell Infect Microbiol. 2012;2:92.

Article  PubMed  PubMed Central  Google Scholar 

Link A, Langner C, Schirrmeister W, Habendorf W, Weigt J, Venerito M, et al. Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA. World J Gastroenterol. 2017;23:4712.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan KF, Formichella L, Zhang L, Zhang Y, Ma JL, Li ZX, et al. Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population. Int J Cancer. 2014;134:2118–25.

Article  CAS  PubMed  Google Scholar 

Bergonzelli GE, Granato D, Pridmore RD, Marvin-Guy LF, Donnicola D, Corthésy-Theulaz IE. GroEL of Lactobacillus johnsonii La1 (NCC 533) is cell surface associated: potential role in interactions with the host and the gastric pathogen Helicobacter pylori. Infect Immun. 2006;74:425–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamaguchi H, Osaki T, Kai M, Taguchi H, Kamiya S. Immune response against a cross-reactive epitope on the heat shock protein 60 homologue of Helicobacter pylori. Infect Immun. 2000;68:3448–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rustgi SD, Oh A, Hur C. Testing and treating Helicobacter pylori Infection in individuals with family history of gastric cancer is cost-effective. Gastroenterology. 2021;161(2051–2052): e2054.

Google Scholar 

Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, et al. Circulating monocyte chemoattractant protein-1 and risk of stroke: meta-analysis of population-based studies involving 17 180 individuals. Circ Res. 2019;125:773–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong S-I, Kim J-S, Bae HJ, Kim WY. C-reactive protein for stroke detection in the emergency department in patients with dizziness without neurological deficits. Front Neurol. 2021;12: 662510.

Article  PubMed  PubMed Central  Google Scholar 

Zhang XG, Xue J, Yang WH, Xu XS, Sun HX, Hu L, et al. Inflammatory markers as independent predictors for stroke outcomes. Brain Behav. 2021;11: e01922.

Article  PubMed  Google Scholar 

Di Napoli M, Papa F, Bocola V. C-reactive protein in ischemic stroke: an independent prognostic factor. Stroke. 2001;32:917–24.