Vizcaychipi MP, Watts HR, O’Dea KP, et al. The therapeutic potential of atorvastatin in a mouse model of postoperative cognitive decline. Ann Surg. 2014;259:1235–44.

Article  PubMed  Google Scholar 

Evered L, Silbert B, Knopman DS, et al. Recommendations for the nomenclature of cognitive change associated with anesthesia and surgery-2018. Br J Anaesth. 2018;121:1005–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu B, Huang D, Guo Y, et al. Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients. CNS Neurosci Ther. 2021. https://doi.org/10.1111/cns.13763.

Article  PubMed  PubMed Central  Google Scholar 

Hovens IB, Schoemaker RG, van der Zee EA, Absalom AR, Heineman E, van Leeuwen BL. Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning. Brain Behav Immun. 2014;38:202–10.

Article  CAS  PubMed  Google Scholar 

Mu RH, Tan YZ, Fu LL, et al. 1-Methylnicotinamide attenuates lipopolysaccharide-induced cognitive deficits by targeting neuroinflammation and neuronal apoptosis. Int Immunopharmacol. 2019;77: 105918.

Article  CAS  PubMed  Google Scholar 

Fakih D, Zhao Z, Nicolle P, et al. Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem. J Neuroinflammation. 2019;16:268.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rahimifard M, Maqbool F, Moeini-Nodeh S, et al. Targeting the TLR4 signaling pathway by polyphenols: a novel therapeutic strategy for neuroinflammation. Aging Res Rev. 2017;36:11–9.

Article  CAS  Google Scholar 

El-Sahar AE, Shiha NA, El Sayed NS, Ahmed LA. Alogliptin attenuates lipopolysaccharide-induced neuroinflammation in mice through modulation of TLR4/MYD88/NF-kappaB and miRNA-155/SOCS-1 signaling pathways. Int J Neuropsychopharmacol. 2021;24:158–69.

Article  CAS  PubMed  Google Scholar 

Qiu LL, Pan W, Luo D, et al. Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca(2+)/calpain might contribute to postoperative cognitive dysfunction in aging mice. J Neuroinflammation. 2020;17:23.

Article  PubMed  PubMed Central  Google Scholar 

Houwing DJ, Esquivel-Franco DC, Ramsteijn AS, et al. Perinatal fluoxetine treatment and dams’ early life stress history have opposite effects on aggressive behavior while having little impact on sexual behavior of male rat offspring. Psychopharmacology. 2020;237:2589–600.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park BK, Kim NS, Kim YR, et al. Antidepressant and anti-neuroinflammatory effects of bangpungtongsung-san. Front Pharmacol. 2020;11:958.

Article  PubMed  PubMed Central  Google Scholar 

Park J, Jang KM, Park KK. Apamin suppresses LPS-induced neuroinflammatory responses by regulating SK channels and TLR4-mediated signaling pathways. Int J Mol Sci. 2020;21:4319.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho KH, Kim DC, Yoon CS, et al. Anti-neuroinflammatory effects of citreohybridonol involving TLR4-MyD88-mediated inhibition of NF-small ka, CyrillicB and MAPK signaling pathways in lipopolysaccharide-stimulated BV2 cells. Neurochem Int. 2016;95:55–62.

Article  CAS  PubMed  Google Scholar 

Sierksma AS, de Nijs L, Hoogland G, et al. Fluoxetine treatment induces seizure behavior and premature death in APPswe/PS1dE9 mice. J Alzheimers Dis. 2016;51:677–82.

Article  CAS  PubMed  Google Scholar 

Boggio PS, Fregni F, Bermpohl F, et al. Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson’s disease and concurrent depression. Mov Disord. 2005;20:1178–84.

Article  PubMed  Google Scholar 

Zheng ZH, Tu JL, Li XH, et al. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behav Immun. 2021;91:505–18.

Article  CAS  PubMed  Google Scholar 

Wang L, Yang JW, Lin LT, et al. Acupuncture attenuates inflammation in microglia of vascular dementia rats by inhibiting miR-93-mediated TLR4/MyD88/NF-kappaB signaling pathway. Oxid Med Cell Longev. 2020;2020:8253904.

PubMed  PubMed Central  Google Scholar 

Qian B, Yang Y, Yao Y, Liao Y, Lin Y. Upregulation of vascular endothelial growth factor receptor-1 contributes to sevoflurane preconditioning-mediated cardioprotection. Drug Des Devel Ther. 2018;12:769–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Q, Sun YM, Huang H, et al. Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation. J Neuroinflammation. 2021;18:41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017;2: e91229.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Dong H, Li N, et al. Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis. J Neuroinflammation. 2016;13:127.

Article  PubMed  PubMed Central  Google Scholar 

Lin D, Zuo Z. Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats. Neuropharmacology. 2011;61:1354–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao JY, Xiong BR, Zhang W, et al. PGE2-EP3 signaling exacerbates hippocampus-dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity-related proteins in aged mice. CNS Neurosci Ther. 2018;24:917–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Netto MB, de Oliveira Junior AN, Goldim M, et al. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats. Brain Behav Immun. 2018;73:661–9.

Article  CAS  PubMed  Google Scholar 

Meng B, Li X, Lu B, et al. The investigation of hippocampus-dependent cognitive decline induced by anesthesia/surgery in mice through integrated behavioral Z-scoring. Front Behav Neurosci. 2019;13:282.

Article  CAS  PubMed  Google Scholar 

Hovens IB, Schoemaker RG, van der Zee EA, Heineman E, Nyakas C, van Leeuwen BL. Surgery-induced behavioral changes in aged rats. Exp Gerontol. 2013;48:1204–11.

Article  PubMed  Google Scholar 

Tian M, Yang M, Li Z, et al. Fluoxetine suppresses inflammatory reaction in microglia under OGD/R challenge via modulation of NF-κB signaling. 2019. Biosci Rep. https://doi.org/10.1042/BSR20181584.

Article  PubMed  PubMed Central  Google Scholar 

Rammes G, Starker LK, Haseneder R, et al. Isoflurane anesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression. Neuropharmacology. 2009;56:626–36.

Article  CAS  PubMed  Google Scholar 

Gu J, Su S, Guo J, Zhu Y, Zhao M, Duan J. Anti-inflammatory and anti-apoptotic effects of the combination of ligusticum chuanxiong and radix paeoniae against focal cerebral ischemia via TLR4/MyD88/MAPK/NF-κB signaling pathway in MCAO rats. J Pharm Pharmacol. 2018;70:268–77.

Article  CAS  PubMed  Google Scholar 

Pushpakom S, Iorio F, Eyers PA, et al. Drug repurposing: progress, challenges and recommendations. Nat Rev Drug Discov. 2019;18:41–58.

Article  CAS  PubMed  Google Scholar 

Orgeta V, Tabet N, Nilforooshan R, Howard R. Efficacy of antidepressants for depression in alzheimer’s disease: systematic review and meta-analysis. J Alzheimers Dis. 2017;58:725–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chollet F, Tardy J, Albucher JF, et al. Fluoxetine for motor recovery after acute ischemic stroke (FLAME): a randomized placebo-controlled trial. Lancet Neurol. 2011;10:123–30.

Article  CAS  PubMed  Google Scholar 

Wang Y, Neumann M, Hansen K, et al. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma. 2011;28:259–68.

Article  PubMed  PubMed Central  Google Scholar 

Liepert J. Update on pharmacotherapy for stroke and traumatic brain injury recovery during rehabilitation. Curr Opin Neurol. 2016;29:700–5.

Article  CAS  PubMed  Google Scholar 

Collaboration ET. Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomized, double-blind, placebo-controlled trial. Lancet Neurol. 2020;19:661–9.

Article  Google Scholar 

Lin D, Yu L, Chen J, et al. Fluoxetine for reducing postoperative cognitive dysfunction in elderly patients after total knee replacement: study protocol for a single-center, double-blind, randomized, parallel-group, superiority, placebo-controlled trial. BMJ Open. 2022;12: e057000.

Article