Alrashood ST (2016) Carbamazepine. Profiles Drug Subst Excip Relat Methodol 41:133–321

Article  CAS  PubMed  Google Scholar 

Awara WM, El-Gohary M, El-Nabi SH, Fadel WA (1998) In vivo and in vitro evaluation of the mutagenic potential of carbamazepine: does melatonin have anti-mutagenic activity? Toxicology 125(1):45–52

Article  CAS  PubMed  Google Scholar 

Bennett GD, Amore BM, Finnell RH, Wlodarczyk B, Kalhorn TF, Skiles GL, Nelson SD, Slattery JT (1996) Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse. J Pharmacol Exp Ther 279(3):1237–1242

CAS  PubMed  Google Scholar 

Blom S (1962) Trigeminal neuralgia: its treatment with a new anticonvulsant drug (G-32883). Lancet 1(7234):839–840

Article  CAS  PubMed  Google Scholar 

Brodie MJ, Dichter MA (1997) Established antiepileptic drugs. Seizure 6(3):159–174

Article  CAS  PubMed  Google Scholar 

Bu HZ, Kang P, Deese AJ, Zhao P, Pool WF (2005) Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine. Drug Metab Dispos 33(12):1920–1924

CAS  PubMed  Google Scholar 

Celik A (2006) The assessment of genotoxicity of carbamazepine using cytokinesis-block (CB) micronucleus assay in cultured human blood lymphocytes. Drug Chem Toxicol 29(2):227–236

Article  CAS  PubMed  Google Scholar 

Chen Y, Zhu N, Luo Y, Hu K, Liu Y (2018) Featured structure-activity relationships for some tri- and tetrachlorobiphenyls in human CYP2E1-activated mutagenicity—impact of the extent of ortho-chlorination. Chemosphere 210:467–475

Article  CAS  PubMed  Google Scholar 

Chen Y, Wu Y, Xiao W, Jia H, Glatt H, Shi M, Liu Y (2020) Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells. Toxicology 429:152329

Article  CAS  PubMed  Google Scholar 

Chen Z, Xie J, Li Q, Hu K, Yang Z, Yu H, Liu Y (2021) Human CYP enzyme-activated clastogenicity of 2-ethylhexyl diphenyl phosphate (a flame retardant) in mammalian cells. Environ Pollut 285:117527

Article  CAS  PubMed  Google Scholar 

David R, Talbot E, Allen B, Wilson A, Arshad U, Doherty A (2018) The development of an in vitro Pig-a assay in L5178Y cells. Arch Toxicol 92(4):1609–1623

Article  CAS  PubMed  Google Scholar 

Dertinger SD, Avlasevich SL, Torous DK, Bemis JC, Hove TT, O’Connell O, Martus H, Elhajouji A (2020) Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay. Environ Mol Mutagen 61(5):500–507

Article  CAS  PubMed  Google Scholar 

Dorn SB, Bolt HM, Thevis M, Diel P, Degen GH (2008) Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone. Arch Toxicol 82(4):257–263

Article  CAS  PubMed  Google Scholar 

Eichelbaum M, Tomson T, Tybring G, Bertilsson L (1985) Carbamazepine metabolism in man. Induction and pharmacogenetic aspects. Clin Pharmacokinet 10(1):80–90

Article  CAS  PubMed  Google Scholar 

Fricke-Galindo I, A LL, Jung-Cook H, Lopez-Lopez M (2018) Carbamazepine adverse drug reactions. Expert Rev Clin Pharmacol 11(7):705–718

Article  CAS  PubMed  Google Scholar 

Glatt HR, Oesch F, Frigerio A, Garattini S (1975) Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity. Int J Cancer 16(5):787–797

Article  CAS  PubMed  Google Scholar 

Gonzalez FJ, Yu AM (2006) Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol 46:41–64

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Y, Ma M, Li N, Hou R, Huang C, Oda Y, Wang Z (2018) Chlorination, chloramination and ozonation of carbamazepine enhance cytotoxicity and genotoxicity: multi-endpoint evaluation and identification of its genotoxic transformation products. J Hazard Mater 342:679–688

Article  CAS  PubMed  Google Scholar 

Hu K, Cai L, Li Z, Glatt H, Shi M, Liu Y (2020a) Human CYP2E1-dependent mutagenicity of benzene and its hydroxylated metabolites in V79-derived cells: suppression and enhancement by ethanol pretreatment. Environ Mol Mutagen 61(6):622–634

Article  CAS  PubMed  Google Scholar 

Hu K, Yu H, Li Z, Jin G, Jia H, Song M, Liu Y (2020b) Human CYP2E1-activated mutagenicity of dioxin-like PCBs 105 and 118-experimental data consistent with molecular docking results. Toxicology 437:152438

Article  CAS  PubMed  Google Scholar 

Ishiyama M, Miyazono Y, Sasamoto K, Ohkura Y, Ueno K (1997) A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Talanta 44(7):1299–1305

Article  CAS  PubMed  Google Scholar 

Israel M, Beaudry P (1988) Carbamazepine in psychiatry: a review. Can J Psychiatry 33(7):577–584

Article  CAS  PubMed  Google Scholar 

Jentink J, Dolk H, Loane MA, Morris JK, Wellesley D, Garne E, De Jong-van den Berg L, Group EASW (2010) Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ 341:c6581

Article  PubMed  PubMed Central  Google Scholar 

Jiang H, Lai Y, Hu K, Chen D, Liu B, Liu Y (2015) Genotoxicity of 1-methylpyrene and 1-hydroxymethylpyrene in Chinese hamster V79-derived cells expressing both human CYP2E1 and SULT1A1. Environ Mol Mutagen 56(4):404–411

Article  CAS  PubMed  Google Scholar 

Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FJ, Levy RH (1994) Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem Pharmacol 47(11):1969–1979

Article  CAS  PubMed  Google Scholar 

Konigstein M, Larisch M, Obe G (1984) Mutagenicity of antiepileptic drugs. I. Carbamazepine and some of its metabolites. Mutat Res 139(2):83–86

Article  CAS  PubMed  Google Scholar 

Kruger CT, Hofmann M, Hartwig A (2015) The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells. Arch Toxicol 89(12):2429–2443

Article  PubMed  Google Scholar 

Liu Y, Glatt H (2008) Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutat Res 643(1–2):64–69

Article  CAS  PubMed  Google Scholar 

Liu Y, Glatt H (2010) Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis. Environ Mol Mutagen 51(1):23–30

CAS  PubMed  Google Scholar 

Liu Y, Hu K, Jia H, Jin G, Glatt H, Jiang H (2017) Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme. Arch Toxicol 91(7):2663–2676

Article  CAS  PubMed  Google Scholar 

Luch A, Coffing SL, Tang YM, Schneider A, Soballa V, Greim H, Jefcoate CR, Seidel A, Greenlee WF, Baird WM, Doehmer J (1998) Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a, l]pyrene. Chem Res Toxicol 11(6):686–695

Article  CAS  PubMed  Google Scholar 

Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT (2003) Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem 278(19):17277–17283

Article  CAS  PubMed  Google Scholar 

Mehnert K, Düring R, Vogel W, Speit G (1984) Differences in the induction of SCEs between human whole blood cultures and purified lymphocyte cultures and the effect of an S9 mix. Mutat Res 130(6):403–410

Article  CAS  PubMed  Google Scholar 

Patsalos PN, Spencer EP, Berry DJ (2018) Therapeutic drug monitoring of antiepileptic drugs in epilepsy: a 2018 update. Ther Drug Monit 40(5):526–548

Article  CAS  PubMed  Google Scholar 

Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS (2008) Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. Drug Metab Dispos 36(8):1637–1649

Article  CAS  PubMed  Google Scholar 

Prot JM, Aninat C, Griscom L, Razan F, Brochot C, Guillouzo CG, Legallais C, Corlu A, Leclerc E (2011) Improvement of HepG2/C3a cell functions in a microfluidic biochip. Biotechnol Bioeng 108(7):1704–1715

Article  CAS  PubMed  Google