lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2

AbbreviationAATs

antiangiogenic therapies

ASCT2

alanine-serine-cysteine transporter 2

B.R.

bevacizumab resistance

CRCLM

colorectal cancer liver metastasis

Co-IP

co-immunoprecipitation

EGFR

epidermal growth factor receptor

EMT

epithelial-mesenchymal transition

FISH

fluorescence in situ hybridization

LAMP1

lysosome-associated membrane protein 1

lncRNA

Long non-coding RNAs

MDSC

myeloid-derived suppressor cell

RHGP

replacement histopathological growth patterns

RIP

RNA immunoprecipitation

R.R.

regorafenib resistance

RT-qPCR

real time quantitative polymerase chain reaction

TAMs

tumor-associated macrophages

Keywords

Antiangiogenic therapy resistance

Vessel co-option

lncRNA

SYTL5-OT4

ASCT2

Autophagic degradation

© 2023 The Authors. Published by Elsevier Ltd.

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