Efficient colonic drug delivery in domestic pigs employing a tablet formulation with dual control concept
Keywords
Colonic drug delivery
Physiologically based pharmacokinetic modeling
Pharmacokinetic deconvolution
Domestic pig
Telemetric capsule
Abbreviations4-ASA
4-aminosalicylic acid
5-ASA
5-aminosalicylic acid
Ac-5-ASA
N-Acetyl-5-aminosalicylic acid
API
active pharmaceutical ingredient
CCR
controlled colonic release
IBD
inflammatory bowel disease
PBPK
physiologically based pharmacokinetic modeling
PBS
phosphate buffered saline
SITT
small intestinal transit time
WGTT
whole gut transit time
Data availability
Data will be made available on request.
© 2023 The Authors. Published by Elsevier B.V.
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